Adverse Drug Events in Adult Patients Leading to Emergency Department Visits

Sikdar, Khokan C.; Alaghehbandan, Reza; MacDonald, Don; Barrett, Brendan T.; Collins, Kayla; Donnan, Jennifer; Gadag, Veeresh

doi:10.1345/aph.1m416

Cited by 46 publications

(40 citation statements)

References 34 publications

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“…To report accuracy of our attribution of CCHR concordance based on discrete data captured in our EHR, we used weighted estimates of population proportions from in-depth chart review, along with 95% CIs for both weighted and sample statistics for CCHR concordance, where both the total proportion and the variance were weighted by sampling fractions. 28,29 Inter-rater reliability between the consensus review and the blinded reviewer was determined based on percent raw agreement and calculation of the kappa statistic. A sensitivity analysis was performed based on missing data found through chart review, attributing all missing values abnormal and thus making the CT concordant with the CCHR.…”

Section: Discussionmentioning

confidence: 99%

Computed Tomography Use for Adults With Head Injury: Describing Likely Avoidable Emergency Department Imaging Based on the Canadian CT Head Rule

Sharp

Nagaraj

Rippberger

et al. 2017

Academic Emergency Medicine

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Section: Discussionmentioning

confidence: 99%

Computed Tomography Use for Adults With Head Injury: Describing Likely Avoidable Emergency Department Imaging Based on the Canadian CT Head Rule

Sharp

Nagaraj

Rippberger

et al. 2017

Academic Emergency Medicine

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“…Inevitably, as simple extrapolation, this may lead to an inappropriateness of care, and to an increase in the incidence of ADE in women compared to men (Franconi et al 2011a, b;Rademaker 2001). Also the severity of ADE can be more pronounced in females (Krahenbuhl-Melcher et al 2007;Rademaker 2001;Schwartz 2007;Zopf et al 2008): in fact, 60 % of the patients admitted to hospital for ADE are reported to be females (Patel et al 2007;Pirmohamed et al 2004;Sikdar et al 2010). Doserelated ADE are the dominant type in female subjects, particularly those referable to the cardiovascular system (Krahenbuhl-Melcher et al 2007;Rademaker 2001;Zopf et al 2008).…”

Section: Adverse Drug Eventsmentioning

confidence: 99%

Sex and Gender in Adverse Drug Events, Addiction, and Placebo

Franconi

Campesi

Occhioni

et al. 2012

Handbook of Experimental Pharmacology

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Sex-gender-based differences in response to pharmaceutical treatments are still under evaluation but evidence already exists regarding the impact of sex-gender-related differences on drug safety profile, drug abuse/addiction, and placebo effects. For a number of drugs it is well recognized that a sex-gender dimorphic profile in terms of drug adverse effects exists and appears to be more frequent and severe in women than in men. However, it is not well known whether this is due to pharmacodynamic or pharmacokinetic differences. Indeed the optimization of therapy requires that attention is paid to single sex-gender. Numerous pharmacokinetic, pharmacodynamic, and sociocultural differences between women and men in drug abuse have been described. Here we focus on sex-gender differences in alcoholism and nicotine addiction. The relevance of sex and gender differences in addiction appear to be relevant. Specific programs aimed to address addicted women's specific needs (child care, pregnancy, housing, and violence and others) are recommended. Finally, this article discusses the possible effect of sex-gender on placebo response in the light of the more significant recent literature evidencing that studies are urgently required in order to better understand the role of sex-gender on placebo mechanism and its impact on randomized clinical trials outcomes.

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“…Inappropriate use of medicines is a common cause of hospitalisation, particularly among elderly multiple medicine users (Leendertse et al, 2008, Sikdar et al, 2010. To reduce medicine-related problems and the number of preventable hospital admissions, the Australian Government introduced the HMR program, which has -in its first decade of existence -not been used to the projected extent [5] .…”

Section: Discussionmentioning

confidence: 99%

Improving the uptake of the Australian Home Medicines Review (AHMR) through patient segmentation

White

Klinner

Cobelli

2011

International Journal of Pharmaceutical and Healthcare Marketing

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The Australian Home Medicines Review (HMR) Program, aimed at reducing the number of medication-related problems and hospital admissions, has not been used to the extent projected and is little known among eligible consumers.PURPOSE: This paper investigates the problems patients and caregivers have with using medicines appropriately, their desire for assistance with managing medications and their self-perceived need for a Home Medicines Review. DESIGN: A qualitative research study was conducted with 8 semi-structured focus groups including a total of 50 HMR-eligible patients and caregivers. Participants who were purposively sampled represented older males, older females, younger chronically ill patients, patients from Chinese and Arabic backgrounds and the general HMR target group. FINDINGS: According to the types of medicine problems encountered by participants, their level of medicine understanding and their desire for assistance with using medicines, four distinct patient types are identified and explicated: the heedless patient, the aware patient, the scrupulous patient and the self-sufficient patient.PRACTICAL IMPLICATIONS: The uptake of the HMR service can be effectively increased by directto-consumer HMR promotion that is tailored to the behaviors, needs and desires of eligible patients and caregivers. The proposed segmentation model of HMR-eligible consumers addresses these differences and can be used to inform health policy makers regarding a more effective promotion of the HMR service.ORIGINALITY: This is the first study to investigate how the HMR-uptake could be increased from the perspective of eligible patients and their caregivers.

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Adverse Drug Events in Adult Patients Leading to Emergency Department Visits

Abstract: Adult ADE-related ED visits are frequent in Newfoundland and Labrador, and in many cases are preventable. Further efforts are needed to reduce the occurrence of preventable ADEs leading to ED visits.

Cited by 46 publications

References 34 publications

Computed Tomography Use for Adults With Head Injury: Describing Likely Avoidable Emergency Department Imaging Based on the Canadian CT Head Rule

Computed Tomography Use for Adults With Head Injury: Describing Likely Avoidable Emergency Department Imaging Based on the Canadian CT Head Rule

Sex and Gender in Adverse Drug Events, Addiction, and Placebo

Improving the uptake of the Australian Home Medicines Review (AHMR) through patient segmentation

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