Adverse effect of amniofetography on fetal thyroid function

Rodesch, Frédéric; Camus, Marguerite; Ermans, A. M.; Dodion, J; Delange, François

doi:10.1016/0002-9378(76)90528-7

Cited by 82 publications

(34 citation statements)

References 3 publications

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“…Recent studies showed normal thyroid functions in the infants of mothers who received iodide contrast during pregnancy (25,26). Amniofetography with iodine containing contrast also Transl Pediatr 17;6(4):349-358 tp.amegroups.com induces transient CH (27).…”

Section: Fetal Iodine Exposurementioning

confidence: 99%

Transient hypothyroidism in the newborn: to treat or not to treat

Kanike¹,

Davis²,

Shekhawat³

2017

Transl. Pediatr

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Section: Fetal Iodine Exposurementioning

confidence: 99%

Transient hypothyroidism in the newborn: to treat or not to treat

Kanike¹,

Davis²,

Shekhawat³

2017

Transl. Pediatr

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“…Studies in animal models and case reports in humans have shown that iodinated contrast agents can cross the placenta and enter the foetus [22][23][24][25][26][27]. It is postulated that the iodinated contrast that enters the foetal circulation is excreted by the kidneys into the amniotic fluid.…”

Section: Discussionmentioning

confidence: 99%

Effect of antenatal iodinated contrast agent on neonatal thyroid function

Rajaram¹,

Exley²,

Fairlie³

et al. 2012

BJR

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Objective: The aim of this study was to assess the effect on neonatal thyroid function of iodinated contrast media administered for CT pulmonary angiography (CTPA) in babies whose mothers were investigated for suspected pulmonary embolism during pregnancy. Methods: Retrospective review of 115 pregnant patients investigated for suspected pulmonary embolism. The patient cohort consisted of two groups: Group A consisted of 73 pregnant females who received iodinated contrast agent for CTPA, and Group B (control group) consisted of 42 pregnant females who were investigated by perfusion imaging only. The results of the neonatal thyroid function tests for the babies of the mothers in Groups A and B were compared. Results: All of the neonatal thyroid function tests for both groups were normal with no statistical difference between the two groups. Conclusion: No adverse effect on thyroid function was demonstrated in neonates exposed to in utero iodinated contrast media. However, as our study involves a small patient group, the results should be interpreted with caution.

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“…Transient hypothyroidism was observed af ter intrauterine application of contrast agents and after neonatal angiocardiography [1][2][3] and after skin disinfection with iodinecontaining solutions [4][5][6]. In other studies, however, no thyroid dysfunction was found after application of iodine-containing prepa rations in neonates [7][8][9][10], These discrepan-…”

mentioning

confidence: 86%

Iodine in Contrast Agents and Skin Disinfectants Is the Major Cause for Hypothyroidism in Premature Infants during Intensive Care

l’Allemand

Grüters²,

Beyer

et al. 1987

Horm Res

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In 51 sick newborns the influence of two different nonionic, iodine-containing contrast agents, Amipaque® (group 1) and Omnipaque® (group 2) and of long-term treatment with polyvinylpyrrolidone-iodine (PVP-I) (group 3) on thyroid function was studied. In the dose given, freshly dissolved Amipaque® releases roughly 100 µg ‘free’ iodide/kg body weight; this release may be even higher in the solubilized agent Omnipaque® because of increased breakdown. Urinary iodine excretion was elevated in all groups on day 5 after iodine exposure. In group 1 which included 17 term newborns, the median TSH level was normal after 5 days and 2 weeks, only 1 case of transient hypothyrotropinemia was observed; T₄ and T₃ median levels were in the lower range of normal. In groups 2 and 3, which included 8 preterm infants of 15 newborns and 9 preterm infants of 19 newborns, respectively, the median TSH values were elevated and T₄ and T₃ levels were very low. Hypothyroidism was diagnosed in 6 of the 8 preterm and in 1 of the 7 term newborns of group 2. In group 3, 7 of the 9 preterm and 3 of the 10 term newborns reacted with hypothyroidism. Eight preterm and 3 term newborns had to be substituted with thyroxine. The thyroid function of term newborns was less affected by Amipaque® or Omnipaque® than by PVP-I. The data show that preterm infants are very sensitive to an iodine load.

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Adverse effect of amniofetography on fetal thyroid function

Cited by 82 publications

References 3 publications

Transient hypothyroidism in the newborn: to treat or not to treat

Transient hypothyroidism in the newborn: to treat or not to treat

Effect of antenatal iodinated contrast agent on neonatal thyroid function

Iodine in Contrast Agents and Skin Disinfectants Is the Major Cause for Hypothyroidism in Premature Infants during Intensive Care

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