Adverse drug reactions linked to Ciwujia injection: a systematic review of 521 cases

Abstract

The relevant information of ADRs for Ciwujia injection was insufficiently reported in included studies. The ADR type distribution between clinical studies and ADR reports was inconsistency. Most of the reported ADRs were mild, and were treated successfully by slowing down the drip velocity or by withdrawing the drug and treating the symptoms. As Ciwujia injection was one of the highest numbers of ADR reports of traditional Chinese medicine injections, high quality ADR monitoring, standardized ADR reporting, and timely analysis risk factors of ADRs are extremely urgent.

A strategy for the detection of quality fluctuation of a Chinese herbal injection based on chemical fingerprinting combined with biological fingerprinting

“…Fig. 3 shows that the number of common peaks decreased to 15 (peak numbers 1,8,9,11,12,15,19,21,22, 25 (S), 28, 29, 30, 31, 33) when compared with six batches of abnormal YZHI samples and 10 batches of normal samples. Fig.…”

“…This has been a problem in the QC of herbal injections because unknown substances have resulted in adverse drug reactions and adverse drug events [13]. These include pyrogenic reactions, anaphylactic reactions, allergic shock, or even death [14,15]. Hence, it has become necessary to establish novel approaches for the QC of herbal injections from a biological viewpoint [16][17][18].…”

Pharmacovigilance practice and risk control of Traditional Chinese Medicine drugs in China: Current status and future perspective

“…Standardized protocols are essential to avoid deterioration, reduction in essential oils content, bacterial, fungal or chemical contaminations. Bad practice resulted in high nicotine levels in Chinese dried mushrooms (Anastassiades and Fernandez-Alba, 2009) and bacterial contamination of Ciwujia injection (Du et al, 2008;Hu et al, 2010).…”

“…Through this network the National ADR Monitoring Center identified a series of drug safety problems, such as the Clindamycin Phosphate Glucose Injection (Xinfu) event (Jing et al, 2007;Du et al, 2008) or the Ciwujia Herbal Injectable event (Du et al, 2008;Hu et al, 2010).…”

Simultaneous Determination of Serotonin, b-Hexosaminidase and Histamine in Allergic Guinea Pigs Caused by Three Herbal Injections

“…However, the basic research on its security is defective, especially the sensitivity of allergy test. Over the past ten years, many severe allergic reactions of herbal injection had been reported in China which made great limits of its usage in the clinic 4,5 . Allergic reaction is the most common adverse reaction of herbal injections 6 .…”