Adverse Effect of Chlorhexidine and the Development of Resistant Strains, of Bacteria

Abstract

The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in man;

The inhibitory effects on the formation of dental plaque in children using a low concentration of chlorhexidine for a prolonged period.

“…A problem which often arises in a prolonged application of antibiotics is the occurrence of resistant bacterial strains but it was established by ARITA et al, though in vitro [22], that the oral microbiota failed to develop any resistant strains. Throughout the scope of this study no particular resistant strains were observed to increase at any given stage and, from this, it was reasonably assumed that the resistant strains to chlorhexidine digluconate seldom occur in the oral cavity.…”