Adverse drug reaction reporting by doctors in a developing country: A case study from Ghana

Sabblah, Gt; Akweongo, Patricia; Darko, Delese Mimi; Dodoo, Ano N. O.; Sulley, Abdul M.

doi:10.4314/gmj.v48i4.4

Cited by 35 publications

(66 citation statements)

References 11 publications

(11 reference statements)

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“…More than half of the respondents involved in studies carried out by Chopra et al; Ting et al; Vessal et al [8,15,16] were also aware of the existent of their countries' National Pharmacovigilance Centres which are responsible for collecting ADR reports. The present study is again in concordance with the study conducted in the Greater Accra Region of Ghana whish reported that almost all the respondents (96.4) in the study were knowledgeable about PV [13].…”

Section: Resultssupporting

confidence: 92%

“…A recent study by Sabblah et al [13] in the Greater Accra Region of Ghana to assess the ADR reporting among doctors in the region, reported low levels of ADR reporting by the doctors, although almost all the participant (96.4%) in the study exhibited some level of knowledge and agreed that it is their professional responsibility to report ADRs. This study however did not assess the ADR reporting practices by other healthcare professionals (i.e., Nurses and Pharmacist) but recognized the important roles these other professionals need to play to enhance the attainment of the aims of the pharmacovigilance program in Ghana.…”

Section: Pharmacovigilance In Ghanamentioning

confidence: 81%

See 1 more Smart Citation

Pharmacovigilance Practices: Knowledge and Attitudes among the Healthcare Professionals at the Volta Regional Hospital of Ghana

Amedom¹,

Ba²

2017

J Pharmacovigil

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Section: Resultssupporting

confidence: 92%

Section: Pharmacovigilance In Ghanamentioning

confidence: 81%

Pharmacovigilance Practices: Knowledge and Attitudes among the Healthcare Professionals at the Volta Regional Hospital of Ghana

Amedom¹,

Ba²

2017

J Pharmacovigil

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“…Another concern was that only 12.0% of HCPs knew where the ADR forms were kept ( Table 4). These joint findings again suggest a serious and urgent need for appropriate education and training, from identification to reporting, which should improve spontaneous reporting [19,72,76,[89][90][91]. We have seen the successful implementation of a pharmacist-directed improvement plan to enhance ADR reporting in secondary care in South Africa [52].…”

Section: Discussionmentioning

confidence: 98%

Knowledge, attitudes and practices of health care professionals towards adverse drug reaction reporting in public sector primary health care facilities in a South African district

Haines

Meyer

et al. 2020

Eur J Clin Pharmacol

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Purpose Adverse drug reactions (ADRs) have an appreciable impact on patients' health. Little is known however about ADR reporting in ambulatory care environments especially in low-and middle-income countries. Consequently, our aim was to determine knowledge, attitudes and practices (KAP) among health care professionals (HCPs) towards ADR reporting in primary health care (PHC) facilities in South Africa. The findings will be used to direct future activities. Methods Descriptive, cross-sectional design using quantitative methodology among 8 public sector community health care centres and 40 PHC clinics in the Tshwane Health District, Gauteng Province. A self-administered questionnaire was distributed to 218 HCPs, including all key groups. Results A total of 200 responses were received (91.7%). Although an appropriate attitude towards ADR reporting existed, the actual frequency of ADR reporting was low (16.0%). Of the respondents, 60.5% did not know how to report, where to report or when to report an ADR and 51.5% said the level of their clinical knowledge made it difficult to decide whether or not an ADR had occurred. Over 97.5% stated they should be reporting ADRs with 89% feeling that ADR reporting is a professional obligation and over 70% that ADR reporting should be compulsory. When results were combined, the overall mean score in terms of positive or preferred practices for ADR reporting was 24.6% with pharmacists having the highest scores. Conclusion Under-reporting of ADRs with gaps in KAP was evident. There is a serious and urgent need for education and training of HCPs on ADR reporting in South Africa.

