Adverse Effects of Amoxicillin for Acute Lower Respiratory Tract Infection in Primary Care: Secondary and Subgroup Analysis of a Randomised Clinical Trial

Tandan, Meera; Vellinga, Akke; Bruyndonckx, Robin; Little, Paul; Verheij, Theo; Butler, Christopher Collett; Goossens, Herman; Coenen, Samuel

doi:10.3390/antibiotics6040036

Cited by 6 publications

(4 citation statements)

References 23 publications

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“…In addition, adverse events appeared to have been collected not systematically and, even after correspondence with authors, often their assessment methods remained unclear (e.g. definitions, if asked or self‐reported, when and how): this could explain the lower reported rates if compared with the medical literature (Tandan et al., ). Moreover, there was generally a poor report of periodontal conditions of participants and differences in the experience of the operators and in pre‐ and post‐operative procedures (e.g.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic prophylaxis at dental implant placement: Which is the best protocol? A systematic review and network meta‐analysis

Romandini

Tullio

Congedi

et al. 2019

J Clinic Periodontology

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Aim: This systematic review of randomized controlled trials (RCTs) aims to answer to the following question: "In patients undergoing dental implant placement, which is the best antibiotic prophylaxis protocol to prevent early failures?" Materials and Methods: The MEDLINE, SCOPUS, CENTRAL and Web of Knowledge electronic databases were searched in duplicate for RCTs up to July 2017. Additional relevant literature was identified through (i) handsearching on both relevant journals and reference lists, and (ii) searching in databases for grey literature. A network metaanalysis (NMA) was conducted, and the probability that each protocol is the "Best" was estimated.Results: Nine RCTs were included, with a total of 1,693 participants. Due to the few events reported, it was not possible to conduct a NMA for adverse events, therefore it was conducted only for implant failures (IF). The protocol with the highest probability (32.5%) of being the "Best" one to prevent IF was the single dose of 3 g of amoxicillin administered 1 hr pre-operatively. Even if the single pre-operative dose of 2 g of amoxicillin is the most used, it achieved only a probability of 0.2% to be the "Best" one. Conclusions:Basing on the available RCTs, the use of antibiotic prophylaxis is protective against early implant failures. Whenever an antibiotic prophylaxis is needed, there is still insufficient evidence to confidently recommend a specific dosage. The use of post-operative courses does not seem however to be justified by the available literature. Prospero registration number: CRD42015029708. K E Y W O R D S adverse events, antibiotic prophylaxis, early failures, early implant failures, implant placement, implant survival, network meta-analysis, penicillins, side effects, systematic review | 383 ROMANDINI et Al.

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Section: Discussionmentioning

confidence: 99%

Antibiotic prophylaxis at dental implant placement: Which is the best protocol? A systematic review and network meta‐analysis

Romandini

Tullio

Congedi

et al. 2019

J Clinic Periodontology

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“…The unnecessary or inappropriate prescription of antibiotics can have broad negative consequences, including contributing to the rise and spread of antimicrobial resistance (itself considered one of the biggest threats to global health) [7,8] and unnecessarily exposing the patient to the risk of adverse events (including life-threatening events, e.g. anaphylaxis, Stevens-Johnson syndrome, Clostridium difficile infection) [9][10][11]. As well as negatively affecting patient health and care (at both the individual and population level), these effects are also associated with significant economic costs [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

FebriDx®: A Rapid Diagnostic Test for Differentiating Bacterial and Viral Aetiologies in Acute Respiratory Infections

