Adverse Effects of 5-Alpha-Reductase Inhibitors: a narrative review

Abstract

Objective: Analyze adverse effects of 5–ARI’s regarding sexual health and fertility (erectile dysfunction and decreased libido); neurology and psychiatry (depressive symptoms, self-harm and suicidal ideation); endocrine, metabolic and cardiovascular (increased body fat, LDL and total cholesterol). Bibliographic review: This narrative review reports findings from various scientific articles published online, regarding the adverse effects of 5-ARI`s, often used to treat male-pattern baldness and benign prostate hyperplasia in adult males. Final considerations: Adverse effects were identified on several studies made in different populations. Thus, it is utterly important to raise public awareness of the implications associated with 5-ARI's treatment. Prescription of 5-ARI's therapy should be carefully assessed for each individual due to potential adverse effects that may occur upon its start, and drastically compromise quality of life in adult males.