Adverse drug effects related to multiday ketamine infusions: multicenter study

Mendelson, Andrew; Kohan, Lynn; Okai, Joseph; Wanees, Mariam; Gonnella, Joseph Charles; Torjman, Marc C.; Viscusi, Eugene R.; Schwenk, Eric S.

doi:10.1136/rapm-2019-101173

Cited by 1 publication

(1 citation statement)

References 6 publications

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“…Furthermore, the guidelines state that liver toxicity most commonly presents as elevated liver transaminases and mostly has been observed in ketamine abusers. However, a subsequent report of 115 patients with rCM and complex regional pain syndrome found that patients were more likely to have developed elevated transaminases during a repeat ketamine infusion than their initial infusion [ 71 ], so caution is warranted even with medically supervised ketamine infusions, and consideration of liver function tests should be given when high-dose or multi-day infusions are planned.…”

Section: Subanesthetic Ketaminementioning

confidence: 99%

Beyond the Raskin Protocol: Ketamine, Lidocaine, and Other Therapies for Refractory Chronic Migraine

Mojica

Schwenk

Lauritsen

et al. 2021

Curr Pain Headache Rep

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Purpose of Review The purpose of this review is to discuss the available evidence and therapeutic considerations for intravenous drug therapy for refractory chronic migraine. Recent Findings In carefully monitored settings, the inpatient administration of intravenous lidocaine and ketamine can be successful in treating refractory chronic migraine. Summary Many patients with refractory chronic migraine have experienced treatment failure with the Raskin protocol. The use of aggressive inpatient infusion therapy consisting of intravenous lidocaine or ketamine, along with other adjunctive medications, has become increasingly common for these patients when all other treatments have failed. There is a clear need for prospective studies in this population comprised of patients who have largely been excluded from other studies.

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Section: Subanesthetic Ketaminementioning

confidence: 99%