Shirley

2019

Mol Diagn Ther

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FebriDx ® is a rapid, point-of-care diagnostic test that is designed to aid in the differentiation of bacterial and viral acute respiratory infections (ARIs), thus helping to guide decisions regarding the prescription of antibiotics in the outpatient setting. FebriDx carries a CE mark for use in the EU and is also approved in several other countries, including Canada, Saudi Arabia and Singapore. It is indicated for use in patients > 2 years old with symptoms consistent with a community-acquired ARI. The test involves the use of an immunoassay on a fingerstick blood sample to provide simultaneous, qualitative measurement of elevated levels of C-reactive protein (CRP) and myxovirus resistance protein A (MxA). In two prospective, multicentre studies in patients with acute upper respiratory tract infections, FebriDx was shown to be both sensitive and specific in identifying patients with a clinically significant infection and in differentiating between infections of bacterial and viral aetiology. The test is simple, requires no additional equipment and produces actionable results in ~ 10 min. As was demonstrated in a small, retrospective analysis, FebriDx results can help guide (improve) antibiotic prescribing decisions. Reducing the unnecessary or inappropriate prescription of antibiotics for ARIs of probable viral aetiology is important for antibiotic stewardship and can also reduce the unnecessary exposure of patients to the risk of antibiotic-related adverse events. FebriDx thus represents a useful diagnostic tool in the outpatient setting. FebriDx®: a summaryA simple, all-in-one, diagnostic test to assist in the diagnosis of bacterial or viral ARIs by measuring the host response to infection Based on a rapid immunoassay that provides simultaneous, qualitative measurement of elevated levels of CRP and MxA Sensitive and specific in identifying patients with a clinically significant infection and in differentiating between infections of bacterial and viral aetiology Produces actionable results in ~ 10 min which can be used to help guide antibiotic prescribing decisions turer of FebriDx was also offered an opportunity to review this article. Changes resulting from comments received were made on the basis of scientific and editorial merit.

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“…Pemberian tetrasiklin dapat diberikan pada anak yang berusia >8 tahun dengan dosis 25-50 mg/kg/hari per oral dalam dosis terbagi setiap 6 jam (maksimal:4g/hari) [25]. Menurut Arianti dalam Ria, antibiotik tetrasiklin adalah salah satu antibiotik yang berpotensi kelainan pada gigi yang berubah menjadi kecoklatan [28].…”

Section: Tabel 2 Distribusi Pengetahuanunclassified

Overview of Community Knowledge about The Use of Antibotic in Blungkan Hamlet, Sendangrejo Village, Lamongan Sub-district, Lamongan District

Pratiwi,

Nasyanka

2024

Pharmasci

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Antibiotics are medications that combat bacterial illnesses. There are several negative health outcomes associated with the current epidemic of antibiotic resistance, including higher rates of illness and death, higher healthcare expenditures, and treatment failures. In 2015, there were an increase of 50 million unnecessary antibiotic prescriptions (Unnescecery prescribing) from 150 million, and this number continues to increase every year. Thus, the number of bacteria that are resistant to antibiotics is increasing. This study aims to determine the extent of public awareness on the utilization of antibiotics in Dusun Blungkan, Sendangrejo village, Lamongan district. The design of this research is descriptive research and data collection using questionnaires with Cronbach's alpha value of 0.83 (>0.60) then the questionnaire is declared reliable that covers 7 domains of knowledge namely understanding antibiotics, antibiotic examples, antibiotics use, dosage, contraindications, side effects, and antibiotic resistance. The results showed that in Dusun Blungkan, Sendangrejo Village, Lamongan District, and Lamongan Province there are 21 (70%) people who are aware of the use of antibiotics. Out of 30 respondents, 21 people (70%) have sufficient knowledge, 7 people (23.3%) have less knowledge, and 2 people (6.7%) have good knowledge. Controlled use of antibiotics can prevent resistance. Therefore, accurate information about the importance of antibiotics and how to use antibiotics properly and correctly is needed, as well as more wisdom in using them to avoid unexpected side effects.

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Adverse Effects of Amoxicillin for Acute Lower Respiratory Tract Infection in Primary Care: Secondary and Subgroup Analysis of a Randomised Clinical Trial

Cited by 6 publications

References 23 publications

Antibiotic prophylaxis at dental implant placement: Which is the best protocol? A systematic review and network meta‐analysis

Antibiotic prophylaxis at dental implant placement: Which is the best protocol? A systematic review and network meta‐analysis

FebriDx®: A Rapid Diagnostic Test for Differentiating Bacterial and Viral Aetiologies in Acute Respiratory Infections

Overview of Community Knowledge about The Use of Antibotic in Blungkan Hamlet, Sendangrejo Village, Lamongan Sub-district, Lamongan District

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