Adverse events of endoscopic full-thickness resection: results from the German and Dutch nationwide colorectal FTRD registry

Zwager, Liselotte W.; Müeller, Jens-Dominik; Stritzke, Bettina; Montazeri, Nahid S.M.; Caca, Karel; Dekker, Evelien; Fockens, Paul; Schmidt, Arthur; Bastiaansen, Barbara A.

doi:10.1016/j.gie.2022.11.005

Cited by 23 publications

(2 citation statements)

References 27 publications

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“…Another limitation of the FTRD system is linked to the lesion size because the whole lesion must fit the resection device to allow a complete resection. As reported by Zwager et al, in a case series of 1892 patients who underwent eFTR, the procedure is safe with a low overall AE rate of 11.3% and no AE-related mortality, while the severe AE rate requiring surgery was 2.2% [61].…”

Section: Endoscopic Full-thickness Resection (Eftr)supporting

confidence: 54%

Early Rectal Cancer and Local Excision: A Narrative Review

Binda,

Secco,

Tuccillo

et al. 2024

JCM

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A rise in the incidence of early rectal cancer consequent to bowel-screening programs around the world and an increase in the incidence in young adults has led to a growing interest in organ-sparing treatment options. The rectum, being the most distal portion of the large intestine, is a fertile ground for local excision techniques performed with endoscopic or surgical techniques. Moreover, the advancement in endoscopic optical evaluation and the better definition of imaging techniques allow for a more precise local staging of early rectal cancer. Although the local treatment of early rectal cancer seems promising, in clinical practice, a significant number of patients who could benefit from local excision techniques undergo total mesorectal excision (TME) as the first approach. All relevant prospective clinical trials were identified through a computer-assisted search of the PubMed, EMBASE, and Medline databases until January 2024. This review is dedicated to endoscopic and surgical local excision in the treatment of early rectal cancer and highlights its possible role in current and future clinical practice, taking into account surgical completion techniques and chemoradiotherapy.

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Section: Endoscopic Full-thickness Resection (Eftr)supporting

confidence: 54%

Early Rectal Cancer and Local Excision: A Narrative Review

Binda,

Secco,

Tuccillo

et al. 2024

JCM

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“…The procedure is much more common in the West, available for training in many referral centers. Compared to ESD, there are also lower complication rates, approximately 10-12%, including 5% major adverse events [ 14 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Hybrid endoscopic approaches for complex colorectal polyps with a non-lifting sign: the Greek experience

Tribonias

2024

aog

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Background Hybrid approaches combining endoscopic full-thickness resection (EFTR) with conventional techniques (endoscopic mucosal resection [EMR], endoscopic submucosal dissection [ESD]) have enabled the resection of difficult fibrotic colorectal adenomas exhibiting a “non-lifting” sign, and polyps in difficult positions. We present our cohort treated with either EMR+EFTR or ESD+EFTR as salvage hybrid endoscopic approaches for complex colorectal polyps not amenable to conventional techniques. Methods Retrospective analysis included technical success, histological confirmation of margin-free resection, assessment of adverse events and follow up with histological assessment. All patients underwent follow-up endoscopy at least 6 and 12 months post-resection. Results Fourteen patients underwent hybrid EFTR procedures (11 EMR+EFTR and 3 ESD+EFTR). Technical success was achieved in all cases where the full-thickness resection device (FTRD) was advanced to the site of the resection (100%). In 2 cases, the FTRD system could not be passed through the sigmoid colon because of severe chronic diverticulitis, subsequent fibrosis and stiffness. The mean lesion size in the EMR+EFTR group (41.7 mm; range 20-50 mm) was larger than the ESD+EFTR group (31.7 mm; range 30-35 mm). Six patients (42.9%) were histologically diagnosed with T1 carcinoma. The mean duration of hospitalization was 1.4 days. Follow-up endoscopy was available in all patients and no recurrence was observed with histological confirmation during a mean follow-up period of 15.4 months. Conclusion Hybrid procedures appear to be safe and effective treatments for complex colorectal lesions not amenable to EMR, ESD or EFTR alone, because of the lesion size, positive non-lifting sign, and difficult positions.

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Prinzipien der endoskopischen Resektion: Diagnostische und kurative Resektion von Mukosaneoplasien

Oyama,

Yahagi

2023

Atlas Frühkarzinome Des Gastrointestinaltrakts

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Adverse events of endoscopic full-thickness resection: results from the German and Dutch nationwide colorectal FTRD registry

Cited by 23 publications

References 27 publications

Early Rectal Cancer and Local Excision: A Narrative Review

Early Rectal Cancer and Local Excision: A Narrative Review

Hybrid endoscopic approaches for complex colorectal polyps with a non-lifting sign: the Greek experience

Prinzipien der endoskopischen Resektion: Diagnostische und kurative Resektion von Mukosaneoplasien

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