Adverse Effects of Dexamethasone Treatment in Preterm Neonates

Bos, Arie; Oetomo, Sidarto Bambang

doi:10.1007/978-3-642-80227-0_5

Cited by 1 publication

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“…Corticosteroids administered before birth proved to significantly reduce morbidity and mortality from the respiratory distress syndrome and periventricular hemorrhage (Avery et al, 1985;Crowley, 1995). After birth, however, the effects of such therapy are equivocal (for review, Bos & Bambang Oetomo, 1996). A side effect of treatment before birth is interference with CNS development as indicated by a decrease in fetal body movements, breathing activity, and fetal heart rate variability (Derks et al, 1995;Mulder et al, 1994;Bos et al, 1984), and in the neonate, on the quality of General Movements (Bos et al, 1998).…”

Section: Corticosteroid Treatment In Ratsmentioning

confidence: 99%

Clumsiness and Disturbed Cerebellar Development: Insights From Animal Experiments

Gramsbergen¹

2003

Neural Plasticity

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Cerebellar functioning has been implied in the fine adjustments of muscle tone, in the coordination and the feed-forward control of movements and posture, as well as in the establishment and performance of motor skills. The cerebellar cortex in mammals develops late in neuro-ontogeny and an extrapolation from experimental results indicates that in the human the proliferation of the granule cells and the development of circuitry in the cerebellar cortex starts only in the last trimester of pregnancy and lasts until beyond the first birthday. This late development makes the cerebellar development particularly vulnerable to situations like an insufficient supply of nutrients, which may follow placental dysfunction, or to side effects of pharmacological treatments like the administration of corticosteroids in the postnatal period. We studied whether such situations might also lead to motor impairments. In rats, the effects of undernutrition during the brain growth spurt were investigated as well as those of corticosteroids administered in a period that is analogous to the 7th to 8th month of pregnancy in the human. Both these interferences affect cerebellar development and our results in rats indicate that they also lead to retardations in the, emergence of certain reflexes, as well as to longer lasting motor impairments during locomotion. Extrapolation of these results strongly suggests that a disturbed cerebellar development should be considered as an important etiological factor in clumsiness in human children.

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Section: Corticosteroid Treatment In Ratsmentioning

confidence: 99%

Clumsiness and Disturbed Cerebellar Development: Insights From Animal Experiments

Gramsbergen¹

2003

Neural Plasticity

View full text Add to dashboard Cite

show abstract

Adverse Effects of Dexamethasone Treatment in Preterm Neonates

Cited by 1 publication

References 34 publications

Clumsiness and Disturbed Cerebellar Development: Insights From Animal Experiments

Clumsiness and Disturbed Cerebellar Development: Insights From Animal Experiments

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