Adverse cutaneous drug reactions: A one year survey at a dermatology outpatient clinic of a tertiary care hospital

Chatterjee, Seshadri Sekhar; Ghosh, Arijit; Barbhuiya, Joyashree Nath; Sk, Dey

doi:10.4103/0253-7613.28212

Cited by 77 publications

(139 citation statements)

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“…This result was similar to a Tunisian study but in contrast to many other studies where an bio cs were the common culprits followed by an convulsants. 5,10,12,14,18,20 However unknown medica on made second largest group in a study 17 and it was 14.4%(n=6) in our study. Carbamazepine accounted for 24% SJS/TEN in a study from Malaysia.…”

Section: Discussionmentioning

confidence: 51%

Patterns and Outcomes of Cutaneous Adverse Drug Reactions in a Hospital Based Study

Paudel¹,

Parajuli²,

Pokhrel³

2017

Nepal J Dermatol Venereol & Leprol

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Section: Discussionmentioning

confidence: 51%

Patterns and Outcomes of Cutaneous Adverse Drug Reactions in a Hospital Based Study

Paudel¹,

Parajuli²,

Pokhrel³

2017

Nepal J Dermatol Venereol & Leprol

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“…All of these medications were reported to be associated with urticaria in several previous studies. [7][8][9][10] Antihistamine like Cetrizine causing urticaria was observed in 4 cases in our study. Similar observation was reported by Calista et al…”

Section: Discussionmentioning

confidence: 92%

Prevalence and pattern of adverse cutaneous drug reactions presenting to a tertiary care hospital

Janardhan

Shailendra

2017

Int J Res Dermatol

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Background: An adverse cutaneous drug reaction (ACDR) is defined as an undesirable clinical manifestation resulting from administration of a particular drug. With an ever increasing number of drugs and varied formulations being continuously made available it is important that a close watch on the risks of adverse drug reactions is looked for, to ensure safe use of medicines in the interest of the patient. In the present study our aim is to study the prevalence & pattern of cutaneous adverse drug reactions reported to department of dermatology at MediCiti Institute of Medical Sciences, Hyderabad, India.Methods: All suspected cutaneous adverse drug reactions reported to the department of dermatology at MediCiti Institute of Medical Sciences during the two year period from January 2013 to December 2014 were included in this study. A thorough clinical examination of all these cases & details related to the drug use and clinical manifestations of the cutaneous adverse drug reaction were documented using a structured proforma. Naranjo scale was used to assess causality in all the causes of cutaneous adverse drug reactions.Results: The mean age of the patients was 42 years (age range: 1-64 years). Most of them were in the age group of 30-39 years. The male to female ratio was 1.78:1. The most common type of skin eruptions observed were maculopapular rash (35.55%), urticaria (26.19%) and fixed drug eruption (17.87%). The mean duration between drug intake and appearance of rash was 4 days (range: 1-120 days). Conclusions: The pattern of ACDRs and the drugs causing them in this study were similar to that reported in other studies both in terms of disease burden and clinical pattern. Knowledge of adverse cutaneous drug reactions will help to identify common medications contributing to dermatological reactions, so as to anticipate, prevent and limit their undue consequences.

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“…These observations are in conformity with other studies. 7,9,16,21 Others have noted exanthematous eruption (maculopapular rash) to be the most common type of drug reaction found fixed drug eruptions as the most common drug eruption followed by maculopapular rash and urticaria. 20,22 This variation could be due to different patterns of drug usage and different ethnic group characteristics in different parts of our country.…”

Section: Discussionmentioning

confidence: 99%

“…17 Our results differ from other studies where antiepileptics were the major drug groups responsible for more than 50% cases of maculopapular eruptions. 7,9,21 NSAIDs and antimicrobials were the main culprits in causing urticaria. They alone were responsible for 84 % cases of urticaria.…”

Section: Discussionmentioning

confidence: 99%

A study of adverse cutaneous drug reactions in the department of dermatology of a teaching hospital in Jamnagar, India

Dhanani

Sukhlecha

2017

Int J Basic Clin Pharmacol

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Background: Adverse drug reactions cause significant morbidity and mortality in health care set up. They are responsible for a significant number of hospital admissions. The data for adverse cutaneous drug reactions (ACDRs) is limited our country. Thus, the present study emphasises on the need of an effective adverse drug reaction reporting programme.Methods: A prospective study to assess the ACDRs in Dermatology department was conducted in a teaching hospital of India. Male to female ratio, most common class of drug, individual drugs causing ACDRs, common types of ACDRs were studied. Other parameters like causality assessment, preventability and seriousness of ACDRs were also studied.Results: A majority of the patients (38%) with ACDR were in the age group of 25-44 years followed by 45-64 years (31%). The rate of ACDRs was more in males (54%). The most frequent ACDR reported was maculopapular rash (38%), followed by urticaria (19%) and fixed drug eruptions (12%). Most of the reactions (93%) were bizarre/ unpredictable in nature. Amongst drug groups, antimicrobials (48%) were most frequently associated with ACDRs followed by NSAIDs (30%) and antiepileptics (12%). Most of the reactions (94%) were mild-moderate in nature. Only 9% of ACDRs reported in this study were preventable. Paracetamol was the most common offending drug followed by cotrimoxazole, ibuprofen, amoxicillin, phenytoin in decreasing order. Causality assessment found ACDRs in probable category (68%) using WHO-UMC criteria.Conclusions: It is important to monitor and report adverse drug reactions in order to promote safe and rational use of medicines.

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Adverse cutaneous drug reactions: A one year survey at a dermatology outpatient clinic of a tertiary care hospital

Cited by 77 publications

References 0 publications

Patterns and Outcomes of Cutaneous Adverse Drug Reactions in a Hospital Based Study

Patterns and Outcomes of Cutaneous Adverse Drug Reactions in a Hospital Based Study

Prevalence and pattern of adverse cutaneous drug reactions presenting to a tertiary care hospital

A study of adverse cutaneous drug reactions in the department of dermatology of a teaching hospital in Jamnagar, India

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