Adverse drug reactions monitoring of psychotropic drugs: A tertiary care centre study

Singh, Hemendra; Yacob, Mariya; Sabu, Letty; Mamatha, K

doi:10.5958/2394-2061.2017.00009.x

Cited by 6 publications

(11 citation statements)

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“…Several studies also indicate the same. [11][12][13][14] In our study population, maximum ADRs were observed because of atypical antipsychotics. The prescription pattern also revealed that the majority of patients received antipsychotics across all diagnostic categories.…”

Section: Discussionmentioning

confidence: 71%

“…The overall ADRs observed were weight gain (16.48%; n = 45), followed by constipation (15.38%; n = 42), tremors (12.82%; n = 35), and sedation (10.98%; n = 30), and this coincides with the findings of a number of studies. 5 , 10 , 12 , 14 , 15 A high incidence of weight gain was seen owing to more prescription of atypical antipsychotics, especially long-term therapy with them, as 131 patients (48%) had received psychotropic medications for more than six months. Similar results were reported by Farhat et al 17 and Sengupta et al 18 The exact mechanism of antipsychotic-induced weight gain is unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Similar results have been observed in different studies. 12 25 The explanation for a higher risk in females may be that the ADRs are multi-causal, including gender-related differences in pharmacokinetics, pharmacodynamics, pharmacogenetics, immunological, and hormonal factors, as well as diversity in the use of medications (contraceptives) by women compared with men. 25 The reason for more ADRs being experienced in the younger population may be that there might be objective physiological differences in response to psychotropics.…”

Section: Discussionmentioning

confidence: 99%

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Quantifying and Categorizing ADRs in Psychiatric Residential Long-Stay Patients Utilizing UKU-SERS Scale

Mathew

Varghese

Sajith

2020

Indian Journal of Psychological Medicine

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Background: Psychotropic drugs are essential but not devoid of adverse drug reactions (ADRs), which lead to non-compliance and further failure of therapy, hampering the patient’s quality of life. Methods: A cross-sectional, observational study was carried out in a residential nursing home in Pune, India, from October 2018 to March 2019. Psychiatric inpatients of both genders and all ages receiving psychotropic drugs for at least one month were enrolled. Patients who were not alert or oriented enough to give a detailed history and response to a questionnaire, including dementia patients, and those who were not willing to give informed consent were excluded. The ADRs were categorized, and their management was documented using the Udvalg for Kliniske Unders gelser (UKU) side effect rating scale. ADRs were assessed for causality and severity using the WHO-Uppsala Monitoring Centre (WHO-UMC) causality assessment scale and the Modified Hartwig and Siegel scale. Results: In our study, 115 patients (76.6%) experienced 273 adverse drug events. Atypical antipsychotics accounted for the maximum number of ADRs (54.94%; n = 150). The most common ADRs were weight gain, constipation, and tremors. The majority of ADRs were “mild” and had a “possible” causality relationship. Conclusion: The study demonstrated a high incidence of ADRs, which was primarily managed either by reduction of dose or continued drug use with the treatment of side effects.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Quantifying and Categorizing ADRs in Psychiatric Residential Long-Stay Patients Utilizing UKU-SERS Scale

Mathew

Varghese

Sajith

2020

Indian Journal of Psychological Medicine

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“…Etizolam, Alprazolam. 10 The pharmacovigilance activities in India require to be strengthened due to the scarcity of data available related to ADRs especially with psychotropic drugs. 11 Pharmacovigilance in psychiatry can promote detection of ADRs and alert physicians regarding the probability of such events to promote patient safety there are very few reports of ADR profile of psychotropic drugs so Pharmacovigilance program of India (PvPI) is still in infancy and ADR reporting rates is low and requires more data.…”

Section: Introductionmentioning

confidence: 99%

Monitoring adverse drug reaction of psychopharmacological agents: a pharmacovigilance study in tertiary care centre

