Adverse events following COVID-19 vaccination among pregnant women attending primary health centers: An active-surveillance study

Goruntla, Narayana; Karisetty, Basappa; Nandini, Nandini; Bhupasamudram, Bharadwaj; Gangireddy, Himaja Reddy; Veerabhadrappa, Kasturi Vishwanathasetty; Ezeonwumelu, Joseph Obiezu Chukwujekwu; Bandaru, Vishnuvandana

doi:10.1016/j.vacun.2023.05.003

Cited by 3 publications

(1 citation statement)

References 25 publications

(25 reference statements)

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“… 70 Studies from India however report a higher uptake (64.4%-66.8%). 71 , 72 Even before the vaccine approval, a multi-national survey conducted in sixteen countries demonstrated that assuming 90% COVID-19 vaccine efficacy the willingness for COVID-19 vaccine was highest among pregnant women from India (>80%) and Mexico, but lower in high-income nations like the USA, Russia, and Australia (45%). 73 Other studies revealed an intention of 37% in Turkey, 74 44.3% in the USA, 75 60.4% in Vietnam, 76 93.7% in Saudi Arabia 77 and 78.5% from India.…”

Section: Discussionmentioning

confidence: 99%

Factors influencing vaccine acceptance in pregnancy during the COVID-19 pandemic: A multicenter study from West Bengal, India

Khan,

Das,

Jana

et al. 2024

Human Vaccines & Immunotherapeutics

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Influenza, COVID-19, tetanus, pertussis and hepatitis B pose increased risk for pregnant women and infants and could be mitigated by maternal immunization. In India Tetanus-diphtheria (Td) and COVID-19 vaccines are recommended during pregnancy, while influenza and tetanus-acellular pertussis-diphtheria (Tdap) vaccines are not. We conducted a multicenter study from November 2021 to June 2022 among pregnant women ( n = 172) attending antenatal clinics in three public hospitals in West Bengal, to understand the factors that influence women’s decisions to get vaccinated during pregnancy. Questions assessed vaccination coverage, knowledge, intention and willingness to pay for influenza vaccine, and factors influencing decisions to get Td, influenza, and COVID-19 vaccines. 152/172 (88.4%) women were vaccinated with Td, 159/172 (93%) with COVID-19, 1/172 (0.6%) with influenza, and none with Tdap. 10/168 (6%) had received hepatitis B vaccine (HBV). Community health workers advice was crucial for Td uptake and, the belief of protection from COVID for COVID-19 vaccines. Most women were unaware about Tdap (96%), influenza (75%), and influenza severity during pregnancy and infancy (85%). None were advised for influenza vaccination by healthcare providers (HCP), albeit, 93% expressed willingness to take, and pay INR 100–300 (95% CI: ≤100 to 300–500) [$ 1.3–4.0 (95% CI: ≤1.3, 4–6.7)] for it. Vaccination on flexible dates and time, HCP’s recommendation, proximity to vaccination center, and husband’s support were most important for their vaccination decisions. Women were generally vaccine acceptors and had high uptake of vaccines included in the Universal Immunization Program (UIP). Inclusion of influenza, Tdap, and HBV into UIP may improve maternal vaccine uptake.

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Section: Discussionmentioning

confidence: 99%

Factors influencing vaccine acceptance in pregnancy during the COVID-19 pandemic: A multicenter study from West Bengal, India

Khan,

Das,

Jana

et al. 2024

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

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Establishing vaccine pregnancy registries and active surveillance studies in low-and middle-income countries: Experience from an observational cohort surveillance project in The Gambia

Kochhar,

Okomo,

Nkereuwem

et al. 2023

Vaccine

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Safety of COVID-19 Vaccination in Pregnancy: A Systematic Review

Gerede,

Daskalakis,

Mikos

et al. 2024

Diagnostics

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The COVID-19 pandemic has posed significant risks to pregnant women and those recently pregnant, leading to heightened mortality and morbidity rates. Vaccination has emerged as a pivotal strategy in reducing COVID-19-related deaths and illnesses worldwide. However, the initial exclusion of pregnant individuals from most clinical trials raised concerns about vaccine safety in this population, contributing to vaccine hesitancy. This review aims to consolidate the existing literature to assess the safety and efficacy of COVID-19 vaccination in pregnant populations and neonatal outcomes. Diverse studies were included evaluating various aspects of safety for women and their newborns, encompassing mild to severe symptoms across different vaccines. The findings indicate the overall safety and efficacy of COVID-19 vaccination, with minimal adverse outcomes observed, including mild side effects like pain and fever. Although most studies reported the absence of severe adverse outcomes, isolated case reports have raised concerns about potential associations between maternal COVID-19 vaccination and conditions such as fetal supraventricular tachycardia and immune-mediated diseases. Our review underscores the importance of ongoing surveillance and monitoring to ensure vaccine safety in pregnant women. Overall, COVID-19 vaccination during pregnancy remains a safe and effective strategy, emphasizing the need for continued research and vigilance to safeguard maternal and fetal health.

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Adverse events following COVID-19 vaccination among pregnant women attending primary health centers: An active-surveillance study

Cited by 3 publications

References 25 publications

Factors influencing vaccine acceptance in pregnancy during the COVID-19 pandemic: A multicenter study from West Bengal, India

Factors influencing vaccine acceptance in pregnancy during the COVID-19 pandemic: A multicenter study from West Bengal, India

Establishing vaccine pregnancy registries and active surveillance studies in low-and middle-income countries: Experience from an observational cohort surveillance project in The Gambia

Safety of COVID-19 Vaccination in Pregnancy: A Systematic Review

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