Adverse effect of VEGFR-2 (rs1870377) polymorphism on the clinical course of COVID-19 in females and males in an age-dependent manner

Kocakap, Derya Beyza Sayın; Kaygusuz, Sedat; Aksoy, Emel; Şahin, Ömer; BAÇÇIOĞLU, Ayşe; Ekici, Aydanur; Kalpaklıoğlu, Ayşe Füsun; Ekici, M.; Gül, Serdar; Kaçmaz, Birgül; Açikgöz, Ergin Ayaşlioğlu; BEKMEZ, Sibel ALYILMAZ; Rouse, Barry T.; Azkur, Ahmet Kürşat

doi:10.1016/j.micinf.2023.105188

Cited by 2 publications

(1 citation statement)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, histopathology revealed microthrombosis, endothelial activation, and vascular hyperplasia, suggesting a role of endothelial dysfunction mediated by, among others, the VEGF/VEGFR axis in the pathogenesis of severe COVID-19 [44]. Another study identified several VEGFR polymorphisms that were associated with poorer clinical outcomes [45].…”

Section: Discussionmentioning

confidence: 99%

VEGFR and DPP-IV as Markers of Severe COVID-19 and Predictors of ICU Admission

Pius-Sadowska,

Kulig,

Niedźwiedź

et al. 2023

IJMS

View full text Add to dashboard Cite

The pathophysiology of the severe course of COVID-19 is multifactorial and not entirely elucidated. However, it is well known that the hyperinflammatory response and cytokine storm are paramount events leading to further complications. In this paper, we investigated the vascular response in the pathophysiology of severe COVID-19 and aimed to identify novel biomarkers predictive of ICU admission. The study group consisted of 210 patients diagnosed with COVID-19 (age range: 18–93; mean ± SD: 57.78 ± 14.16), while the control group consisted of 80 healthy individuals. We assessed the plasma concentrations of various vascular factors using the Luminex technique. Then, we isolated RNA from blood mononuclear cells and performed a bioinformatics analysis investigating various processes related to vascular response, inflammation and angiogenesis. Our results confirmed that severe COVID-19 is associated with vWF/ADAMTS 13 imbalance. High plasma concentrations of VEGFR and low DPP-IV may be potential predictors of ICU admission. SARS-CoV-2 infection impairs angiogenesis, hinders the generation of nitric oxide, and thus impedes vasodilation. The hypercoagulable state develops mainly in the early stages of the disease, which may contribute to the well-established complications of COVID-19.

show abstract

Section: Discussionmentioning

confidence: 99%