Adverse pregnancy outcomes and coronary artery disease risk: A negative control Mendelian randomization study
Tormod Rogne,
Dipender Gill
Abstract:Background: Adverse pregnancy outcomes are predictive for future cardiovascular disease risk, but it is unclear whether they play a causal role. We conducted a Mendelian randomization study with males as a negative control population to estimate the associations between genetic liability to adverse pregnancy outcomes and risk of coronary artery disease. Methods: We extracted uncorrelated (R2<0.01) single-nucleotide polymorphisms strongly associated (p-value<5e-8) with miscarriage, gestational diabetes, h… Show more
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