Adverse Events in Platelet Apheresis Donors: A Multivariate Analysis in a Hospital‐Based Program

Abstract

Apheresis procedures have a 150-fold higher incidence of SAEs requiring hospitalization compared to whole blood donation. Identification of donors at risk for complications can facilitate modification of the apheresis procedure in order to reduce the likelihood of adverse events. Although our study did not demonstrate a cause-effect relationship between platelet donation and the development of acute coronary syndromes, underlying cardiovascular disease was detected in 2 donors during or after the apheresis who were otherwise asymptomatic.

Adverse Events During Apheresis Procedures: Audit at a Tertiary Hospital

“…Citrate related reactions associated with apheresis are common donor related mild adverse events which are transient and self-limiting [2]. This well-known phenomenon is the result of the chelation of ionised calcium by the citrate present in ACD [8].…”

“…the automated cell separators which facilitate in-line separation of cellular from plasma component and then, selective extraction of required component with the 'depleted blood' being returned back to the donors. Many authors have reported the apheresis as a safer procedure which is associated with less frequent adverse donor reactions as compared to whole blood donations [2,3]. A multi-centric study reported the frequency of adverse reactions observed in apheresis donations ranges from 0.32 to 6.81 % [4].…”

“…vasovagal reactions, hypovolemia, haematoma formation, etc. ), these are associated with few unique adverse events which are not associated with standard phlebotomies and/or whole blood donations [2,3]. These may be attributed to the usage of anticoagulant 'Acid-Citrate-Dextrose' (ACD) causing hypocalcemia and longer donation periods [4].…”

Arteriovenous fistula formation in a volunteer allogeneic peripheral blood progenitor cell donor

“…3,4 Apheresis is also associated with complications including hypotension, hypocalcemia and venipuncture complications. 5 In a retrospective review of 2386 apheresis donors, 0.53% experienced venipuncture-related complications including hematoma development, pain or swelling at the venipuncture site, venous infiltration or peripheral neuropathy. 5 An additional review reported venipuncture complications in 1.15% of apheresis donations.…”

“…5 In a retrospective review of 2386 apheresis donors, 0.53% experienced venipuncture-related complications including hematoma development, pain or swelling at the venipuncture site, venous infiltration or peripheral neuropathy. 5 An additional review reported venipuncture complications in 1.15% of apheresis donations. 6 We describe a volunteer donor who developed an arteriovenous fistula after peripheral blood progenitor cell donation.…”