Adverse Drug Reaction Profile in Patients on Anti-tubercular Treatment Alone and in Combination with Highly Active Antiretroviral Therapy

Sadiq, Shamiya; Khajuria, Vijay; Tandon, Vishal R; Mahajan, Annil; Singh, Jang Bahadur

doi:10.7860/jcdr/2015/13452.6652

Cited by 19 publications

(17 citation statements)

References 17 publications

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“…Patients co-infected with HIV had 3 times more risk than patients without HIV. Similar results were seen in a study by sadiq s et al 27 and fellay J et al 28 showed that concomitant HAART and ATT results in more ADRs. Most of the ADRs in patients with HIV were occurred within a year.…”

Section: Discussionsupporting

confidence: 88%

“…Most of the ADRs 215(69.8%) were having probable relationship with the suspected drugs followed by possible 93(30.19%) which is dissimilar with the studies where most of the ADRs were having possible relationship with suspected drugs. 27,40 Isoniazid was topped the list of anti-tubercular drugs causing ADRs (32.47%) followed by pyrazinamide (27.59%), rifampicin (24.36%), ethambutol (11.36%) and streptomycin (44.22%). 41 INH was mainly responsible for causing Tingling and numbness (11.03%).…”

Section: Discussionmentioning

confidence: 99%

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Assessment of Adverse Drug Reactions in Tuberculosis Patients of South India

Prudhivi¹,

Challa²,

Mv³

et al. 2019

Int. Res. J. Pharm.

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Back ground: Tuberculosis (TB) has become one of the biggest public health challenges in India currently. India is one of the six countries accounted for 60% of the new cases in 2015. Objective: To monitor ADRs and report the occurrence of ADRs, their extent and severity with first line drugs. Materials and methods: The study was a prospective observational, hospital based case control study conducted in Govt. Infectious disease hospital, Guntur, India. The incidence of adverse drug reactions were identified and causality, severity were also analyzed. Results: The record of 308 ADRs was reported among 182(45.5%) patients with ADR occurrence of 1.69 per patient. Of the participants, 264(66%) were male. Maximum number of ADRs were seen in retreatment cases which was proved statistically (P=0.0027). There was a strong significant difference between HIV infected (OR= 3.69, 95% CI= 1.31-2.91; P < 0.0001) and HIV uninfected in occurrence of ADRs. Significant difference was found in total number of ADRs in Cat-I and Cat-II patients. Among 308 reported ADRs, tingling and numbness 34(11.04%) and anorexia 34(11.04%) were the most common ADRs reported. Maximum ADR events were mild 143(46.4%) followed by moderate 131(42.5%) and severe 34(11.0%). The most offending drug for causing ADRs is Isoniazid (32.47%), followed by Pyrazinamide (27.59), Rifampicin (24.36), Ethambutol (11.36) and Streptomycin (11.36%). Conclusion: This research creates the importance of close monitoring of patients who were at higher risk of getting ADRs by health care team and necessary steps should be taken in selecting the right drug regimen.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Assessment of Adverse Drug Reactions in Tuberculosis Patients of South India

Prudhivi¹,

Challa²,

Mv³

et al. 2019

Int. Res. J. Pharm.

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“…35 However, a course of anti-TB drugs usually lasts >6 months, 36 and there can be adverse drug reactions, the most common of which is upper abdominal pain. 37 In recent years, many studies on multidrug-resistant M. tuberculosis have reported the challenges for anti-TB drug therapies. 38 Further research is required to develop new treatment protocols.…”

Section: Discussionmentioning

confidence: 99%

Clinical and pathologic analyses of tuberculosis in the oral cavity: report of 11 cases

Yong

Liu

et al. 2018

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…These findings were same as observed in a study done by Sadiq et al in patients on antiretroviral with concomitant antitubercular therapy. 18 Agu et al, found 50% of ADRs were reported by patients who were taking cotrimoxazole concomitantly with antiretroviral drugs (ARVs).…”

Section: Frequencymentioning

confidence: 99%

A retrospective study to evaluate the pattern of spontaneously reported antiretroviral induced adverse drug reactions in a tertiary care hospital

Patil

Pawar

2018

Int J Basic Clin Pharmacol

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Background: To evaluate the adverse effect profile of spontaneously reported cases of adverse drug reactions due to antiretroviral (ART) drugs in a tertiary care teaching hospital. Methods: A descriptive retrospective study of pattern of ART induced adverse drug reactions (ADRs) spontaneously reported to the Pharmacology department at a tertiary care hospital from January 2011 to December 2016. The details of suspected ADRs including drugs involved, treatment given for ADRs, and the outcome were also documented. These ADRs were analyzed for causality (WHO scale), severity (Hartwig et al. scale), seriousness (ICH E 2A guidelines), preventability (Schumock and Thornton scale) and type based on Edwards and Aronson classification system. Results: Of the 75 cases of ART induced ADRs, reactions were slightly more common in males (52%) and had median age and duration of ART as 36 years and 109 days respectively. Drug induced anemia was the most common presentation followed by cutaneous ADR and zidovudine being the commonest offender. Severity was moderate in 85.3% and causality was probable in 16% and possible in 84% cases. The type reaction was augmented type in 41.3% and not preventable in 76%. Conclusions: Zidovudine is the commonest drug implicated in causing anemia amongst the antiretrovirals. Spontaneous reporting method for antiretroviral pharmacovigilance is insufficient. Targeted spontaneous reporting or cohort event monitoring need to be studied for antiretroviral pharmacovigilance.

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Adverse Drug Reaction Profile in Patients on Anti-tubercular Treatment Alone and in Combination with Highly Active Antiretroviral Therapy

Cited by 19 publications

References 17 publications

Assessment of Adverse Drug Reactions in Tuberculosis Patients of South India

Assessment of Adverse Drug Reactions in Tuberculosis Patients of South India

Clinical and pathologic analyses of tuberculosis in the oral cavity: report of 11 cases

A retrospective study to evaluate the pattern of spontaneously reported antiretroviral induced adverse drug reactions in a tertiary care hospital

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