Adverse effects of mosquito coil smoke on lung, liver and certain drug metabilishing enzymes in male wistar albino rats

Okine, Lkn; Nyarko, AK; Armah, GE; Awumbila, B.; Owusu, K; Set-Soafia, S; Ofosuhene, Mark

doi:10.4314/gmj.v38i3.36001

Cited by 12 publications

(17 citation statements)

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“…, [13] also documented peribronchial lymphoid hyperplasia, vascular congestion and pulmonary edema at 16 weeks of exposure, which favours our study. Okine LKN et al (2004), [14] reported thickening of bronchiolar epithelial wall, consolidation in alveoli with signs of pulmonary edema, emphysema and bronchopneumonia after 6 weeks of exposure, in concordance with our study, that also shows features of bronchopneumonia and emphysema in exposed rats. Taiwo (2008), [15] documented pneumonia in exposed rats that is consistent with our findings but they also reported thrombosis, vasculitis and anthracosis that were not documented in our study.…”

Section: Discussionsupporting

confidence: 92%

Histopathological and Haematological Effects of Mosquito Coil Smoke on Lungs - An Experimental Study on Albino Rats

Syed

Balowria²,

Tousia³

et al. 2019

AANAT

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Section: Discussionsupporting

confidence: 92%

Histopathological and Haematological Effects of Mosquito Coil Smoke on Lungs - An Experimental Study on Albino Rats

Syed

Balowria²,

Tousia³

et al. 2019

AANAT

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“…The lung tissue of rats exposed to mosquito coil smoke for the longest period (16 weeks) showed peribronchial lymphoid hyperplasia, interstitial and congestion pulmonary oedema; this observation has been documented by Okine et al 2004. Oedema could have resulted from the inflammatory processes taking place as a result of irritation of various organs by toxic chemicals from coil smoke.…”

Section: Discussionmentioning

confidence: 78%

Efectos toxicológicos del uso prolongado e intenso de emisiones de espirales contra mosquitos en ratas y sus implicaciones sobre el control de la malaria

Idowu

Aimufua

Ejovwoke

et al. 2013

RBT

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Efectos toxicológicos del uso prolongado e intenso de emisiones de espirales contra mosquitos en ratas y sus implicaciones sobre el control de la malaria. Mosquito coil is a vector control option used to prevent malaria in low income counties, while some studies have addressed this issue, additional reseach is required to increase knowledge on the adverse health effects caused by the prolonged use of coils. In this study we investigated the toxicological effects of fumes from two locally manufactured mosquito coil insecticides (with pyrethroids: transfluthrin and d-allethrin as active ingredients) on male albino rats. For this, we recorded the haematological and biochemical indices, and made histopathology and mutagenicity evaluations in rats exposed to mosquito fumes during 2, 4, 8, 12 and 16 week periods. Haematological determination was performed using automated hematology analyzer to determine White Blood Cell (WBC), Packed Cell volume (PCv), Red Blood Cell (RBC) and Platelet (PLT) counts, while biochemical evaluations were determined using available commercial kits. Gross histopathological changes were studied for the kidney, liver and lungs in sacrificed rats. The rat sperm head abnormalities assessment was used to evaluate mutagenicity. Mosquito coil fumes produced significant increase (P<0.05) in the levels of total protein, total albumin and bilirubin, when animals were exposed from two weeks to 16 weeks with transfluthrin. Similarly, elevation in the activities of aspartate amino transferase, alanine amino transferase and alanine phosphatase, increased significantly in both insecticides. Increase in WBC, RBC and PCv were recorded for all the exposure periods, however PLT count showed no significant increase (P>0.05). Mutagenicity assessment revealed sperm abnormality was statistically significant (P<0.05) compared with the control at 8, 12 and 16 weeks post exposure to transfluthrin. Histological studies revealed severe lung damage evidenced by interstitial accumulations, pulmonary oedema and emphysema in exposed rats. Intracellular accumulations and severe sinusoidal congestion of liver cells were observed from 12 weeks exposure, indicating liver damage. Our studies indicate that mosquito coil fumes do initiate gradual damage to the host. These pathological effects must be taken into consideration by the malaria control program, particularly when regulating their long term and indoor usage. Rev.

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“…The smoke of mosquito coil contain polycyclic aromatic hydro carbons, Aldehydes and Ketones (4) they are known to cause metaplasia of bronchial epithelial cells and morphological alterations of alveolar macrophages both these changes lead on to low grade inflammatory responses bringing about restrictive and obstructive changes. In addition there is also thickening bronchial epithelial wall, alveolar thickening and consolidation of alveolar areas as a result exposure to mosquito coil smoke (9) which is exaggerating the restrictive and also bringing obstructive changes.…”

Section: Discussionmentioning

confidence: 99%

Effects of Mosquito Repellents on Pulmonary Functions

Venkatesh¹,

Puneeth²

2014

jemds

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Mosquito bite transmits diseases like Malaria, Filaria, Dengue etc. and usage of repellents is very common and has been in use for a long time. The smoke contains Polyaromatic Hydrocarbons, Aldehydes and Ketones. Review of literature has shown ill effects of this smoke. Hence we intended to study the effect of mosquito repellents on lung functions. This study would be important to create awareness regarding usage of mosquito repellent and to adapt to non-harmful methods of preventing mosquito bites. PFT parameters FVC, FEV1, FEV1/ FVC %, FEF 25-75 and PEFR were recorded in mosquito coil users, liquidator's users and controls that used neither. It was found that FVC and FEV1 were significantly less in coil and liquidators users compared to controls (P < 0.05). Also it was found that in both coil users and liquidator users FVC, FEV1, FEF 25 -75 and PEFR and showed progressive decline with increased duration of usage (P < 0.05). Hence it was concluded that mosquito coils and liquidators can cause progressive decline in lung functions. Alternative methods to combat mosquito menace, like personal and environmental hygiene and non-chemical methods of protection are therefore recommended.

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Adverse effects of mosquito coil smoke on lung, liver and certain drug metabilishing enzymes in male wistar albino rats

Cited by 12 publications

References 0 publications

Histopathological and Haematological Effects of Mosquito Coil Smoke on Lungs - An Experimental Study on Albino Rats

Histopathological and Haematological Effects of Mosquito Coil Smoke on Lungs - An Experimental Study on Albino Rats

Efectos toxicológicos del uso prolongado e intenso de emisiones de espirales contra mosquitos en ratas y sus implicaciones sobre el control de la malaria

Effects of Mosquito Repellents on Pulmonary Functions

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