Adverse events following HPV vaccination, Alberta 2006–2014

Liu, Xianfang C.; Bell, Christopher; Simmonds, Kimberley; Svenson, Lawrence W.; Russell, Margaret L.

doi:10.1016/j.vaccine.2016.02.040

Cited by 27 publications

(18 citation statements)

References 12 publications

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“…Epidemiological studies conducted globally since the launch of the HPV vaccines have failed to find any increased risk of developing conditions claimed to be associated with the vaccine such as complex regional pain syndrome (CRPS) [10] , [11] , postural orthostatic tachycardia syndrome (POTS) [11] , multiple sclerosis or other demyelinating diseases [12] , venous thromboembolism [13] , or any other adverse events following immunization [14] . A meta-analysis [15] and a recent review [16] found that both the bi- and quadrivalent HPV vaccines were safe.…”

Section: Introductionmentioning

confidence: 99%

No association between HPV vaccine and reported post-vaccination symptoms in Japanese young women: Results of the Nagoya study

Suzuki

Hosono

2018

Papillomavirus Research

149

115

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Nagoya City introduced free HPV vaccination in 2010 and in April 2013 the Ministry of Health, Labour and Welfare included the HPV vaccine in the National Immunization Program. However, in June 2013, the Ministry suspended proactive recommendation of the vaccine after unconfirmed reports of adverse events. To investigate any potential association between the vaccine and reported symptoms, Nagoya City conducted a questionnaire-based survey.Participants were 71,177 female residents of Nagoya City born between April 2, 1994 and April 1, 2001. The anonymous postal questionnaire investigated the onset of 24 symptoms (primary outcome), associated hospital visits, frequency, and influence on school attendance.Totally, 29,846 residents responded. No significant increase in occurrence of any of the 24 reported post-HPV vaccination symptoms was found. The vaccine was associated with increased age-adjusted odds of hospital visits for “abnormal amount of menstrual bleeding” (OR: 1.43, 95% CI: 1.13–1.82), “irregular menstruation” (OR: 1.29, 95% CI: 1.12–1.49), “severe headaches” (OR: 1.19, 95% CI: 1.02–1.39), and chronic, persisting “abnormal amount of menstrual bleeding” (OR 1.41, 95% CI: 1.11–1.79). No symptoms significantly influenced school attendance and no accumulation of symptoms was observed.The results suggest no causal association between the HPV vaccines and reported symptoms.

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Section: Introductionmentioning

confidence: 99%

No association between HPV vaccine and reported post-vaccination symptoms in Japanese young women: Results of the Nagoya study

Suzuki

Hosono

2018

Papillomavirus Research

149

115

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“…Several possibilities can be offered to address this problem. For instance, reminder/recall systems can help to identify the cross-border child, the system could allow their citizens to update their own information 108 or an IIS interconnected with civil registries could reduce this bias. 157 Timeliness is another aspect that should be taken into account.…”

Section: Discussionmentioning

confidence: 99%

“…94 Another example of IIS connected to AEFI surveillance system is the Alberta IIS, where AEFIs related to HPV vaccination were explored. 108 Among 195,270 women who received the vaccine, only 192 reported AEFIs. They were also able to know the type of AEFI reported, how many days after the immunization, associated dose, if hospitalization was required and the outcome.…”

Section: Possibility To Record Aefimentioning

confidence: 99%

Countering vaccine hesitancy through immunization information systems, a narrative review

Gianfredi

Moretti

Lopalco

2019

Human Vaccines & Immunotherapeutics

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Immunization is one of the most important public health interventions to contrast infectious disease; however, many people nowadays refuse vaccination. Vaccine hesitancy (VH) is due to several factors that influence the complex decision-making process. Information technology tools might play an important role in vaccination programs. In particular, immunization information systems (IISs) have the potential to improve performance of vaccination programs and to increase vaccine uptake. This review aimed to present IIS functionalities in order to counter VH. In detail, we analyzed the automatic reminder/recall system, the interoperability of the system, the decision support system, the web page interface and the possibility to record adverse events following immunization. IIS could concretely represent a valid instrument to increase vaccine confidence, especially trust in both health-care workers and decision makers. There are not enough trials aimed to evaluate the efficacy of IIS to counter VH. Further researches might focalize on this aspect.

