Adverse effects of enalapril in the Studies of Left Ventricular Dysfunction (SOLVD)

Kostis, John B.; Shelton, Brent J.; Gosselin, Gilbert; Goulet, Claude; Hood, William B.; Kohn, R; Kubo, Spencer H.; Schron, Eleanor B.; Weiss, Melvin B.; Willis, Park W.; Young, James B.; Probstfield, Jeffrey L.

doi:10.1016/s0002-8703(96)90365-8

Cited by 134 publications

(80 citation statements)

References 20 publications

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“…631,632 Women may also have a different safety profile than men, as evidenced by their higher risk of ACEI-induced cough. 633 The conflicting data regarding the efficacy of digoxin in women suggests that if it is prescribed, particular attention should be paid to dosing and renal function. 379 Currently, great efforts are being made (and mandated) to include a higher proportion of women in government-sponsored trials.…”

Section: Women and Menmentioning

confidence: 99%

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

Hunt¹,

Abraham²,

Chin³

et al. 2009

Circulation

1,913

757

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Section: Women and Menmentioning

confidence: 99%

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

Hunt¹,

Abraham²,

Chin³

et al. 2009

Circulation

1,913

757

View full text Add to dashboard Cite

“…Some analyses have suggested that women with HF, particularly with asymptomatic reduced LVEF, may not show survival benefits from ACE inhibition (514,515). Women may also have a different safety profile than men, as evidenced by their higher risk of ACEI-induced cough (516). The conflicting data regarding the efficacy of digoxin in women suggests that if it is prescribed, particular attention should be paid to dosing and renal function (314).…”

Section: Hunt Et Al Acc/aha Practice Guidelines E199mentioning

confidence: 99%

ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult

Hunt

Abraham

Chin³

et al. 2005

Circulation

1,960

773

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“…Indeed, we did find that although women were more likely to continue treatment with other antihypertensive drugs than men, they were significantly more likely to discontinue ACE inhibitor therapy than men (49 vs. 41%), a finding consistent with that in other studies (18 -23). Although there is insufficient clinical information in the databases used for this study to explore why women had higher rates of ACE inhibitor discontinuation, reports from clinical trials and registries have consistently documented that women are at higher risk of ACE inhibitor-induced cough than men (21)(22)(23). The reasons behind this and the optimal strategy to minimize potential adverse effects with ACE inhibition in women remain active areas of research.…”

Section: Results -Frommentioning

confidence: 99%

Antihypertensive Medication Prescribing in 27,822 Elderly Canadians With Diabetes Over the Past Decade

McAlister

Campbell²,

Duong-Hua³

et al. 2006

Diabetes Care

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OBJECTIVE -The purpose of this study was to examine whether prescribing practices for elderly individuals with diabetes and hypertension changed over the past decade. RESEARCH DESIGN AND METHODS -We linked the Ontario Diabetes Databaseand four administrative databases in Ontario, Canada, to identify 27,822 patients Ͼ65 years of age who had diabetes and were newly treated for hypertension between 1 January 1995 and 31 December 2001. All patients were followed for 2 years after their initial antihypertensive medication prescription.RESULTS -The 27,822 patients in this study (mean age 72 years, 51% men) were treated with oral hypoglycemic agents alone (n ϭ 17,128 patients, 62%), insulin alone (n ϭ 2,346, 8%), both oral hypoglycemic agents and insulin (n ϭ 2,205, 8%), or diet alone (n ϭ 6,143, 22%). Management within the first 2 years of hypertension diagnosis consisted of antihypertensive monotherapy in 20,183 patients (73%), two antihypertensive drugs in 6,207 (22%), and three or more drugs in 1,432 (5%); the most frequently chosen antihypertensive drugs were ACE inhibitors (68%), thiazides (15%), and calcium channel blockers (9%). Between 1995 and 2001, physician prescribing practices changed: the population-adjusted rates of antihypertensive drug prescribing increased by 46% (95% CI 33-55%), the proportion of initial antihypertensive prescriptions for ACE inhibitors increased from 54 to 76% (P Ͻ 0.0001), and the use of multiple antihypertensive agents within the first 2 years of diagnosis increased from 21 to 32% (P Ͻ 0.0001).CONCLUSIONS -Antihypertensive prescribing patterns in elderly individuals with diabetes changed over the past decade in Ontario in directions consistent with the evolving evidence base. Diabetes Care 29:836 -841, 2006A lthough most patients with diabetes die of atherosclerotic disease (1), practice audits consistently highlight the suboptimal control of atherosclerotic risk in individuals with diabetes. In particular, numerous studies have demonstrated that few patients with diabetes have their blood pressure lowered to currently recommended targets (130/80 mmHg) (2-8), despite the fact that the benefits of aggressive blood pressure lowering may exceed those of aggressive glycemic control and that control of blood pressure has been identified by the Centers for Disease Control and Prevention as the most cost-effective intervention for reducing macrovascular risk in individuals with diabetes (9 -11).However, practice audits are typically small, drawn from highly select samples, frequently rely on patient self-report, are usually cross-sectional, and leave some questions unanswered. In particular, by focusing only on measured blood pressure levels, these audits have been unable to show whether the care gap in hypertensive individuals with diabetes is due to physician factors (such as underprescription of antihypertensive agents and/or failure to initiate treatment with multiple drugs to achieve blood pressure targets), patient factors (for example, noncompliance with medications or failure to...

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Adverse effects of enalapril in the Studies of Left Ventricular Dysfunction (SOLVD)

Cited by 134 publications

References 20 publications

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult

Antihypertensive Medication Prescribing in 27,822 Elderly Canadians With Diabetes Over the Past Decade

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