Kumar¹,

Khosla²

2018

PPIJ

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Objective: The main purpose of this study was to adverse drug reaction monitoring of psychopharmacological agents. Materials and method: The study was cross sectional and was carried out in Departments of Psychiatry in Chhatrapati Shivaji Subharti Hospital and Pharmacology Department, Subharti Medical College, Meerut the duration of this study was approx 6 months (24 weeks). Institutional ethics committee approval was obtained before the start of the study. Results: A total of 110 patients enrolled in the study, and it occurs 148 adverse events. Among which the male patients were 65 (59%). and female were 45(31%). The most common age group whereas 44.5% were from a higher age group. 40 % patients were in the age group from 36 years up to 55 years. In this study most common adverse effect is found in metabolic syndrome such as these were weight gain 15.45%, change in blood glucose 18.18% and change in cholesterol 9.09%. Antipsychotics were given to 35. % patients, antidepressants to 24.5 %, sedatives and hypnotics were given to 20.9 %, anti epileptic to 10.9%, anti maniac drugs to 5.5% and other drugs 3.0% patients. More patients suffering of 25.45% from anti depressant. This study severity of adverse effects. 70(63.6%) had mild adverse effects where as 40(36.4%) had moderate adverse effects and none had severe adverse effects.38% were definitely preventable, 35% were probably preventable, and 27% were not preventable as per clinical evaluations and application of scale Conclusion: the study results strongly suggests the need for professional healthcare team to focus on assessing and reporting suspect adverse effect to increase the quality of monitoring and managing ADRs. Pharmacovigilance improvement the recognition of ADRs and helps the medical health care professional to have safe practice.

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“…Although elderly generally suffer from ADRs more often [21], in the case of psychotropic drugs a number of studies under naturalistic conditions showed similar percentages of severe ADRs in elderly as in young patients [20,22,23]. On the other hand, an increase of concentration-dose ratios with age is described for various psychotropic drugs, e.g.…”

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confidence: 99%

Treatment of Depression: Are Psychotropic Drugs Overdosed in Women and in the Elderly? Dosages of Psychotropic Drugs by Sex and Age in Clinical Routine

Greil

Bardeci

Bernegger

et al. 2020

Preprint

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Background:Psychotropic drugs show higher concentration-dose ratios in women and in the elderly. Furthermore, women partially exhibit more adverse drug reactions than men. Lower dosages in most psychotropic drugs may be recommended in women and in the elderly. This study describes prescribed dosages of psychotropic drugs in depressive patients across sexes and age groups in clinical routine. Method:In 32’082 inpatients with depressive disorders (data acquired by the European drug safety program AMSP), the influence of sex and age on prescribed dosages are analysed for the 10 most commonly prescribed drugs in our dataset (descending in the frequency of prescription: mirtazapine, venlafaxine, lorazepam, quetiapine, citalopram, escitalopram, olanzapine, duloxetine, zopiclone and sertraline) and additionally zolpidem. Confounding variables for sex differences, such as severity of depression and age distribution are examined. Dose decline in patients over 65 years is calculated. The observed sex and age differences in prescriptions are compared to differences in pharmacokinetic literature.ResultsAmong patients over 65, a statistically significant decrease in dosages for increasing age (between 0.65% and 2.83% every year of age) was observed, except for zopiclone. On the other hand, only slight or no influence of sex in prescribed dosages was found.ConclusionAge definitely influences physicians’ decisions in most drugs, but to a lower extent than pharmacokinetic data suggests. Although lower dosages of psychotropic drugs are appropriate for females according to pharmacokinetic data, they are usually prescribed the same dosage as males. Thus, various psychotropic drugs may be overdosed in women.

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Adverse drug reactions monitoring of psychotropic drugs: A tertiary care centre study

Cited by 6 publications

References 0 publications

Quantifying and Categorizing ADRs in Psychiatric Residential Long-Stay Patients Utilizing UKU-SERS Scale

Quantifying and Categorizing ADRs in Psychiatric Residential Long-Stay Patients Utilizing UKU-SERS Scale

Monitoring adverse drug reaction of psychopharmacological agents: a pharmacovigilance study in tertiary care centre

Treatment of Depression: Are Psychotropic Drugs Overdosed in Women and in the Elderly? Dosages of Psychotropic Drugs by Sex and Age in Clinical Routine

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