Adverse maternal outcomes in women with asthma versus women without asthma

MacMullen, Nancy J.; Shen, Jay J.; Tymkow, Catherine

doi:10.1016/j.apnr.2009.03.004

Cited by 15 publications

(8 citation statements)

References 10 publications

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“…Asthma control was not significantly associated with any of the outcomes, although the risk of PIH was increased by 18%, albeit not significantly, among women with uncontrolled asthma. Nevertheless, the risks of PIH, gestational diabetes and cesarean delivery were higher among asthmatic women than in non-asthmatic women, confirming the findings of several previous studies [2][3][4][5][6][7][9][10][11][12].…”

Section: Discussionsupporting

confidence: 90%

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Associations of maternal asthma severity and control with pregnancy complications

2014

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Section: Discussionsupporting

confidence: 90%

“…Asthma is the most common respiratory condition that complicates pregnancy [1] and was found to be associated with an increased risk of adverse maternal outcomes, including pregnancy-induced hypertension (PIH) [2][3][4][5][6][7][8][9][10], gestational diabetes [3][4][5]7,9], and cesarean delivery [2][3][4]6,7,11,12].…”

Section: Introductionmentioning

confidence: 99%

Associations of maternal asthma severity and control with pregnancy complications

2014

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“…The relationship between maternal asthma and obstetric and neonatal outcomes has been widely studied, but differences across race/ethnicity have not been examined [3, 5, 14, 31–39]. To the best of our knowledge, our study is the first to investigate the joint effects of maternal asthma by maternal race/ethnicity on the odds of obstetric and neonatal complications.…”

Section: Discussionmentioning

confidence: 99%

Does maternal asthma contribute to racial/ethnic disparities in obstetrical and neonatal complications?

Flores¹,

Robledo²,

Hwang³

et al. 2015

Annals of Epidemiology

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Purpose Examine whether maternal asthma contributes to racial/ethnic differences in obstetric and neonatal complications. Methods Data on White (n=110,603), Black (n=50,284) and Hispanic (n=38,831) singleton deliveries came from the Consortium on Safe Labor. Multi-level logistic regression models, with an interaction term for asthma and race/ethnicity, estimated within-group adjusted odds ratios (aOR) for gestational diabetes, gestational hypertension, preeclampsia, placental abruption, premature rupture of membranes, preterm delivery, maternal hemorrhage, NICU admissions, small for gestational age (SGA), apnea, respiratory distress syndrome, transient tachypnea of the newborn, anemia and hyperbilirubinemia after adjustment for clinical and demographic confounders. Non-asthmatics of the same racial/ethnic group were the reference group. Results Compared to non-asthmatics, White asthmatics had increased odds of preeclampsia (aOR 1.28; 95% CI: 1.15–1.43) and maternal hemorrhage (1.14; 1.04–1.23). White and Hispanic infants were more likely to have NICU admissions (1.19; 1.11–1.28; 1.16; 1.02–1.32, respectively) and be SGA (1.11; 1.02–1.20; 1.26; 1.10–1.44, respectively) and Hispanic infants were more likely to have apnea (1.32; 1.02–1.69). Conclusions Maternal asthma did not impact most obstetric and neonatal complication risks within racial/ethnic groups. Despite their increased risk for both asthma and many complications, our findings for Black women were null. Asthma did not contribute to racial/ethnic disparities in complications.

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“…Women with asthma were more likely to have pre-eclampsia (odds ratio [OR]: 1.5, 95% CI: 1.25–1.81), gestational diabetes (OR: 1.68; 95% CI: 1.47–1.92) and a caesarean section delivery (risk ratio: 1.22; 95% CI: 1.16–1.25), compared with women without asthma and controlled for age, ethnicity, income, insurance status and co-morbidities. However, the prevalence of asthma was very low in this cohort (1.4%), and obesity unusually low (0.6% in the control group without asthma), which may be due to the method of reporting data [1]. In another study of singleton pregnancies from 2002 to 2008 at 12 centers in the US, women with asthma were found to have an increased risk of pre-eclampsia (adjusted OR [aOR]: 1.14; 95% CI: 1.06–1.22), gestational diabetes (aOR: 1.34; 95% CI: 1.15–1.56), pulmonary embolism (aOR: 1.71; 95% CI: 1.05–2.79) and maternal intensive care admission (aOR: 1.34; 95% CI: 1.04–1.72).…”

Section: Maternal Pregnancy Complications Associated With Asthmamentioning

confidence: 99%

“…Several recent studies have particularly focused on adverse maternal outcomes. For example, in 2010, MacMullen et al reported outcomes from 7777 pregnant women with asthma from 33 states in the USA in retrospective data from 2001 [1]. Women with asthma were more likely to have pre-eclampsia (odds ratio [OR]: 1.5, 95% CI: 1.25–1.81), gestational diabetes (OR: 1.68; 95% CI: 1.47–1.92) and a caesarean section delivery (risk ratio: 1.22; 95% CI: 1.16–1.25), compared with women without asthma and controlled for age, ethnicity, income, insurance status and co-morbidities.…”

Section: Maternal Pregnancy Complications Associated With Asthmamentioning

confidence: 99%

Maternal Complications and the Management of Asthma in Pregnancy

Vanders

Murphy

2015

Womens Health (Lond Engl)

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Pregnancy is a unique state requiring alterations in maternal physiology to accommodate the growing fetus. Whilst the maternal immune system is normally well adept at performing this task, the presence of immune disorders, such as asthma, often lead to pregnancy-related complications affecting both mother and baby. Australia has a high prevalence of asthma; with approximately 12% of pregnant women reported to have current asthma. Poor control of asthma is of far greater risk than the use of asthma medications. Being able to identify complications associated with asthma during pregnancy is of great importance in providing appropriate asthma management and medical care to these pregnant women, which may have lifelong consequences for their offspring.

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Adverse maternal outcomes in women with asthma versus women without asthma

Cited by 15 publications

References 10 publications

Associations of maternal asthma severity and control with pregnancy complications

Associations of maternal asthma severity and control with pregnancy complications

Does maternal asthma contribute to racial/ethnic disparities in obstetrical and neonatal complications?

Maternal Complications and the Management of Asthma in Pregnancy

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