Adverse events associated with repeated sessions of tDCS: A systematic review and meta-analysis

Nikolin, Stevan; Huggins, Christina; Martin, Donel; Alonzo, Angelo; Loo, Colleen

doi:10.1016/j.brs.2018.12.577

Cited by 3 publications

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“…The number of clinical trials investigating the efficacy of transcranial direct current stimulation (tDCS) is rapidly increasing [ 7 ] due to its non-invasive nature, few side effects [ 8 ], and low economic burden [ 9 ]. This exploratory treatment has been tested widely for the treatment of major depressive disorder (MDD) [ 10 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Is transcranial direct current stimulation, alone or in combination with antidepressant medications or psychotherapies, effective in treating major depressive disorder? A systematic review and meta-analysis

Wang

Luo

Schülke

et al. 2021

BMC Med

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Background Transcranial direct current stimulation (tDCS) has shown mixed results for depression treatment. The efficacies of tDCS combination therapies have not been investigated deliberately. This review aims to evaluate the clinical efficacy of tDCS as a monotherapy and in combination with medication, psychotherapy, and ECT for treating adult patients with major depressive disorder (MDD) and identified the factors influencing treatment outcome measures (i.e. depression score, dropout, response, and remission rates). Methods The systematic review was performed in PubMed/Medline, EMBASE, PsycINFO, Web of Sciences, and OpenGrey. Two authors performed independent literature screening and data extraction. The primary outcomes were the standardized mean difference (SMD) for continuous depression scores after treatment and odds ratio (OR) dropout rate; secondary outcomes included ORs for response and remission rates. Random effects models with 95% confidence intervals were employed in all outcomes. The overall effect of tDCS was investigated by meta-analysis. Sources of heterogeneity were explored via subgroup analyses, meta-regression, sensitivity analyses, and assessment of publication bias. Results Twelve randomised, sham-controlled trials (active group: N = 251, sham group: N = 204) were included. Overall, the integrated depression score of the active group after treatment was significantly lower than that of the sham group (g = − 0.442, p = 0.017), and further analysis showed that only tDCS + medication achieved a significant lower score (g = − 0.855, p < 0.001). Moreover, this combination achieved a significantly higher response rate than sham intervention (OR = 2.7, p = 0.006), while the response rate remained unchanged for the other three therapies. Dropout and remission rates were similar in the active and sham groups for each therapy and also for the overall intervention. The meta-regression results showed that current intensity is the only predictor for the response rate. None of publication bias was identified. Conclusion The effect size of tDCS treatment was obviously larger in depression score compared with sham stimulation. The tDCS combined selective serotonin re-uptake inhibitors is the optimized therapy that is effective on depression score and response rate. tDCS monotherapy and combined psychotherapy have no significant effects. The most important parameter for optimization in future trials is treatment strategy.

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Section: Introductionmentioning

confidence: 99%

Is transcranial direct current stimulation, alone or in combination with antidepressant medications or psychotherapies, effective in treating major depressive disorder? A systematic review and meta-analysis

Wang

Luo

Schülke

et al. 2021

BMC Med

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“…In addition, there are lingering concerns about the safety of transcranial electrical stimulation. A large number of studies have shown that even repeated stimulation is safe and reliable compared with sham stimulation as long as the operational requirements of electrical stimulation were conducted in strict accordance with safety protocols ( Turski et al, 2017 ; Nikolin et al, 2019 ). Choe et al (2016) conducted electrical stimulation in the laboratory on 32 healthy subjects undergoing flight training to explore its influence on flight performance and the relevant data of EEG and fNIRS.…”

Section: Research Prospects For Transcranial Electrical Stimulation T...mentioning

confidence: 99%

Transcranial Electrical Stimulation Offers the Possibility of Improving Teamwork Among Military Pilots: A Review

et al. 2022

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Effective teamwork among military pilots is key to successful mission completion. The underlying neural mechanism of teamwork is thought to be inter-brain synchronization (IBS). IBS could also be explained as an incidental phenomenon of cooperative behavior, but the causality between IBS and cooperative behavior could be clarified by directly producing IBS through extra external stimuli applied to functional brain regions. As a non-invasive technology for altering brain function, transcranial electrical stimulation might have the potential to explore whether top-down enhancement of the synchronization of multiple brains can change cooperative behavioral performance among members of a team. This review focuses on the characteristic features of teamwork among military pilots and variations in neuroimaging obtained by hyper-scanning. Furthermore, we discuss the possibility that transcranial electrical stimulation could be used to improve teamwork among military pilots, try to provide a feasible design for doing so, and emphasize crucial aspects to be addressed by future research.

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tDCS in Child and Adolescent Psychiatry

Salehinejad

Vicario

Vila-Rodriguez

et al. 2021

Transcranial Direct Current Stimulation in Neuropsychiatric Disorders

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Adverse events associated with repeated sessions of tDCS: A systematic review and meta-analysis

Cited by 3 publications

References 0 publications

Is transcranial direct current stimulation, alone or in combination with antidepressant medications or psychotherapies, effective in treating major depressive disorder? A systematic review and meta-analysis

Is transcranial direct current stimulation, alone or in combination with antidepressant medications or psychotherapies, effective in treating major depressive disorder? A systematic review and meta-analysis

Transcranial Electrical Stimulation Offers the Possibility of Improving Teamwork Among Military Pilots: A Review

tDCS in Child and Adolescent Psychiatry

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