Adverse drug reaction and concepts of drug safety in Ayurveda: An overview

Ajanal, Manjunath; Nayak, Shradda U; Buduru, Sreenivasa Prasad; Kadam, Avinash

doi:10.1016/j.jyp.2013.10.001

Cited by 18 publications

(13 citation statements)

References 14 publications

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“…Although, Ayurvedic literature has described the eventuality and reasons for drug reactions along with preventive measures, lack of documentation and thereby underreporting of these events pose a major setback. 5 In this study, we found that 5.5 % of all patients admitted with CADR during a ten year period, had polyherbal formulations implicated as a cause. Other studies and case reports have also implicated polyherbal agents as a cause for CADR.…”

Section: Discussionmentioning

confidence: 64%

Cutaneous Adverse Drug Reactions to Polyherbal Formulations - A Retrospective Study

Nair¹,

Varghese²

2019

jemds

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BACKGROUND Although considered natural, herbal therapies can cause allergic reactions and even potentially dangerous side effects. In this article, we address cases of cutaneous adverse drug reactions (CADR) which are possibly related to polyherbal formulations (PHF). METHODS A retrospective study of ten years was carried out where the case sheets of patients admitted in dermatology ward of a tertiary care centre with cutaneous drug reactions were reviewed. Cases with clinical diagnosis of CADR along with history of intake of PHF were analysed. Demographic data, clinical type of drug reaction, drug history and blood investigations were recorded. Naranjo score was done to determine causality. RESULTS 28 out of 506 patients (5.53%) where diagnosed with CADR possibly due to PHF (10 had maculopapular exanthema, 7 had exfoliative dermatitis, 4 cases had TEN, 2 had SJS, 2 had urticaria, and one patient each had DHS, angioedema, and fixed drug eruptions. Naranjo score of 5-6 implied 'possible' causality. Most were in the 30-40 years age group. Female to male ratio was 1.15:1. The commonest systemic association included hepatic involvement followed by renal involvement. All patients were treated with the withdrawal of the culprit drug and administration of systemic steroids and supportive measures. One patient with extensive TEN expired, thus giving a mortality rate of 3.4%. CONCLUSIONS PHF have an untapped potential that should be utilised. However, these drugs need to be scrutinised in the same way as any modern drug, i.e., via randomised controlled clinical trials.

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Section: Discussionmentioning

confidence: 64%

Cutaneous Adverse Drug Reactions to Polyherbal Formulations - A Retrospective Study

Nair¹,

Varghese²

2019

jemds

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“…[22] Therefore, it is vital to restrict oxidative injury to tissues and therefore suppress progression of the disease by supplying antioxidants as nutraceuticals. [23,24] The concept of getting information to support reverse pharmacology is certainly valuable to human health based on the molecular mechanism of action of the compound.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Effect of Aqueous Extract of Mucuna Pruriens (Linn) by DPPH Assay- An in-Vitro Study

Lakshmikandhan¹,

Ravichandar²

2018

jemds

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BACKGROUND In human, oxidative stress has been proposed in the pathogenesis of cardiovascular diseases, neurodegenerative disorders like Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, male and female infertility etc. Objective-The present study was carried out to determine the antioxidant potential of Mucuna pruriens using DPPH assay. MATERIALS AND METHODS The seeds of M. pruriens were powdered and aqueous extract was prepared. DPPH (1, 1-diphenyl-2-picrylhydrazyl) is a stable free radical. The unpaired electron delocalises over the molecule entirely and the molecules will not undergo dimerisation similar to majority of free radicals. This process resulted in formation of deep purple colour, characterised by an absorption band in ethanol solution. The absorbance of all samples was read at 517 nm using UV visible spectrophotometer. Antioxidant activity was calculated. Each step was carried out in triplicate and the average values were entered. The experimental results were expressed as mean ± SD of three parallel measurements. IC50 (minimum inhibitory concentration) values were calculated graphically. RESULTS The DPPH scavenging activity of aqueous extract of Mucuna pruriens was recorded in terms of percentage inhibition. The results obtained were comparable to the standard BHT (Butylated Hydroxytoluene) in a dose dependent manner. Higher percentage scavenging indicates greater antioxidant potential; 1000 micrograms of AEMP shows greatest scavenging activity. CONCLUSION When there is an excessive generation of free radicals, it can result into oxidative stress which gets accumulated during the life span which has been contributed in long-term ailments, therefore it is vital to restrict oxidative injury to tissues and suppress progression of the disease by supplying antioxidants as nutraceuticals. The current study concludes that the aqueous extract of seeds of Mucuna pruriens demonstrated considerable antioxidant activity.

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“…We could not even possibly touch the tip of the iceberg of promises those remained hidden in this ancient science with revelations of this primary reports suggestive of scientific foundation flowing underneath the "clinic to laboratory" or reverse-pharmacology [9] based healing practices under the name of Ayurveda, usually met with scepticism by scientific materialists [13,14]. If we could make ourselves valiant enough to research beyond our comfort zone and begin analyzing and justifying the actions and promises of Ayurveda under the strictest monitoring of current science, we might soon be able to detect certain diseases, even at a very early stage, which is unrecognizable in current diagnostic practices.…”

Section: Discussionmentioning

confidence: 99%

“…So, the path of unification of personalized medicine and Ayurveda can be found in the fundamental principles. Like personalized medicine, Ayurveda is not a 'one-size-fit-all' system and its regimens are tailored to each individual's unique body constitution [12,13]. The focus of Ayurveda is on both patient and disease.…”

Section: Introductionmentioning

confidence: 99%

Genesis of Personalized Medicine: Relevance of Ayurveda in the Present Millennium

Chakraborty¹,

Chakraborty²

2017

J Mol Genet Med

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Deciphering human genome has ushered modern bio-medical science towards a future hope of revitalizing current symptomatic or prophylactic treatment methods into personalized and predictive medicine depending upon an individual's genetic makeup. Genetic variations related to a person's response towards drugs, differential susceptibility to disease and reciprocity of phenotypic attributes related to environment, ethno-racial origin and diseases to genotypes have not been meticulously apprehended yet. Ayurveda, an age-old health science resonated unequivocally with ancient system of classifying a person on the basis of "Prakriti" or unchangeable constitution type might be an advantageous inclination towards personalized medicine, bearing testable molecular and genetic correlates. Several genomic and metabolomic studies augmented the possibilities of yet undisclosed molecular and genetic basis of Ayurveda, which could further be integrated or complemented to current medical diagnosis and treatment. Further deep dive into the extremes of utilizable science and technology of this holistic practice remained quintessential for better enlightenment of future bio-medical science to fight all fiends of ailments.

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Adverse drug reaction and concepts of drug safety in Ayurveda: An overview

Cited by 18 publications

References 14 publications

Cutaneous Adverse Drug Reactions to Polyherbal Formulations - A Retrospective Study

Cutaneous Adverse Drug Reactions to Polyherbal Formulations - A Retrospective Study

Antioxidant Effect of Aqueous Extract of Mucuna Pruriens (Linn) by DPPH Assay- An in-Vitro Study

Genesis of Personalized Medicine: Relevance of Ayurveda in the Present Millennium

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