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“…The prevalence of HPV infection and cervical cancer is significantly higher [ 11 – 23 ] and HPV vaccination rates lower among Indigenous peoples [ 23 ]. This inequity exists despite the availability of vaccines with demonstrated safety profiles and efficacy, and funded vaccination programs [ 24 – 26 ].…”

Section: Introductionmentioning

confidence: 99%

“…Vaccines preventing HPV infection demonstrate long-term effectiveness and acceptable safety profiles [ 24 ]. However, a number of issues specific to the HPV vaccine influence its acceptability and uptake in the general population; these factors are well described in systematic reviews [ 25 , 26 , 57 – 61 ] and include knowledge and perceived risk of HPV disease, misinformation about vaccine safety, cost, misperceptions that the vaccine induces sexual promiscuity, and multi-dose vaccine series delivery. Additional challenges in the school setting include the information and consent process, vaccination setting, and student anxiety regarding privacy and pain during vaccination [ 62 ].…”

Section: Introductionmentioning

confidence: 99%

Barriers, supports, and effective interventions for uptake of human papillomavirus- and other vaccines within global and Canadian Indigenous peoples: a systematic review protocol

et al. 2018

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BackgroundDespite the existence of human papilloma virus (HPV) vaccines with demonstrated safety and effectiveness and funded HPV vaccination programs, coverage rates are persistently lower and cervical cancer burden higher among Canadian Indigenous peoples. Barriers and supports to HPV vaccination in Indigenous peoples have not been systematically documented, nor have interventions to increase uptake in this population. This protocol aims to appraise the literature in Canadian and global Indigenous peoples, relating to documented barriers and supports to vaccination and interventions to increase acceptability/uptake or reduce hesitancy of vaccination. Although HPV vaccination is the primary focus, we anticipate only a small number of relevant studies to emerge from the search and will, therefore, employ a broad search strategy to capture literature related to both HPV vaccination and vaccination in general in global Indigenous peoples.MethodsEligible studies will include global Indigenous peoples and discuss barriers or supports and/or interventions to improve uptake or to reduce hesitancy, for the HPV vaccine and/or other vaccines. Primary outcomes are documented barriers or supports or interventions. All study designs meeting inclusion criteria will be considered, without restricting by language, location, or data type. We will use an a priori search strategy, comprised of key words and controlled vocabulary terms, developed in consultation with an academic librarian, and reviewed by a second academic librarian using the PRESS checklist. We will search several electronic databases from date of inception, without restrictions. A pre-defined group of global Indigenous websites will be reviewed for relevant gray literature. Bibliographic searches will be conducted for all included studies to identify relevant reviews. Data analysis will include an inductive, qualitative, thematic synthesis and a quantitative analysis of measured barriers and supports, as well as a descriptive synthesis and quantitative summary of measures for interventions.DiscussionTo our knowledge, this study will contribute the first systematic review of documented barriers, supports, and interventions for vaccination in general and for HPV vaccination. The results of this study are expected to inform future research, policies, programs, and community-driven initiatives to enhance acceptability and uptake of HPV vaccination among Indigenous peoples.Systematic review registrationPROSPERO Registration Number: CRD42017048844Electronic supplementary materialThe online version of this article (10.1186/s13643-018-0692-y) contains supplementary material, which is available to authorized users.

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Adverse events following HPV vaccination, Alberta 2006–2014

Abstract: Rates of AEFI after HPV immunization in Alberta are low and consistent with types of events seen elsewhere.

Cited by 27 publications

References 12 publications

No association between HPV vaccine and reported post-vaccination symptoms in Japanese young women: Results of the Nagoya study

No association between HPV vaccine and reported post-vaccination symptoms in Japanese young women: Results of the Nagoya study

Countering vaccine hesitancy through immunization information systems, a narrative review

Barriers, supports, and effective interventions for uptake of human papillomavirus- and other vaccines within global and Canadian Indigenous peoples: a systematic review protocol

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