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“…However, as in most SSA countries, the PV system based on spontaneous reporting by health professionals in Burkinabe healthcare settings has not yet reached an appropriate performance level, as the reporting rates are still very low. 10,11 In 2015, only 72 reports were referenced in VigiBase TM (the WHO global individual case safety reports database). 12 In SSA countries in general and Burkina Faso in particular, the factors that could explain such low spontaneous reporting are numerous and complex.…”

Section: Introductionmentioning

confidence: 99%

“…Some authors have mentioned important health system obstacles to PV growth in Africa, including weak overall national health infrastructure and systems, poor understanding of PV, lack of PV in the formal curriculum of health professionals' training and low interest by healthcare professionals. 10,[13][14][15][16] Over the past decade, Burkina Faso has experienced a large-scale deployment of new essential drugs, especially artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated malaria. 17 Although ACTs have been used successfully in Southeast Asia 18 and other SSA countries, [19][20][21][22][23] where they appear to be safe and well-tolerated, there is relatively limited experience with these medicines in Burkina Faso, where malaria transmission intensity is substantially higher.…”

Section: Introductionmentioning

confidence: 99%

<p>Optimal Approach and Strategies to Strengthen Pharmacovigilance in Sub-Saharan Africa: A Cohort Study of Patients Treated with First-Line Artemisinin-Based Combination Therapies in the Nanoro Health and Demographic Surveillance System, Burkina Faso</p>

Rouamba¹,

Sondo²,

Derra³

et al. 2020

DDDT

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Background and purpose: Resource-limited countries face challenges in setting up effective pharmacovigilance systems. This study aimed to monitor the occurrence of adverse events (AEs) after the use of artemisinin-based combination therapies (ACTs), identify potential drivers of reporting suspected adverse drug reactions (ADRs) and monitor AEs among women who were inadvertently exposed to ACTs in the first trimester of pregnancy. Patients and methods: We conducted a prospective observational study from May 2010 to July 2012 in Nanoro Health and Demographic Surveillance System (HDSS), Burkina Faso. The HDSS area was divided into active and passive surveillance areas to monitor AEs among patients (regardless of age or sex) who received a first-line ACT (artemetherlumefantrine or artesunate-amodiaquine). In the active surveillance area, patients were followed up for 28 days, while in the passive surveillance area, patients were encouraged to return voluntarily to the health facility to report any occurrence of AEs until day 28 after drug intake. We assessed the crude incidence rates of AEs in both cohorts and performed Cox regression with mixed random effects to identify potential drivers of ADR occurrence. Results: In total, 3170 participants were included in the study. Of these, 40.3% had reported at least one AE, with 39.6% and 44.4% from active and passive surveillance groups, respectively. The types of ADRs were similar in both groups. The most frequent reported ADRs were anorexia, weakness, cough, dizziness and pruritus. One case of abortion and eight cases of death were reported, but none of them was related to the ACT. The variance in random factors showed a high variability of ADR occurrence between patients in both groups, whereas variability between health facilities was low in the active surveillance group and high in passive surveillance group. Taking more than two concomitant medications was associated with high hazard in ADR occurrence, whereas the rainy season was associated with low hazard. Conclusion: This study showed that both passive and active surveillance approaches were useful tools. The HDSS allowed us to capture a few cases of exposure during the first trimester of pregnancy. The passive surveillance approach, which is more likely to be implemented by malaria control programs, seems to be more relevant in the Sub-Saharan African context.

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Adverse drug reaction reporting by doctors in a developing country: A case study from Ghana

Cited by 35 publications

References 11 publications

Pharmacovigilance Practices: Knowledge and Attitudes among the Healthcare Professionals at the Volta Regional Hospital of Ghana

Pharmacovigilance Practices: Knowledge and Attitudes among the Healthcare Professionals at the Volta Regional Hospital of Ghana

Knowledge, attitudes and practices of health care professionals towards adverse drug reaction reporting in public sector primary health care facilities in a South African district

<p>Optimal Approach and Strategies to Strengthen Pharmacovigilance in Sub-Saharan Africa: A Cohort Study of Patients Treated with First-Line Artemisinin-Based Combination Therapies in the Nanoro Health and Demographic Surveillance System, Burkina Faso</p>

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