Adverse Effects of Nitroxynil in comparison with Levamisole on Male Rats

El-Sawy, Abd El-Salam F.; El-Maddawy, Zeynab Kh.; Mohamed, Nagah A. A.

doi:10.5455/ajvs.199012

Cited by 2 publications

(6 citation statements)

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“…The findings regarding serum urea and creatinine are agreed with the results recorded by Elsawy, Elmaddawy [22] who recorded the levels of serum urea and creatinine which were significantly increased in nitroxynil treated rats. Our results showed that albendazole and nitroxynil treated groups showed a significant decrease in GSH after one day, one week and two weeks of treatment compared to control group.…”

Section: Discussionsupporting

confidence: 90%

“…The results of serum ALT and AST are in accordance to the results recorded by Elsawy, Elmaddawy [22] who stated that the activities of ALT and AST were significantly increased in nitroxynil treated rats after the 4 th and 8 th weeks of dosing.…”

Section: Discussionsupporting

confidence: 90%

“…The reported histopathological findings by nitroxynil on the liver are in agreement with that reported by Elsawy, Elmaddawy [22]who recorded a congestion of the portal blood vessel, hepatocytic, hemorrhages and perivascular lymphocytic aggregation in rats liver post-nitroxynil treatment.…”

Section: Pedrosa De Bem [44]locatelli Pedrosa [45]supporting

confidence: 91%

“…The results recorded in kidney of the nitroxynil treated group showed necrotic glomeruli signs of acute inflammation with tubular dilatation and tubular cast. These results are in accordance with Elsawy, Elmaddawy [22]who studied the histopathological changes of kidney in nitroxynil treated rats and indicated that there was cortical and medullary congestion, hemorrhages, lymphocytic infiltration, tubular dilation and tubular cast and excess of luminal casts in the cortical tubule at 8ththe weeks of the treatment. The existing results are matched with Alfonso, Marrero [57]who indicated that there was dilatation in renal tubules and hemorrhage after nitroxynil treatment.…”

Section: Pedrosa De Bem [44]locatelli Pedrosa [45]supporting

confidence: 87%

“…The current results of rabbit duodenum treated with nitroxynil was agreed with that shown by Sobbhy [59] and Alfonso, Marrero [57] who indicated that nitroxynil exerted congestion, hemorrhages in many organs. Similarly, Elsawy, Elmaddawy [22]stated that nitroxynil induced some histopathological changes in both liver and kidney of treated rats.…”

Section: Pedrosa De Bem [44]locatelli Pedrosa [45]mentioning

confidence: 90%

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Adverse effect of Nitroxynil and Albendazole on rabbits

Elalfy

Hassan

Amer

2021

Mansoura Veterinary Medical Journal

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The present study aims to investigate the possible adverse effects of the subcutaneous injection of nitroxynil and oral administration of albendazole in rabbits. Design: Randomized controlled experimental study. Animals: 18 New Zealand rabbits of 1.50 ± 0.5 kg body weight, were allocated randomly into three groups (n=6). Procedures: Group A served as control, the group B was treated with albendazole (20 mg /kg B. wt.) orally and the group C was treated with nitroxynil (10mg /kg B. wt.) subcutaneously. Blood samples were collected at 1 st , 7 th and 14 th days post drugs administration for hematological and biochemical determination. In addition, histopathological examination of liver, kidney and intestine specimens were performed. Results:The obtained results evoked a significant decrease in RBCs, PCV, Hb, WBCs, lymphocytes , neutrophils, GSH and catalase values in group B and C compared with that group A. On the other hand, group B and C elevated serum ALT, AST, urea, creatinine, and MDA significantly (P ≤0.05) compared with group A.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Pedrosa De Bem [44]locatelli Pedrosa [45]supporting

confidence: 91%

Section: Pedrosa De Bem [44]locatelli Pedrosa [45]supporting

confidence: 87%

Section: Pedrosa De Bem [44]locatelli Pedrosa [45]mentioning

confidence: 90%

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