Adverse Effects of Nutraceuticals and Dietary Supplements

Ronis, Martin J. J.; Pedersen, Kim Brint; Watt, James

doi:10.1146/annurev-pharmtox-010617-052844

Cited by 238 publications

(171 citation statements)

References 130 publications

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“…Protein is an essential nutrient for cell growth and maintenance and supplementation has been shown to be of benefit if protein intake is inadequate [46,47]. However, much like other essential nutrients (such as vitamins or minerals), intakes over and above physiological requirements do not necessarily confer greater health benefits.…”

Section: Discussionmentioning

confidence: 99%

Health Benefits of Whey or Colostrum Supplementation in Adults ≥35 Years; a Systematic Review

et al. 2020

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Food-health claims are an important method of translating nutrition research to consumers. Whey and colostrum are thought to exert health benefits to adults, but it is unclear what measurable, objective health benefits they impart. This review aimed to identify the objective health benefits of bovine whey or colostrum-based beverages to healthy adults aged ≥35 years to substantiate a food-health claim. Seven databases were systematically searched. Eligible articles were RCTs that involved healthy adults aged ≥35 years, consuming whey or colostrum in beverage form and measuring objective health markers. Quality assessment and data extraction was conducted in duplicate. The searches identified 9943 papers and 16 were included in this review; 13 studies, reported across 15 papers, related to whey, one study to colostrum. The outcomes identified were body composition, bone mineral density, biochemical markers, such as blood glucose and lipids, and muscle strength and synthesis. Heterogeneous outcomes, high risk of bias and inconsistent findings resulted in inconclusive evidence to substantiate a food-health claim. Clearer reporting and consensus on a minimum set of objective measures would allow for more robust recommendations regarding food-health claims. Protecting consumers from misleading health claims will require collaboration between regulators, researchers, and the food industry.

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Section: Discussionmentioning

confidence: 99%

Health Benefits of Whey or Colostrum Supplementation in Adults ≥35 Years; a Systematic Review

et al. 2020

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“…While food supplements are addressed to compensate, if any, a lack of micro/ macro nutrients in the body, a nutraceutical must have a proven pharmacological effect and rationale to be used in a pathological condition. Nutraceuticals are generally reported to have good safety profile with few unwanted side effects and better bioavailability, even if new studies stress the possible adverse effects of both food supplements and nutraceuticals with reference to interactions with pharmaceuticals and/or food [4]. Their application area ranges from metabolic syndrome and inflammation control to Alzheimer's disease [5][6][7][8][9][10][11].…”

Section: Nutraceuticals: Beyond the Diet Before The Drugsmentioning

confidence: 99%

Nutraceuticals - shedding light on the grey area between pharmaceuticals and food

Santini

Novellino

2018

Expert Review of Clinical Pharmacology

161

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“…Some supplements may provide health benefits [12][13][14]. However, supplement use can result in serious adverse health outcomes such as renal and liver injury [7,[15][16][17][18][19][20][21][22][23][24], particularly for patients with pre-existing liver or kidney disease [7,19]. Studies have shown that while rare, the most serious supplement-drug interactions can result in renal and liver toxicity, cardiotoxicity, cardiovascular collapse, hypovolemic shock, and even death [21][22][23].…”

Section: Categorization Of Supplementsmentioning

confidence: 99%

Factors Related to Disclosure and Nondisclosure of Dietary Supplements in Primary Care, Integrative Medicine, and Naturopathic Medicine

Guzman¹,

Paterniti²,

Liu³

et al. 2019

J Fam Med Dis Prev

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Background: Patients infrequently disclose use of dietary supplements to providers. Little is known about factors that motivate patients to disclose supplement use. The study aimed to identify reported factors motivating patients' disclosure and nondisclosure of dietary supplement use and explore differences based on type of supplement and provider practice. Methods: Mixed methods study combining qualitative content analysis of semi-structured interviews with statistical analyses to assess differences in identified factors by provider practice type and supplement type. Seventy-eight English-speaking patients who reported taking 466 dietary supplements in the previous 30 days were recruited from primary care and Complementary and Alternative Medicine (CAM), and Integrative Medicine (IM) offices in Southern California. Results: We identified nine themes related to disclosure and nine related to nondisclosure of dietary supplement use. Major themes were features of the office visit, circumstances in patient health and medical care, and provider/patient characteristics. The most commonly raised theme promoting disclosure of supplement use was provider inquiry. Patients associate disclosure with having concerns about a supplement but also with annual physical exams and some routine topics of discussion, including self-care, lab results, and new medication prescriptions. Themes related to nondisclosure included lack of provider inquiry, features of the office visit, such as supplements being unrelated to the visit purpose, and patients' convictions that supplements are safe or not important to discuss. Themes did not vary by supplement type. Primary care patients were more likely than CAM/IM patients to attribute nondisclosure to convictions that supplements were beneficial, not worth mentioning, or equivalent to food (p ≤ 0.001). Conclusions: When providers fail to ask directly about dietary supplement use, disclosure is often an impromptu decision that is driven by the content of provider-patient interactions. Ensuring disclosure of dietary supplement use to prevent potential drug-supplement interactions or adverse health outcomes likely requires consistent, proactive provider queries about supplement use.

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Adverse Effects of Nutraceuticals and Dietary Supplements

Cited by 238 publications

References 130 publications

Health Benefits of Whey or Colostrum Supplementation in Adults ≥35 Years; a Systematic Review

Health Benefits of Whey or Colostrum Supplementation in Adults ≥35 Years; a Systematic Review

Nutraceuticals - shedding light on the grey area between pharmaceuticals and food

Factors Related to Disclosure and Nondisclosure of Dietary Supplements in Primary Care, Integrative Medicine, and Naturopathic Medicine

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