Adverse events in children and adolescents treated with antipsychotic medications

Jerrell, Jeanette M.; McIntyre, Roger S.

doi:10.1002/hup.932

Cited by 68 publications

(61 citation statements)

References 14 publications

(24 reference statements)

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“…Research has shown an association of APP with increased adverse effects, including extrapyramidal effects, [11][12][13] hyperprolactinemia, [14][15][16] sexual dysfunction, 17 hypersalivation, 18 sedation, 14 cognitive impairment, 19 and diabetes. 20,21 Possible increased risk of sudden cardiac death 22 and mortality 23,24 has been suggested. Additional concerns include drugdrug interactions, problems in determining cause and effect of different treatments, complex drug regimens resulting in decreased compliance, and greater cost.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of and factors associated with antipsychotic polypharmacy in patients with serious mental illness: Findings from a cross-sectional study in an upper-middle-income country

Armstrong

Temmingh

2017

Rev. Bras. Psiquiatr.

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Objective: The aim of our study was to examine the prevalence of and factors associated with antipsychotic polypharmacy (APP) among patients with serious mental illness in the current South African health care context. Methods: We collected data on patient, illness, and treatment characteristics of patients discharged on one or more antipsychotic agents from January to June 2014. We analyzed the associations of APP with demographic and clinical variables using hierarchical multivariable logistic regression, and examined prescription patterns. Results: The prevalence of APP in our study population of 577 patients was 28.4%. Demographic and clinical characteristics significantly associated with APP included age 4 29, male sex, diagnosis of schizophrenia, comorbid intellectual disability, comorbid substance use, greater number of hospital admissions, and high-dose prescribing. First-generation antipsychotics and long-acting injectable preparations were prominent in APP combinations. Co-prescription of anticholinergic agents and sodium valproate demonstrated a significant association with APP.Conclusion: APP appears common in our population, despite lack of evidence for the practice and possible risk of harm. Our findings suggest a complex interplay among patient, illness, and treatment factors relevant to APP in our setting that could be targeted for intervention.

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Section: Introductionmentioning

confidence: 99%

Prevalence of and factors associated with antipsychotic polypharmacy in patients with serious mental illness: Findings from a cross-sectional study in an upper-middle-income country

Armstrong

Temmingh

2017

Rev. Bras. Psiquiatr.

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“…[6][7][8][9] The incidence of T1DM varies with geography, age, gender, family history, and race. Risk for developing T1DM in childhood seems to increase with distance from the equator.…”

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confidence: 99%

The Interface of Child Mental Health and Juvenile Diabetes Mellitus

Fritsch

Overton

Robbins

2015

Psychiatric Clinics of North America

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“…One factor that can mediate this influence may be time of exposure. Children and adolescents with lengthy exposure to antipsychotic pharmacotherapy were at higher risk of developing neurological, nervous, and/or sensory conditions than were those taking antipsychotic medications for 5 months or less (Jerrell & McIntyre, 2008). Nevertheless, in general, AAs are better tolerated and show improved medication compliance than do TAs (Chakos, Lieberman, Hoffman, Bradford, & Sheitman, 2001).…”

Section: Adverse Impacts Of Typical and Aasmentioning

confidence: 94%

Atypical and typical antipsychotics in the schools

Noggle

Dean

2009

Psychology in the Schools

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The use of antipsychotic medications within the school‐age population is rapidly increasing. Although typical antipsychotics may be used in rare cases, this influx is largely secondary to the availability of the atypical antipsychotics. Reduction of possible adverse effects and increased efficacy represent the primary basis for the atypical antipsychotics' popularity over traditional agents. Although these agents, as their name suggests, are most commonly used to alleviate positive, as well as some negative, symptoms of psychotic manifestations, empirical evidence has suggested their efficacy in the treatment of other presentations. These include bipolar disorder, Attention‐Deficit/Hyperactivity Disorder and other disruptive behavior disorders, pervasive developmental disorders, anorexia nervosa, and tic disorders. Discussion of antipsychotic agents and their use in these presentations is offered. Information on positive and negative outcomes, including school impact, is provided. © 2009 Wiley Periodicals, Inc.

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Adverse events in children and adolescents treated with antipsychotic medications

Abstract: Pediatric exposure to antipsychotic polypharmacotherapy confers a higher risk of developing adverse events than monotherapy, especially for females.

Cited by 68 publications

References 14 publications

Prevalence of and factors associated with antipsychotic polypharmacy in patients with serious mental illness: Findings from a cross-sectional study in an upper-middle-income country

Prevalence of and factors associated with antipsychotic polypharmacy in patients with serious mental illness: Findings from a cross-sectional study in an upper-middle-income country

The Interface of Child Mental Health and Juvenile Diabetes Mellitus

Atypical and typical antipsychotics in the schools

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