1998
DOI: 10.1136/fn.79.2.f150
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Adverse neonatal effects of maternal labetalol treatment

Abstract: Two infants with features of severe adrenergic blockade, pericardial eVusions, and myocardial hypertrophy were born to mothers receiving long term treatment with oral labetalol for hypertension in pregnancy. Labetalol was implicated in the aetiology of these problems. Pericardial eVusion and myocardial hypertrophy have not been associated with labetalol toxicity in neonates.

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Cited by 27 publications
(2 citation statements)
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“…22 For example, labetalol treatment is associated with foetal growth restriction and neonatal bradycardia. 23 Angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists treatment lead to foetal loss in animals and cause neonatal anuric renal failure in human. 24 Searching for effective and safe reagent to treat PIH is still in urgent need.…”
Section: Discussionmentioning
confidence: 99%
“…22 For example, labetalol treatment is associated with foetal growth restriction and neonatal bradycardia. 23 Angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists treatment lead to foetal loss in animals and cause neonatal anuric renal failure in human. 24 Searching for effective and safe reagent to treat PIH is still in urgent need.…”
Section: Discussionmentioning
confidence: 99%
“…Este deprime la conducción por medio del nodo auriculoventricular y, por consiguiente, permanecen contraindicados en pacientes con bradicardia severa o bloqueo auriculoventriculares (AV). Los pacientes que usan labetalol previamente o a lo largo de una intervención quirúrgica que involucre anestésicos en general tienen que ser vigilados minuciosamente debido a que sus efectos inotrópicos negativos tienen la posibilidad de ser aditivos con los de los anestésicos (Park, 1984;Crooks et al, 1998;Varon & Marik, 2008).…”
Section: Precauciones Y Contraindicacionesunclassified