Adverse events following immunization during mass vaccination campaigns at first introduction of a meningococcal A conjugate vaccine in Burkina Faso, 2010

Ouandaogo, Claude-Roger; Yaméogo, Tènè Marceline; Diomandé, Fabien; Sawadogo, Charles; Ouédraogo, Boukary; Ouédraogo-Traoré, Rasmata; Pezzoli, Lorenzo; Djingarey, Mamoudou Harouna; Mbakuliyemo, Nehemie; Zuber, Patrick L. F.

doi:10.1016/j.vaccine.2011.12.112

Cited by 39 publications

(45 citation statements)

References 15 publications

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“…Similar observations have been described with other vaccines. [7][8][9][10] The other signs and symptoms reported in this study were found to be similar to those described elsewhere with other vaccines. [8][9][10] No case of AEFI associated with OPV in adult population and in the pediatric population could be found with the use of available computer-assisted medical literature search programs.…”

Section: Discussionsupporting

confidence: 81%

“…[7][8][9][10] The other signs and symptoms reported in this study were found to be similar to those described elsewhere with other vaccines. [8][9][10] No case of AEFI associated with OPV in adult population and in the pediatric population could be found with the use of available computer-assisted medical literature search programs. However, according to a WHO document entitled 'supplementary information on vaccine safety, background rates of adverse events following immunization', 11 common minor vaccine reaction associated with OPV are fever, irritability, malaise, and non-specific symptoms, such as diarrhea, headache, and/or muscle pain.…”

Section: Discussionsupporting

confidence: 81%

“…3 In Africa, AEFI are less documented and particularly those related to OPV. 4,5 Furthermore, OPV is most of the time administered to infants, which makes AEFI description less precise, and during routine immunization, poliomyelitis vaccine is administered with other vaccines, which makes difficult causality assessment.…”

Section: Introductionmentioning

confidence: 99%

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Adverse events following immunization with oral poliovirus in Kinshasa, Democratic Republic of Congo: preliminary results

Nzolo

Aloni

Ngamasata

et al. 2013

Pathogens and Global Health

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Aim:We investigated the nature and frequency of adverse events following immunization (AEFI) associated with oral polio vaccines (OPV) in the general population in Kinshasa, Democratic Republic of Congo (DR Congo). Methods: The DR Congo National Pharmacovigilance Centre organized active AEFI surveillance during mass immunization campaigns for the general population from March to June 2011. A patient individual case safety report was used as a questionnaire and addressed to pupils and students from high schools and universities who had any adverse events after OPV administration. We used the preferred term from the WHO Adverse Reaction Terminology for AEFI designation. Here is presented the results of the second step of the mass immunization campaign. Results: A total of 767 patients reported AEFI during the second step. Sex distribution shows that 512 (66.8%) students were females, while 255 (33.2%) were males, giving a female/male ratio 2 : 1. The average age was 16.865.19 years (ranged: 6-35.5 years). Each person reported a mean of 1.3360.6 AEFI. The average AEFI onset duration was 1.7461.16 days post-vaccination, ranging from 1 to 9 days. Headache (22.4%), abdominal pain (17.2%), fever (11.7%), diarrhea (9.9%), and asthenia (7.5%) were the common symptoms. Paralysis and asthma-like reactions were rare and serious adverse events in this study. The most affected systems were gastro-intestinal (33.5%) and nervous system (29.3%). Rechallenge was positive for 173 persons (22.6%). Conclusion: OPV-related AEFIs are not uncommon, although it is under-reported. Active AEFI surveillance during mass immunization campaigns is very important and may help to detect rare and serious adverse events. Further investigation will be important to identify risk of AEFI with OPV in adults and is warranted to elucidate the cause of this association in the Congolese environment.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 81%

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Adverse events following immunization with oral poliovirus in Kinshasa, Democratic Republic of Congo: preliminary results

Nzolo

Aloni

Ngamasata

et al. 2013

Pathogens and Global Health

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“…Hence, the target population was fully vaccinated before the next epidemic season. Monitoring of the adverse events related to MenAfriVac vaccination in Burkina Faso confirmed previous safety data [65]. [66].…”

Section: Mass Vaccination Campaignssupporting

confidence: 79%

Serogroup A meningococcal conjugate vaccines in Africa

Kristiansen

Jørgensen

Caugant

2015

Expert Review of Vaccines

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Serogroup A meningococcal epidemics have been a recurrent public health problem, especially in resource-poor countries of Africa. Recently, the administration in mass vaccination campaigns of a single dose of the monovalent meningococcal conjugate vaccine, MenAfriVac, to the 1-29 year-old population of sub-Saharan Africa has prevented epidemics of meningitis caused by serogroup A Neisseria meningitidis. This strategy has also been shown to provide herd protection of the non-vaccinated population. Development of meningococcal conjugate vaccines covering other serogroups and enhanced use of the pneumococcal and Haemophilus influenzae type b conjugate vaccines must be pursued to fully control bacterial meningitis in sub-Saharan Africa.

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“…The close association between the vaccinations and the onset of hearing loss suggests, however, that it may be the result of an adverse reaction to vaccines. A variety of adverse reactions to vaccines is certainly known: anesthesia, paraesthesia, chronic arthritis, encephalopathy, hypotonia/hypersensitivity, manifestations immediate hypersensitivity, meningitis, brachial neuritis, acute flaccid paralysis, persistent cry, thrombocytopenic purpura, anaphylactic shock, Guillan-Barrè/polyradicoloneurite, encephalitis and convulsions [6,7,8,9,10,11]. However, the data on possible neurological collateral effects following vaccination in the literature are few and inconsistent.…”

Section: Discussionmentioning

confidence: 99%

Post Vaccinal Temporary Sensorineural Hearing Loss

Marco

Cesare

Folco

et al. 2018

IJERPH

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In our systematic research we identified four studies concerning the onset of neurological adverse events following vaccination and two excluding this association. A 33-year-old Italian man, belonging to the Italian Army was hospitalized because he suffered from vertigo, nausea and sudden right hearing loss not classified (NDD), that set in 24 h after the administration of tetanus-diphtheria and meningococcal vaccines. Some neurological events arising after vaccination are very difficult to treat. In our case, the functional recovery on low and medium frequencies was possible about 6 months after the morbid event.

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Adverse events following immunization during mass vaccination campaigns at first introduction of a meningococcal A conjugate vaccine in Burkina Faso, 2010

Cited by 39 publications

References 15 publications

Adverse events following immunization with oral poliovirus in Kinshasa, Democratic Republic of Congo: preliminary results

Adverse events following immunization with oral poliovirus in Kinshasa, Democratic Republic of Congo: preliminary results

Serogroup A meningococcal conjugate vaccines in Africa

Post Vaccinal Temporary Sensorineural Hearing Loss

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