Adverse effects of air pollution‐derived fine particulate matter on cardiovascular homeostasis and disease

Bae, Hye Ryeong; Chandy, Mark; Aguilera, Juan; Smith, Eric; Nadeau, Kari; Wu, Joseph C.; Paik, David T.

doi:10.1016/j.tcm.2021.09.010

Cited by 18 publications

(11 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the NTS-100 was used to cut skin and muscle tissue, the average particle diameters were >10 µm (122.223±34.034 and 29.192±6.518 µm, respectively), which was significantly larger than the average particle diameters with the PB (2.507±0.277 and 2.625±0.639 µm, respectively) and the ES (0.775±0.382 and 0.942±0.298 µm, respectively). In addition, particles with a diameter <2.5 µm can absorb VOCs, such as polycyclic aromatic hydrocarbons and benzene, as well as heavy metals ( 3 , 20 ). When the NTS-100 was used to cut liver tissue, the average particle diameter was 2.585±0.784 µm, which was significantly larger than that for particles generated by the ES (0.988±0.690 µm).…”

Section: Discussionmentioning

confidence: 99%

“…When the NTS-100 was used to cut liver tissue, the average particle diameter was 2.585±0.784 µm, which was significantly larger than that for particles generated by the ES (0.988±0.690 µm). Furthermore, ultrafine particles are capable of penetrating cells ( 20 , 21 ). For all experimental tissue types, the average diameter of particles with the ES was <1 µm, with a certain proportion of particles being <0.1 µm.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Smoke analysis of a new surgical system that applies low-temperature plasma

Zhang¹,

Guan²,

Zhu³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

Background: The high-frequency electrotome (ES), which is widely used in surgical procedures, generates surgical smoke that is potentially hazardous to operating personnel. Previous research shows that the PlasmaBlade (PB) may be able to overcome this problem. The present study set out to analyze potentially hazardous surgical smoke generated during electrosurgery by the ES, the PB, and. a new surgical system that applies low-temperature plasma, the NTS-100.Methods: In vitro and in vivo healthy porcine models were used to compare volatile organic compounds (VOCs) and particulate matter (PM) in smoke generated by the NTS-100, the PB, and the conventional ES when cutting liver, muscle, and skin and subcutaneous tissues. The detected indexes included the VOCs in surgical smoke, the concentration and percentage of each part, the PM2.5 concentration, the mass of particles, and the diameter distribution of particles. Results:The smoke generated by the NTS-100 contained fewer hazardous components than that generated by the ES (P<0.05) and a comparable amount to that generated by the PB (P>0.05). The PM2.5 concentration and mass of particles in the smoke generated by the NTS-100 were lower than those with the ES (P<0.05 and P<0.01, respectively) and similar to those with the PB (P>0.05). The NTS-100 generated larger particles than did the ES and the PB (P<0.05).Conclusions: Surgical smoke contains harmful VOCs and PM, but the NTS-100 generated less hazardous surgical smoke than did the conventional ES and performed comparably to the PB. Therefore, using the NTS-100 may reduce the potential hazard of surgical smoke to operating room personnel.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Smoke analysis of a new surgical system that applies low-temperature plasma

Zhang¹,

Guan²,

Zhu³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

show abstract

“…Evidence suggests PM may increase the resistance and decrease the compliance of vasculature via conceivable biological mechanisms involving endothelial dysfunction and vasoconstriction . Systemic inflammatory responses and oxidative stress leading to autonomic dysfunction are also thought to play a major role in the impact of PM exposure on CV health (Bae et al 2021;Bourdrel 2021;Kephart et al 2020). Human and animal models have provided mechanistic evidence, whereby possible pathways are shown by which acute and chronic exposures to PM might disrupt haemodynamic balance favouring vasoconstriction, including autonomic imbalance and amplified release of various pro-oxidative, inflammatory, and/or haemodynamically functioning mediators (Bae et al 2021;Brook et al 2010;Giorgini et al 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Systemic inflammatory responses and oxidative stress leading to autonomic dysfunction are also thought to play a major role in the impact of PM exposure on CV health (Bae et al 2021;Bourdrel 2021;Kephart et al 2020). Human and animal models have provided mechanistic evidence, whereby possible pathways are shown by which acute and chronic exposures to PM might disrupt haemodynamic balance favouring vasoconstriction, including autonomic imbalance and amplified release of various pro-oxidative, inflammatory, and/or haemodynamically functioning mediators (Bae et al 2021;Brook et al 2010;Giorgini et al 2016). Additionally, it is thought some prooxidative elements of inhaled particles (e.g., nanoparticles, metal, organic compounds) are capable of translocating directly into the systemic circulation to facilitate direct adverse actions including systemic inflammatory responses ).…”

