Adverse Drug Reactions in Current Antihypertensive Therapy: a General Practice Survey of 2586 Patients in Norway

Olsen, Harald; Klemetsrud, Trine; Stokke, Hans Petter; Tretli, Steinar; Westheim, Arne

doi:10.1080/080370599438266

Cited by 59 publications

(21 citation statements)

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“…In this study we found that CCBs were the commonest group of drugs prescribed, though beta-blockers and ACE inhibitors were associated with higher incidences of ADRs. Our findings corroborate the results of previous studies which mention beta-blockers as the drug category most often implicated with ADRs[620]. Hence, there is a need to review the status of beta-blockers in management of hypertension.…”

supporting

confidence: 91%

“…As expected, combination therapy was associated with higher number of ADRs as compared to monotherapy. Amlodipine and atenolol combination therapy leads to greater risk of ADRs than the monotherapy as reported earlier[61819]. In this study we found that CCBs were the commonest group of drugs prescribed, though beta-blockers and ACE inhibitors were associated with higher incidences of ADRs.…”

supporting

confidence: 77%

“…Pharmacovigilance studies for monitoring ADRs related to antihypertensive agents have been previously conducted by many workers in different parts of the world[6–8]. Monitoring of ADRs in India is in its infancy[9].…”

mentioning

confidence: 99%

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A pharmacovigilance study of antihypertensive medicines at a South Delhi hospital

et al. 2009

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The aim of the present study was to monitor adverse drug reactions associated with antihypertensive drugs. The study was conducted in medicine out patient department of 150-bed Majeedia Hospital at Hamdard University Campus in New Delhi. The study was conducted by way of one to one patient interview by a registered pharmacist using a questionnaire-based Adverse Drug Reaction Monitoring Form drafted according to the World Health Organisation Monitoring Guidelines. A total of 34 adverse drug reactions were observed in 250 hypertensive patients during the four month study. A high percentage of adverse drug reactions occurred in middle aged and female patients. Of the 34 adverse drug reactions, 18 (52.9%) were mild, 14 (41.2%) moderate and only 2 (5.8%) were classified as severe. Combination therapy was associated with significantly high occurrence (P < 0.05) of adverse drug reactions, with a total of 21 (61.8%) as compared to monotherapy (n=13, 38.2%). Cardiovascular adverse drug reactions constituted a major component, followed by gastrointestinal and respiratory complaints. Beta-blockers were the drug category associated with majority of adverse drug reactions, followed by angiotensin-converting enzyme inhibitors and calcium channel blockers. The above pharmacovigilance study presents the adverse drug reaction profile of antihypertensive medicines prescribed in our University Teaching Hospital. It was concluded that calcium channel blockers were the most frequently prescribed drug category but beta blockers were associated with higher frequency of adverse drug reactions.

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confidence: 91%

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confidence: 77%

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A pharmacovigilance study of antihypertensive medicines at a South Delhi hospital

et al. 2009

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“…12 Consistently, a diet high in dietary pulses (1 2 / 3 servings/day) may offer a strategy to manage prehypertension 39 and mild hypertension 38 when supplementing pharmacological agents. Whereas adverse effects from antihypertensive drugs may be problematic, 40 only a few participants on high dietary pulse diets experienced any discomfort.…”

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Pulses on Blood Pressure: A Systematic Review and Meta-analysis of Controlled Feeding Trials

Jayalath

Souza

Sievenpiper

et al. 2013

American Journal of Hypertension

146

102

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BACKGROUNDCurrent guidelines recommend diet and lifestyle modifications for primary prevention and treatment of hypertension, but do not encourage dietary pulses specifically for lowering blood pressure (BP). To quantify the effect of dietary pulse interventions on BP and provide evidence for their inclusion in dietary guidelines, a systematic review and meta-analysis of controlled feeding trials was conducted.METHODSMEDLINE, EMBASE, Cochrane Library, and CINAHL were each searched from inception through 5 May 2013. Human trials ≥3 weeks that reported data for systolic, diastolic, and/or mean arterial BPs were included. Two reviewers independently extracted data and assessed methodological quality and risk of bias of included studies. Effect estimates were pooled using random effects models, and reported as mean differences (MD) with 95% confidence intervals (CIs). Heterogeneity was assessed (χ2 test) and quantified (I2).RESULTSEight isocaloric trials (n = 554 participants with and without hypertension) were included in the analysis. Dietary pulses, exchanged isocalorically for other foods, significantly lowered systolic (MD = −2.25 mm Hg (95% CI, −4.22 to −0.28), P = 0.03) and mean arterial BP (MD = −0.75 mm Hg (95% CI, −1.44 to −0.06), P = 0.03), and diastolic BP non-significantly (MD = −0.71 mm Hg (95% CI, −1.74 to 0.31), P = 0.17). Heterogeneity was significant for all outcomes.CONCLUSIONSDietary pulses significantly lowered BP in people with and without hypertension. Higher-quality large-scale trials are needed to support these findings.CLINICAL TRIAL REGISTRATIONNCT01594567

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“…Many epidemiological studies on risk factors for ADRs have shown that patients on multiple therapies were more likely to develop ADR as compared to patients on monotherapy [15,19-21]. Multiple therapies need to be discouraged as these enhance the probability of ADRs due to drug–drug interactions .…”

Section: Discussionmentioning

confidence: 99%

Monitoring of adverse drug reactions associated with antihypertensive medicines at a university teaching hospital in New Delhi

et al. 2012

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AimTo monitor the adverse drug reactions (ADRs) caused by antihypertensive medicines prescribed in a university teaching hospital.MethodsThe present work was an open, non-comparative, observational study conducted on hypertensive patients attending the Medicine OPD of Majeedia Hospital, Jamia Hamdard, New Delhi, India by conducting patient interviews and recording the data on ADR monitoring form as recommended by Central Drugs Standard Control Organization (CDSCO), Government of India.ResultsA total of 21 adverse drug reactions were observed in 192 hypertensive patients. Incidence of adverse drug reactions was found to be higher in patients more than 40 years in age, and females experienced more ADRs (n = 14, 7.29%) than males, 7 (3.64%). Combination therapy was associated with more number of adverse drug reactions (66.7%) as against monotherapy (33.3%). Calcium channel blockers were found to be the most frequently associated drugs with adverse drug reactions (n = 7), followed by diuretics (n = 5), and β-blockers (n = 4). Among individual drugs, amlodipine was found to be the commonest drug associated with adverse drug reactions (n = 7), followed by torasemide (n = 3). Adverse drug reactions associated with central nervous system were found to be the most frequent (42.8%) followed by musculo-skeletal complaints (23.8%) and gastro-intestinal disorders (14.3%).ConclusionsThe present pharmacovigilance study represents the adverse drug reaction profile of the antihypertensive medicines prescribed in our university teaching hospital. The above findings would be useful for physicians in rational prescribing. Calcium channel blockers were found to be the most frequently associated drugs with adverse drug reactions.

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Adverse Drug Reactions in Current Antihypertensive Therapy: a General Practice Survey of 2586 Patients in Norway

Cited by 59 publications

References 11 publications

A pharmacovigilance study of antihypertensive medicines at a South Delhi hospital

A pharmacovigilance study of antihypertensive medicines at a South Delhi hospital

Effect of Dietary Pulses on Blood Pressure: A Systematic Review and Meta-analysis of Controlled Feeding Trials

Monitoring of adverse drug reactions associated with antihypertensive medicines at a university teaching hospital in New Delhi

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