Adverse drug reactions: Two years' experience from a tertiary teaching hospital in Kerala

Palappallil, Dhanya Sasidharan; S, Ramnath; Gangadhar, Reneega

doi:10.5455/njppp.2017.7.1131212122016

Cited by 7 publications

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“…In this study, antibiotics accounted for only 12.7% of total drugs causing the ADR. This finding was different from previous studies where antibiotics were the commonest class of drugs causing ADR [3,14].…”

Section: Discussioncontrasting

confidence: 99%

“…Literature review shows that anatomical and physiological variations in the females alter the pharmacokinetic and pharmacodynamics of the drugs and predispose them to more ADRs [11]. In this study, the skin and appendages were the most commonly affected organ in this study which was supported by several studies [12][13][14]. Alopecia was the most common dermatological ADR reported.…”

Section: Discussionsupporting

confidence: 76%

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Pattern of Suspected Adverse Drug Reactions in a Tertiary Care Hospital – A Cross-Sectional Study

Mohanan

Harichandran

2021

Asian J Pharm Clin Res

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Objective: The objective of the study was to study the pattern of suspected adverse drug reactions (ADRs) in a tertiary care hospital. Methods: This is a cross-sectional study conducted in the Department of Pharmacology of a Tertiary Care Teaching Hospital, Kerala. As part of pharmacovigilance activities, the ADRs were collected in Central Drug Standard Control Organization Suspected ADR reporting form from various departments during a period of 3 months and recorded in Pharmacovigilance register maintained by the pharmacology department. As part of our study, we collected the details such as patient’s initials, age, gender, reporting department of hospital, description of the ADR, duration of the reaction, name of suspected ADRs, and outcome from the Pharmacovigilance register. Descriptive statistics will be used for data analysis by statistical package for the social science for windows 16. Results: Two hundred and twenty-two ADR from 141 patients obtained during a period of 3 months. The maximum ADR reports were in age group more than 50 years of age. The skin and appendages were most affected followed by gastrointestinal tract. Antineoplastic drugs accounted for 59.7% of drug class suspected for ADRs followed by use of more than one drug (14.1%). Among antineoplastic drugs, cyclophosphamide and carboplatin accounted for majority causes of ADR. The antibiotics accounted for 12.7% of all drugs. Among the antibiotics penicillin and cephalosporins caused most of the ADRs. Conclusion: The maximum number of ADR reported in our study was with the use of antineoplastic drugs and most common ADR reported was alopecia.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 76%

Pattern of Suspected Adverse Drug Reactions in a Tertiary Care Hospital – A Cross-Sectional Study

Mohanan

Harichandran

2021

Asian J Pharm Clin Res

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“…Concomitant use of more than one drug and delayed onset ADRs have been mentioned as predictors of severe ADRs in another study. [4]…”

Section: Discussionmentioning

confidence: 99%

Pharmacovigilance of cutaneous adverse drug reactions among patients attending dermatology department at a Tertiary Care Hospital

Sharma

Jayakumar

Palappallil

2019

Indian Dermatol Online J

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Context:Cutaneous adverse drug reactions (CADRs) are the most frequent of all manifestations of drug sensitivity that present with varied and diverse morphology and therefore, awareness about them is essential for diagnosis and prevention. Aims: To evaluate the clinical spectrum, morphology, causality, severity and preventability of cutaneous adverse drug reactions in a tertiary care hospital.Setting and Design:Descriptive study for six months in the Dermatology Department of a tertiary care hospital in Kerala.Methods and Materials:All patients of any gender and age who presented with visible skin lesions and were diagnosed or suspected cases of cutaneous adverse drug reactions were included in the study. All the relevant information was recorded using pre-structured proforma and ADR reporting form.Statistical Analysis:Data were analyzed using descriptive statistics. The quantitative variables were expressed as mean ± standard deviation and qualitative variables as frequencies and percentages. Odds ratio (OR) was calculated to assess the risk factors for severe cutaneous adverse drug reactions using SPSS 16.Results:Total 124 cutaneous adverse drug reactions were reported with mean age 39.22 ± 20.47 years, male:female ratio being 1:1.4. Most common cutaneous adverse drug reaction was maculopapular rash. Antibiotics accounted for maximum cases, of which beta-lactams were the most common. About 55.6% cutaneous adverse drug reactions occurred within 24 hours of drug administration. Mean hospital stay duration was 4.89 ± 6.23 days. Most reactions were either mild or moderate. Risk analysis revealed that concomitant use of more than one drug, delayed onset, oral route, more generalized area of involvement and medications prescribed for CNS indications were risk factors for severe cutaneous adverse drug reactions. All reactions were preventable. Majority got fully recovered. No fatality was observed.Conclusion:Identification and reporting of cutaneous adverse drug reactions reduces their future occurrences and encourages rational prescribing. The study emphasizes on having a deeper understanding of risk factors for serious cutaneous adverse drug reactions that may contribute significantly in improving their outcomes.

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Methotrexate

2017

Reactions Weekly

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Adverse drug reactions: Two years' experience from a tertiary teaching hospital in Kerala

Cited by 7 publications

References 0 publications

Pattern of Suspected Adverse Drug Reactions in a Tertiary Care Hospital – A Cross-Sectional Study

Pattern of Suspected Adverse Drug Reactions in a Tertiary Care Hospital – A Cross-Sectional Study

Pharmacovigilance of cutaneous adverse drug reactions among patients attending dermatology department at a Tertiary Care Hospital

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