Adverse maternal and perinatal outcomes in pregnant women with sickle cell disease: systematic review and meta-analysis

Oteng‐Ntim, Eugene; Meeks, Daveena; Seed, Paul; Webster, Louise; Howard, Jo; Doyle, Pat; Chappell, Lucy C

doi:10.1182/blood-2014-11-607317

Cited by 187 publications

(256 citation statements)

References 43 publications

Supporting

Mentioning

223

Contrasting

Unclassified

Order By: Relevance

“…Adolescents and adults with SCD may experience a wide array of reproductive issues including delayed puberty, hypogonadism, infertility, and pregnancy complications [118][119][120][121]. In men with SCD, vaso-occlusion and recurrent testicular infarction may contribute to hypogonadism [122,123].…”

Section: Reproductive Health In Adults With Scdmentioning

confidence: 99%

“…Less is known about fertility and reproductive health in women with SCD, and few studies have addressed this prospectively [129,130] [121]. Another meta-analysis reported a benefit of prophylactic blood transfusions in reducing maternal mortality, preterm births, and neonatal deaths [131]; however, this needs to be evaluated prospectively in a randomized trial.…”

Section: Reproductive Health In Adults With Scdmentioning

confidence: 99%

See 1 more Smart Citation

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

2015

View full text Add to dashboard Cite

Over the past 40 years, public health measures such as universal newborn screening, penicillin prophylaxis, vaccinations, and hydroxyurea therapy have led to an impressive decline in sickle cell disease (SCD)-related childhood mortality and SCD-related morbidity in high-income countries. We remain cautiously optimistic that the next 40 years will be focused on meeting current challenges in SCD by addressing chronic complications of SCD to reduce mortality and improve quality of life in a growing population of adults with SCD in high-income countries, while simultaneously decreasing the disparity of medical care between high and low-income countries.

show abstract

Section: Reproductive Health In Adults With Scdmentioning

confidence: 99%

Section: Reproductive Health In Adults With Scdmentioning

confidence: 99%

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

2015

View full text Add to dashboard Cite

show abstract

“…Pregnancy in women with SCD is currently viewed more favorably 4 than it was during the 1970s, when its avoidance was recommended. 5 Nevertheless, maternal and fetal morbidity and mortality [6][7][8][9] are still encountered, and further examination of interventions capable of mitigating these adverse pregnancy outcomes is needed.…”

Section: Introductionmentioning

confidence: 99%

Prophylactic transfusion for pregnant women with sickle cell disease: a systematic review and meta-analysis

Malinowski

Shehata

D’Souza

et al. 2015

Blood

View full text Add to dashboard Cite

Key Points• Prophylactic transfusion in pregnant women with SCD may reduce maternal mortality, vaso-occlusive pain events, and pulmonary complications.• Prophylactic transfusion in pregnant women with SCD may similarly reduce perinatal mortality, neonatal death, and preterm birth.Pregnancy in women with sickle cell disease is associated with adverse maternal and neonatal outcomes. Studies assessing the effects of prophylactic red blood cell transfusions on these outcomes have drawn inconsistent conclusions. The objective of this systematic review was to assess the effect of prophylactic compared with on-demand red blood cell transfusions on maternal and neonatal outcomes in women with sickle cell disease. A systematic search of several medical literature databases was conducted. Twelve studies involving 1291 participants met inclusion criteria. , and preterm birth (9 studies, 1123 participants; OR, 0.59; 95% CI, 0.37-0.96). Event rates for most of the results were low. Prophylactic transfusions may positively impact several adverse maternal and neonatal outcomes in women with sickle cell disease; however, the evidence stems from a relatively small number of studies with methodologic limitations. A prospective, multicenter, randomized trial is needed to determine whether the potential benefits balance the risks of prophylactic transfusions. (Blood. 2015;126(21):2424-2435

show abstract

“…In a systematic review of maternal and perinatal outcomes of pregnant women with sickle cell disease it was concluded that the risks are higher for pregnant women with sickle cell anemia -HbSS, and in low-income countries they are more susceptible to morbidity and mortality, in which access antenatal care with specialized multidisciplinary team are not properly systemized and implemented [23].…”

Section: Discussionmentioning

confidence: 99%

Pregnancy complications and perinatal outcomes of women with hemoglobinopathies

Salazar¹,

Ivo²,

Freitas³

et al. 2016

Int Arch Med

View full text Add to dashboard Cite

Objective: To estimate the prevalence of gestational complications and perinatal outcomes in women with and without hemoglobinopathies.Method: This is a cross-sectional study with a quantitative approach, performed from 110 medical records of pregnant women who underwent prenatal, childbirth, postpartum and perinatal care in a gynecology and obstetrics service of the University Hospital at the Federal University of Mato Grosso do Sul, Brazil, between 2010 and2011. Results: Gestational complications in women with and without hemoglobinopathies in the variables: obstetric (preterm labor, preeclampsia, ruptured membranes for more than six hours (17.06 times; 12.19 times; 4.27 times respectively); clinical: urinary tract infection, heart failure, severe anemia (2.97 times; 12.6 times; 9.75 times, respectively), and perinatal: cesarean delivery, neonatal infection; the newborn in the neonatal intensive care unit; fetal death, stillbirth (1.57 times; 39.00 times; 12.19 times; 12.9 times; 9.75 times; respectively) were higher in the presence of hemoglobinopathies. Conclusion:The pregnancy outcomes of women with hemoglobinopathies, perinatal and their newborns showed a higher prevalence of complications than women without this change. Pregnancy Complications and Perinatal Outcomes of Women with Hemoglobinopathies ORIGINAL

show abstract

Adverse maternal and perinatal outcomes in pregnant women with sickle cell disease: systematic review and meta-analysis

Cited by 187 publications

References 43 publications

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

Prophylactic transfusion for pregnant women with sickle cell disease: a systematic review and meta-analysis

Pregnancy complications and perinatal outcomes of women with hemoglobinopathies

Contact Info

Product

Resources

About