Adverse effect of prematurely elevated progesterone in in vitro fertilization cycles: a literature review

Evans, M. Blake; Healy, M.W.; DeCherney, Alan H.; Hill, Micah J.

doi:10.1093/biolre/ioy082

Cited by 14 publications

(9 citation statements)

References 56 publications

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“…The authors of another recent study (Evans et al, 2018) found that in cycles affected by prematurely elevated P4 levels, vitrification of all embryos and performing a subsequent frozen embryo transfer yielded higher pregnancy rates. This was attributed to the detrimental effects of elevated P4 on the endometrium, resulting in endometrium-embryo asynchrony and implantation failure in fresh cycles.…”

Section: Discussionmentioning

confidence: 99%

Serum progesterone on the day of human chorionic gonadotropin (hCG) trigger as a predictor of in-vitro fertilization (IVF) outcome – a retrospective analysis of seven years

Yadav¹,

Noor²,

Mahey³

et al. 2022

JBRA

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Objective: To investigate the relationship between progesterone (P4) levels on the day of hCG trigger and IVF outcomes.Methods: This is a retrospective analysis of IVF cycles from January-2013 to December-2019 from a single center. Women (21-39 years) submitted to IVF treatment for various infertility factors were included, while donor oocyte cycles and cancelled cycles were excluded from the study. The primary outcome measure was live birth rate.Results: A total of 2149 cycles were analyzed. Of these, 223 (10.38%) were in the low P4 group (<0.5 ng/ml), 1163 (54.12%) in the normal P4 group (0.5-1.5 ng/ml), and 763 (35.50%) in the high P4 group (>1.5ng/ml). The groups were comparable with respect to age, factor of infertility and baseline AMH. The antagonist protocol was significantly more prescribed to the high P4 group (p<0.001). Live birth rates were 14.4%, 21.6%, and 21% (p<0.001), respectively, in three groups. Univariate analysis found that total cetrotide dose, total number of retrieved and fertilized oocytes, total number of embryos formed, transferred, and vitrified, and P4 on the day of hCG (p<0.001) were statistically significant after adjusting for age and BMI. In multivariate logistic regression after adjusting for age and BMI, only high P4 (aOR:0.60; p<0.001), total cetrotide dose (aOR: 0.82; p<0.001), and total utilizable embryos (aOR:1.11; p=0.029) were statistically significant.Conclusions: Having an elevated serum progesterone level on the day of hCG trigger was associated with lower pregnancy rates, but this is still not a robust marker to predict live births. More good quality evidence is needed.

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Section: Discussionmentioning

confidence: 99%

Serum progesterone on the day of human chorionic gonadotropin (hCG) trigger as a predictor of in-vitro fertilization (IVF) outcome – a retrospective analysis of seven years

Yadav¹,

Noor²,

Mahey³

et al. 2022

JBRA

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“…In particular, when serum P4 levels were > 1.75 ng/mL, the rates of GQE at the cleavage stage were significantly reduced. Some analyses have indicated that there is a significant association with a decreased probability of pregnancy during IVF cycles with detrimental endometrial receptivity under a serum P4 threshold > 1.5 ng/mL [ 17 , 18 , 19 ]. However, the clinical criteria for increased P4 levels are highly dependent on individual clinics [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Elevated Progesterone Levels on the Day of hCG on the Quality of Oocyte and Embryo

Woo

Kwon

Choi

et al. 2022

JCM

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This study is designed to investigate the effects of increased progesterone (P4) levels on the quality of retrieved oocytes and embryos during IVF. This retrospective analysis included 982 all-freezing in vitro fertilization (IVF) cycles (conducted between November 2019 and June 2020 at CHA Fertility Center Bundang, South Korea) in which serum P4 levels were measured on the day of human chorionic gonadotropin (hCG) administration. Our study revealed that the serum P4 levels on the day of hCG administration are strongly associated with the rates of oocyte maturation, displaying a positive correlation in patients with serum P4 < 2.25 ng/mL (p = 0.025). Moreover, patients with serum P4 < 1.25 ng/mL showed relatively low fertilization rates (p = 0.037), and the rates of good embryo retrieval were significantly increased with the serum P4 level < 1.5 ng/mL (p = 0.001). Interestingly, serum P4 level on the day of hCG administration affects the rate of good-quality embryo development, especially at the cleavage stage, and is associated with the status of ovarian responses. Our current study suggests that serum P4 level on the day of hCG administration negatively affects the rates of oocyte maturation, fertilization, and the development of good embryos.

