Adverse events and labeling issues related to suspected sesame allergy reported in an online survey

Nguyen, Kim Cuc Thi; Greenthal, Eva; Sorscher, Sarah; Lurie, Peter; Spergel, Jonathan M.; Kennedy, Kathleen E.

doi:10.1016/j.anai.2021.12.005

Cited by 8 publications

(9 citation statements)

References 18 publications

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“…In the United States, suspected sesame allergy was investigated using an online survey, in which 360 clinical reactions were reported in 327 individuals 28 . As in the previous study, the reactions were most likely to occur in children ages 1–5 years old (41%) or <1 year old (9.2%), with males more often affected than females (45.6% vs. 36.1%).…”

Section: The Prevalence and Natural History Of Sesame Allergymentioning

confidence: 92%

“…), and vitamins. Both proteins and lipid oleosins can trigger allergic reactions 28 . The World Health Organization (WHO)/International Union of Immunological Societies (IUIS) lists seven sesame allergen components, 30 as described in Table 1.…”

Section: Sesame Allergens Cross‐reactivity and Cosensitizationsmentioning

confidence: 99%

“…Both proteins and lipid oleosins can trigger allergic reactions. 28 The World Health Organization (WHO)/ International Union of Immunological Societies (IUIS) lists seven sesame allergen components, 30 as described in Table 1. The storage proteins Ses i 1 and Ses i 2 are stable to heat and digestive enzymes, which increase the risk of severe reactions and anaphylaxis.…”

Section: S E Same Allerg En S Cross -Re Ac Tivit Y and Cos En S It I...mentioning

confidence: 99%

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Sesame allergy in children: New insights into diagnosis and management

Saf,

Borres,

Södergren

2023

Pediatric Allergy Immunology

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Sesame is a potentially potent allergen that can trigger skin, gastrointestinal, and respiratory tract symptoms, and anaphylaxis. Only 20% to 30% of sesame‐allergic children develop tolerance. The prevalence of sesame allergy depends on local diets and ranges from 0.1% to 0.9%. A high risk of accidental exposure to sesame has resulted in mandatory food labeling in many countries. More than half of patients with sesame allergy are also allergic to peanut/tree nuts. Serum‐specific IgE testing with a quantitative Ses i 1 component can be performed safely and has higher clinical specificity and better positive predictive value for oral food challenge (OFC) than whole sesame extract or skin prick testing (SPT). Compared with SPT or OFC, in vitro Ses i 1 testing requires no special techniques and carries no risk of reactions. Diagnosis of suspected sesame allergy begins with a thorough history and physical examination. A positive sesame extract test (≥0.1 kUA/L) should prompt further testing. In patients with a high probability of reacting, results of component testing may facilitate a decision about performing an OFC. In a Japanese study of OFC and Ses i 1, there was a 5% probability of a positive OFC with Ses i 1 sIgE levels <0.13 kUA/L, and a 50% probability of a positive OFC with levels >32.0 kUA/L. Most patients could safely consume sesame if sIgE levels were <0.13 kUA/L. Ses i 1 testing can be used to guide appropriate management (avoidance, emergency medication, and oral immunotherapy).

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Section: The Prevalence and Natural History Of Sesame Allergymentioning

confidence: 92%

Section: Sesame Allergens Cross‐reactivity and Cosensitizationsmentioning

confidence: 99%

Section: S E Same Allerg En S Cross -Re Ac Tivit Y and Cos En S It I...mentioning

confidence: 99%

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Sesame allergy in children: New insights into diagnosis and management

Saf,

Borres,

Södergren

2023

Pediatric Allergy Immunology

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“…Labeling of sesame presence in food products is mandatory in the European Union. Although food labeling regulations in the United States currently do not recognize sesame as a priority allergen to be routinely included in food labels, there are efforts to change this 154,155 …”

Section: Methodsmentioning

confidence: 99%

“…Although food labeling regulations in the United States currently do not recognize sesame as a priority allergen to be routinely included in food labels, there are efforts to change this. 154,155 There is some evidence from preclinical experiments that sesame constituents may have the potential to interact with drugs by affecting the activity of several CYP enzymes involved in their metabolism. Specifically, sesamin is an inhibitor of CYP2C9, which is a CYP isoform that metabolizes anticlotting, diabetic, and nonsteroidal anti-inflammatory drugs.…”

Section: Safetymentioning

confidence: 99%

Sesame

Singletary¹

2022

Nutr Today

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Sesame (Sesamum indicum L.) is an annual plant whose seeds are purported to be one of the oldest oilseeds used by humans. Although originating in Africa and India, this plant currently is cultivated in diverse regions worldwide from semiarid tropics to temperate areas. This edible seed oil has many routine and diverse uses in food preparation and cooking, and the dehulled seed is included in the preparation of numerous food products, condiments, and confectionaries, imparting a distinctive savory, nutty, roasted flavor. Sesame has a long history of use in traditional medicines for treatment of wounds, asthma, blurred vision, abdominal pain and ulcers, toothaches and gum disease, and migraine, to name a few. More recently, sesame constituents have demonstrated antioxidant and anti-inflammatory properties that may alleviate conditions such as atherosclerosis, diabetes, hypertension, and pain. The current narrative summarizes human studies evaluating sesame seeds, oil, and constituents for improving diverse human disorders, and provides suggestions for future research. Nutr Today 2022;57(5):271-287 S esame (Sesamum indicum L., family Pedaliaceae), also known as sesamum, gingelly, til, goma, ajonjoli, and benniseed, is an annual plant (Figure 1). The seeds are purported to be one of the oldest oilseeds used by humans. The seed colors of this plant vary considerably including white, yellow, gray, brown, and black, depending on the variety and strain of S indicum. Black sesame seeds and white sesame seeds are the most available worldwide.Although the chemical differences among the various colored sesame seeds are not well characterized, it has been reported that the contents of indole-3-carboxylic acid, hesperidin, 2-methoxycinnamic acid, vitamin B2, and hyoscyamine are significantly higher in black seeds compared with white seeds. However, at least for sesame lignans, seed color and content of these bioactives are unrelated. 1,2 Although apparently originating in Africa and India, this plant is currently cultivated in diverse regions worldwide from semiarid tropics to temperate areas, and India, China, Tanzania, Sudan, and Myanmar are considered the major producers. Because of the high content of oil, sesame seed is called the queen of oilseeds. Its major use is the production of a notably oxidative rancidity-resistant oil. This oil has numerous uses such as a solvent, a hydrophobic vehicle for drug delivery, and a skin softener, and in the preparation of soaps and margarines. [2][3][4][5][6][7] In cosmetics, it can function as a binder, emulsifier, and viscosity-increasing agent. 8 As an edible seed oil, it has many routine and diverse uses in food preparation. It has widespread use globally in salads, and in Asia, the seed and oil are routinely used in cooking. Some Europeans substitute it for olive oil in cooking. The dehulled seed is included in the preparation of numerous food products, condiments, and confectionaries, imparting a distinctive savory, nutty, roasted flavor. For example, besides being sprinkled on ...

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