Adverse effects associated with regadenoson myocardial perfusion imaging

Andrikopoulou, Efstathia; Hage, Fadi G.

doi:10.1007/s12350-018-1218-7

Cited by 11 publications

(7 citation statements)

References 47 publications

(75 reference statements)

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“…[4] Rare noncardiovascular side effects include gastrointestinal (nausea, diarrhea, and abdominal discomfort) and neurological (seizures and convulsions) symptoms. [3] Here we present a case of severe shivering and chest tightness after the administration of regadenoson, along with a physiologic explanation and proposed treatment.…”

Section: Introductionmentioning

confidence: 97%

“…Of the cardiovascular effects, chest pain and shortness of breath are frequently documented, which can be explained by selective adenosine receptor (A2A) agonism and coronary steal. [2][3] Less frequently, episodes of myocardial ischemia, atrioventricular block, and myocardial infarction have been reported. [4] Rare noncardiovascular side effects include gastrointestinal (nausea, diarrhea, and abdominal discomfort) and neurological (seizures and convulsions) symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Severe Shivering as an Adverse Effect of Regadenoson Myocardial Perfusion Imaging

Ahmad¹,

Linares²,

Valencia³

et al. 2021

Cureus

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Regadenoson myocardial perfusion imaging (MPI) is a widely used screening study for patients with an intermediate pretest probability of coronary artery disease (CAD). Via selective agonism of the adenosine A2A receptor, regadenoson can induce coronary steal, revealing stenotic vessel territory through transient ischemia. Common side effects of this medication include chest pain, shortness of breath, nausea, vomiting, atrioventricular block, seizure, and allergic reactions. Here we present a case of severe shivering and chest tightness after the administration of regadenoson, along with a physiologic explanation and treatment.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Severe Shivering as an Adverse Effect of Regadenoson Myocardial Perfusion Imaging

Ahmad¹,

Linares²,

Valencia³

et al. 2021

Cureus

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“…Despite the advantages of regadenoson over adenosine, clinicians should be aware of potential side effects. Even though the majority of adverse effects are short, benign, and spontaneously terminate, they rarely may also graduate to more serious events (e.g., symptomatic myocardial ischemia, infarction, atrioventricular block, asystole and/or seizures) ( 12 ). Regadenoson had been approved by the Food and Drug Administration in 2008 as the next stress agent for CT-MPI examination ( 13 , 14 ) whereas the approval in the Slovak Republic came over a decade later in 2019.…”

Section: Introductionmentioning

confidence: 99%

Adenosine vs. regadenoson for stress induction in dynamic CT perfusion scan of the myocardium: A single‑center retrospective comparison

Gibarti¹,

Murín²,

Huňavý³

et al. 2023

Exp Ther Med

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Cardiac computed tomography (CT) angiography offers several approaches to determine the hemodynamic severity of coronary artery obstruction. Dynamic myocardial perfusion is based on serial CT imaging of contrast flow into the myocardium and calculation of absolute myocardial perfusion rates. East-Slovak Institute of Cardiovascular Diseases has been the first center in Slovakia intensively using this modern technique to increase the quality level of non-invasive diagnosis of symptomatic patients with a low to moderate pre-test probability of ischemic heart disease. The present study included 46 patients with a mean age of 64 years (33 men and 13 women). Prior to the CT study, myocardial stress was pharmacologically (adenosine, n=15 and regadenoson, n=31) induced by vasodilatation of the coronary arteries. Hemodynamic parameters (myocardial blood flow) were evaluated in all patients following successful CT perfusion without complications, allergic reaction or other severe side effects. The present study revealed that regadenoson increased the heart rate following infusion with a higher magnitude compared with adenosine. Moreover, the effect of regadenoson was independent of patient's body mass index and was associated with a lower incidence of mild adverse effects. The present study provided further clinical evidence for a more wider use of regadenoson over adenosine.

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“…12 In this regard, it is important to point out that in appropriate scenarios, the benefits derived by patients from the information provided by MPI far outweigh the risks of radiation exposure (and other risks discussed elsewhere). [13][14][15] Funding Dr. Hage reports research grant support from Astellas Pharma and GE HealthCare. When this distinction is ignored and imaging is curtailed on a widescale (i.e., even in appropriate situations), patients are deprived of the benefits of advanced imaging and the public is put at risk of backsliding on the gains made over the last decades described above.…”

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confidence: 99%