Adverse effects of circadian desynchrony on the male reproductive system: an epidemiological and experimental study

Liu, Kun; Hou, Guizhong; Wang, Xiaogang; Chen, Huatao; Shi, Fuquan; Liu, Chang; Zhang, Xi; Han, Fei; Yang, Huan; Zhou, Nina; Ao, Lin; Liu, Jinyi; Cao, Jia; Chen, Qing

doi:10.1093/humrep/deaa101

Cited by 25 publications

(19 citation statements)

References 36 publications

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“…They found that rotating shift work is related to lower sperm counts. They also found negative effects in sperm count non-work-related causes, like long time use of the mobile phone [ 117 ].…”

Section: Lifestylementioning

confidence: 99%

Male subfertility and oxidative stress

et al. 2021

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To date 15% of couples are suffering from infertility with 45–50% of males being responsible. With an increase in paternal age as well as various environmental and lifestyle factors worsening these figures are expected to increase. As the so-called free radical theory of infertility suggests, free radicals or reactive oxygen species (ROS) play an essential role in this process. However, ROS also fulfill important functions for instance in sperm maturation. The aim of this review article is to discuss the role reactive oxygen species play in male fertility and how these are influenced by lifestyle, age or disease. We will further discuss how these ROS are measured and how they can be avoided during in-vitro fertilization.

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Section: Lifestylementioning

confidence: 99%

Male subfertility and oxidative stress

et al. 2021

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“…One of the major reasons for this controversy may be that shift work consists of different work schedules, e.g., permanent night work and rotating shift work, which may lead to different health effects. A study of 1346 men in the community showed that rotating shift workers, but not permanent night workers, had lower sperm count compared to day workers ( Liu K. et al, 2020 ). In the same publication, social jetlag between work days and free days was found to be quantitatively associated with decreased sperm count in 796 male university students.…”

Section: Circadian Pathophysiology In Complex Diseasesmentioning

confidence: 99%

“…Moreover, when pregnant rats were exposed to constant light, their male offspring showed a decrease in numerous indicators, including testosterone levels, number of Sertoli cells, sperm count and normal sperm count ( Ogo et al, 2020 ). To simulate exposure to rotating shift work, a recent study put male mice into rotating light/dark cycles ( Liu K. et al, 2020 ). The authors found that the sperm count of the male mice decreased, while the circadian oscillation of sperm count was not affected.…”

Section: Circadian Pathophysiology In Complex Diseasesmentioning

confidence: 99%

“…The current knowledge around specific details of molecular events following the input of circadian misalignment is limited. Liu K. et al (2020) suggested that the homologous recombination pathway was disrupted following circadian desynchrony in a rodent model. It remains unknown whether any of these molecular events are induced by unique signals.…”

Section: Circadian Pathophysiology In Complex Diseasesmentioning

confidence: 99%

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Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease

Xin

Yuan

et al. 2021

Front. Genet.

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The circadian clock coordinates physiology, metabolism, and behavior with the 24-h cycles of environmental light. Fundamental mechanisms of how the circadian clock regulates organ physiology and metabolism have been elucidated at a rapid speed in the past two decades. Here we review circadian networks in more than six organ systems associated with complex disease, which cluster around metabolic disorders, and seek to propose critical regulatory molecules controlled by the circadian clock (named clock-controlled checkpoints) in the pathogenesis of complex disease. These include clock-controlled checkpoints such as circadian nuclear receptors in liver and muscle tissues, chemokines and adhesion molecules in the vasculature. Although the progress is encouraging, many gaps in the mechanisms remain unaddressed. Future studies should focus on devising time-dependent strategies for drug delivery and engagement in well-characterized organs such as the liver, and elucidating fundamental circadian biology in so far less characterized organ systems, including the heart, blood, peripheral neurons, and reproductive systems.

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“…For decades, the clinical implications of shiftwork on reproductive dysfunction have been examined. Most of this work has focused on the female reproductive system, although some reports also show an impact on male reproductive status [ 2 , 3 ]; however, this literature is less explored. While several studies have provided strong correlational relationships between female shift workers and reproductive deficits throughout the reproductive cycle, including menstrual/ovulatory cycling [ 4 , 5 , 6 , 7 , 8 , 9 ], fertility and pregnancy [ 10 , 11 , 12 , 13 ], as well as labor and birth [ 14 , 15 , 16 , 17 , 18 ], there are still significant gaps in our knowledge of the mechanisms by which shiftwork may cause reduced reproductive function.…”

Section: Introductionmentioning

confidence: 99%

Shiftwork and Light at Night Negatively Impact Molecular and Endocrine Timekeeping in the Female Reproductive Axis in Humans and Rodents

Yaw

McLane-Svoboda

Hoffmann

2020

IJMS

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Shiftwork, including work that takes place at night (nightshift) and/or rotates between day and nightshifts, plays an important role in our society, but is associated with decreased health, including reproductive dysfunction. One key factor in shiftwork, exposure to light at night, has been identified as a likely contributor to the underlying health risks associated with shiftwork. Light at night disrupts the behavioral and molecular circadian timekeeping system, which is important for coordinated timing of physiological processes, causing mistimed hormone release and impaired physiological functions. This review focuses on the impact of shiftwork on reproductive function and pregnancy in women and laboratory rodents and potential underlying molecular mechanisms. We summarize the negative impact of shiftwork on female fertility and compare these findings to studies in rodent models of light shifts. Light-shift rodent models recapitulate several aspects of reproductive dysfunction found in shift workers, and their comparison with human studies can enable a deeper understanding of physiological and hormonal responses to light shifts and the underlying molecular mechanisms that may lead to reproductive disruption in human shift workers. The contributions of human and rodent studies are essential to identify the origins of impaired fertility in women employed in shiftwork.

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Adverse effects of circadian desynchrony on the male reproductive system: an epidemiological and experimental study

Abstract: Abstract STUDY QUESTION Is circadian desynchrony a risk factor of male reproductive damage in semen parameters and/or reproductive hormones? SUMMARY ANSWER Circadian desynchrony correlates with decrease of sperm count, which was improved when circadian desynchrony… Show more

Cited by 25 publications

References 36 publications

Male subfertility and oxidative stress

Male subfertility and oxidative stress

Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease

Shiftwork and Light at Night Negatively Impact Molecular and Endocrine Timekeeping in the Female Reproductive Axis in Humans and Rodents

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