Section: Discussionmentioning

confidence: 99%

Residential indoor exposure to fine and ultrafine particulate air pollution in association with blood pressure and subclinical central haemodynamic markers of cardiovascular risk among healthy adults living in Perth, Western Australia

Gilbey

Reid

Zhao

et al. 2022

Air Qual Atmos Health

View full text Add to dashboard Cite

Despite that large percentages of individual daily time is spent in the home, few studies have examined the relationship between indoor particulate matter (PM) exposure in residential settings with subclinical indicators of cardiovascular risk. This cross-sectional study investigated associations between exposure to fine (PM2.5) and ultrafine (UFP) PM in domestic indoor environments, with central blood pressure (BP) and component BP measures (pulse pressure, augmented pressure [AP], augmentation index [AIx], mean arterial pressure, pulse wave velocity [PWV]) in 40 non-smoking, otherwise healthy adults (58% women) living in Perth, Western Australia. Overall, in adjusted models, an interquartile range (IQR) increase in PM2.5 was associated with a 3.2 mmHg (95% confidence interval [CI]: 0.99, 5.45) higher diastolic BP, and a 1.8 mmHg lower AP (95%CI: − 3.63, − 0.01) and 0.4 m/s PWV (95%CI: − 0.80, − 0.08), respectively. For the UFP fraction, an IQR increase was associated with a 5.2% higher AIx (95%CI: 0.51, 9.97) and a 0.6 m/s lower PWV (95%CI: − 1.00, − 0.11).When stratified by sex, higher UFP concentrations were associated with higher DBP and lower PWV among women. Among men, higher UFP concentrations were associated with lower AP. Exposure to domestic indoor fine and ultrafine PM was associated with preclinical indicators of cardiovascular risk and some of these relationships were affected by sex. These findings contribute important evidence linking low-level residential indoor PM exposure with measurable impacts on cardiovascular physiology and may inform preventative recommendations as part of risk profiles for susceptible individuals.

show abstract

“…Control over air pollution in Russian cities is increasing every year, as residents are worried about the increasing smog driven by elevations in atmospheric particulate matter (PM), especially particles with aerodynamic diameters <2.5 μm (PM2.5) and 10 μm (PM 10 ). By entering the body and penetrating deep into the respiratory tract, PM causes significant harm to health [1,2].…”

Section: Introductionmentioning

confidence: 99%

Microscopic Investigation on Pm10 and Air-Cleaning Coatings Based on Nano-Tio2

Rakova¹

2023

GEOMATE

View full text Add to dashboard Cite

Fine atmospheric particles have physiological toxicity affecting human health. This study investigates the compositional and morphological properties of the particulate matter smaller than 10 μm (PM 10 ) collected from five different monitoring stations in Chelyabinsk, Russia. We used scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDS) for the investigation of PM 10 . In order to determine the possible sources of emissions of atmospheric particulate matter, a principal component analysis (PCA) was performed. The results revealed the presence of atmospheric PM 10, such as aluminosilicates, calcium particles, sulfates, and metallic particles differentiated on the basis of the chemical composition and morphological parameters. Sulfate PM 10 with metal inclusions contained Mn, Ti, Zn, Cu, and Cr. It obtained a higher content of potentially toxic elements in traffic-related S-rich particles compared with industrial-related PM 10 . It was the result of the solubilization of metals in airborne particles and increased toxicity. We obtained new coatings based on titanium nanooxide synthesized by the peroxy method for air purification from PM 2.5 and PM 10 . They were macroporous and very effective means against industrial dust and PM air pollution.

show abstract

Adverse effects of air pollution‐derived fine particulate matter on cardiovascular homeostasis and disease

Cited by 18 publications

References 91 publications

Smoke analysis of a new surgical system that applies low-temperature plasma

Smoke analysis of a new surgical system that applies low-temperature plasma

Residential indoor exposure to fine and ultrafine particulate air pollution in association with blood pressure and subclinical central haemodynamic markers of cardiovascular risk among healthy adults living in Perth, Western Australia

Microscopic Investigation on Pm10 and Air-Cleaning Coatings Based on Nano-Tio2

Contact Info

Product

Resources

About