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“…This phenomenon is associated with the incidence of premature luteinization. 11,12 Premature luteinization is a term used to refer to a premature LH surge (LH surge), with serum progesterone levels being used as an indication of premature luteinization in various studies. 11,12…”

Section: Discussionmentioning

confidence: 99%

“…4,5 These three factors will be influenced by various characteristics of the patient, such as genetics, age, body mass index, and other comorbidities. 6 Ovarian reserve and the sensitivity of the follicular response to growth after COH are factors that strongly influence the oocyte maturation rate, and this condition can be reflected in the reproductive hormones levels of each participant in the ART program. This study aimed to determine which factors associated with oocyte maturation rate on ART participants.…”

Section: Introductionmentioning

confidence: 99%

Estradiol on Day Seven is a Good Predictor for Oocyte Maturation Rate in In Vitro Fertilization Program

Hestiantoro

Putri

Gunardi

et al. 2022

Indones J Obstet Gynecol

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Abstract Objective: to determine which factors influence the rate of oocyte maturation in In Vitro Fertilization (IVF) program. Methods: A retrospective cohort study was conducted using secondary data from IVF participants at the Yasmin Fertility Clinic, Dr. RSUP. Cipto Mangunkusumo, Jakarta, Indonesia during the period January 2019 to December 2020, as recorded in the InaRepromed archive. The variables analyzed were age, body mass index, and hormone levels on day 1, day 7, and day hCG, with oocyte maturation rate as the main outcome. Correlation test was performed between several variables and the level of oocyte maturation rate and followed by multivariate analysis to assess the factors that were closely related to oocyte maturation rate. Results: Data from 52 subjects were collected for the study. Positive correlation was observed between oocyte maturation rate and estradiol on day 7 (r = 0.229), while negative correlation was observed between oocyte maturation rate and progesterone/estradiol ratio on day 7 (r = -0.289) and luteinizing hormone on day 1 (r = -0.265). Multivariate analysis revealed that higher estradiol on day-7 was associated with better oocyte maturation rate (p = 0.047). Conclusion: Higher estradiol level on day 7 was associated with better oocyte maturation rate in IVF. Keywords: Assisted reproductive technology (ART), estradiol, in vitro fertilization (IVF), progesterone. Abstrak Tujuan: untuk menentukan faktor-faktor yang mempengaruhi tingkat pematangan oosit dalam program Fertilisasi InVitro (FIV). Metode: Desain penelitian adalah kohort retrospektif, menggunakan data sekunder peserta bayi tabung Klinik Fertilitas Yasmin, RSUP Dr. Cipto Mangunkusumo, Jakarta, Indonesia selama periode Januari 2019 hingga Desember 2020, yang tercatat di dalam arsip InaRepromed. Variabel yang dianalisis adalah umur, indeks massa tubuh, dan kadar hormon pada hari ke-1, hari ke-7, dan hari ke-hCG, dengan tingkat maturasi oosit sebagai luaran utama. Dilakukan analisis korelasi antara beberapa variabel dengan tingkat maturasi oosit, dan dilanjutkan dengan analisis multivariat untuk menilai faktor-faktor yang berhubungan kuat dengan tingkat maturasi oosit. Hasil: Data dari 52 subjek dikumpulkan untuk penelitian ini. Dijumpai korelasi positif antara tingkat maturasi oosit dan estradiol pada hari ke 7 (r = 0,229), sedangkan korelasi negatif diamati pula antara tingkat maturasi oosit dan rasio progesteron/estradiol pada hari ke 7 (r = -0,289) dan hormon luteinisasi pada hari 1 (r = -0,265). Analisis multivariat mengungkapkan bahwa estradiol yang lebih tinggi pada hari ke-7 dikaitkan dengan tingkat maturasi oosit yang lebih baik (p = 0,047). Kesimpulan: Kadar estradiol yang lebih tinggi pada hari ke 7 dikaitkan dengan tingkat pematangan oosit yang lebih baik pada program FIV. Kata kunci : Teknologi reproduksi berbantu (TRB), estradiol, fertilisasi in vitro (IVF), progesteron.

show abstract

Adverse effect of prematurely elevated progesterone in in vitro fertilization cycles: a literature review

Cited by 14 publications

References 56 publications

Serum progesterone on the day of human chorionic gonadotropin (hCG) trigger as a predictor of in-vitro fertilization (IVF) outcome – a retrospective analysis of seven years

Serum progesterone on the day of human chorionic gonadotropin (hCG) trigger as a predictor of in-vitro fertilization (IVF) outcome – a retrospective analysis of seven years

Effects of Elevated Progesterone Levels on the Day of hCG on the Quality of Oocyte and Embryo

Estradiol on Day Seven is a Good Predictor for Oocyte Maturation Rate in In Vitro Fertilization Program

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