Adverse childhood experiences influence the detrimental effect of bipolar disorder and schizophrenia on cortico-limbic grey matter volumes

Poletti, Sara; Vai, Benedetta; Smeraldi, Enrico; Cavallaro, Roberto; Colombo, Cristina; Benedetti, Francesco

doi:10.1016/j.jad.2015.09.049

Cited by 41 publications

(24 citation statements)

References 74 publications

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“…All but one study included subjects who were medicated at the time of scanning, and only a minority of studies focused on first episode patients (Table 1). Cortical gray matter volume loss appears widespread in schizophrenia, but less extensive 29–31 or even absent 32, 33 in BD. It has been suggested as an intermediate phenotype across disease categories, possibly reflecting lifetime psychosis burden, with patients diagnosed with schizophrenia and schizoaffective disorder demonstrating extensive neocortical and subcortical gray matter reductions, and smaller reductions limited to frontotemporal regions in BD.…”

Section: Resultsmentioning

confidence: 99%

“…HC > BD in precuneus, superior parietal and postcentral gyrus. SZ = BD in GM volumeAmann et al 125 201545/45/45 /45P/NPMixedMedicatedWhole brainVBM1.5HC > SZ and SAD in anterior cingulate, insula, temporal lobe, cerebellum; HC = BDRoyer et al 126 201563/31/0/20ChronicMedicatedWhole brain gray matter asymmetryIn house processing3No group differencesPoletti et al 31 2016136/96/0/206ChronicMedicatedWhole brainVBM3HC > SZ in inferior frontal gyrus, thalamus, insula and superior temporal gyrus; HC > BD inferior frontal gyrus; BD > SZ thalamusReavis et al 127 201630/33/0/31NPChronicMedicatedLateral occipital complex and retinotopic visual cortexROI3HC >BD>SZ in retinotopic cortex and lateral occipital complexKnoechel et al 128 201638/32/0/34NPChronicMedicatedWhole brainFree Surfer3HC > BD = SZ in cortical thickness in inferior frontal gyrus, ACC, PCC. HC > SZ in dorsal frontal and temporal areas.…”

Section: Resultsmentioning

confidence: 99%

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Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

et al. 2017

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Since Emil Kraepelin's conceptualization of endogenous psychoses as dementia praecox and manic depression, the separation between primary psychotic disorders and primary affective disorders has been much debated. We conducted a systematic review of case-control studies contrasting magnetic resonance imaging studies in schizophrenia and bipolar disorder. A literature search in PubMed of studies published between January 2005 and December 2016 was conducted, and 50 structural, 29 functional, 7 magnetic resonance spectroscopy, and 8 combined imaging and genetic studies were deemed eligible for systematic review. Structural neuroimaging studies suggest white matter integrity deficits that are consistent across the illnesses, while gray matter reductions appear more widespread in schizophrenia compared to bipolar disorder. Spectroscopy studies in cortical gray matter report evidence of decreased neuronal integrity in both disorders. Functional neuroimaging studies typically report similar functional architecture of brain networks in healthy controls and patients across the psychosis spectrum, but find differential extent of alterations in task related activation and resting state connectivity between illnesses. The very limited imaging-genetic literature suggests a relationship between psychosis risk genes and brain structure, and possible gene by diagnosis interaction effects on functional imaging markers. While the existing literature suggests some shared and some distinct neural markers in schizophrenia and bipolar disorder, it will be imperative to conduct large, well designed, multi-modal neuroimaging studies in medication-naïve first episode patients that will be followed longitudinally over the course of their illness in an effort to advance our understanding of disease mechanisms.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

et al. 2017

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“…The neurobiological and psychological effects of child neglect, abuse, or trauma persist during adulthood, representing fundamental factors influencing people's health status. Adverse childhood experiences (ACE) influence several aspects of psychiatric disorders outcome: (i) they predict antidepressant response; (ii) they influence brain structure and function in depressive, anxious, and psychotic disorders; (iii) they influence the levels of peripheral proinflammatory cytokines; (iv) they worsen mood‐congruent cognitive distortions in depression; (v) they increase the risk of suicide; and (vi) they increase the overall severity of the disorders …”

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confidence: 99%

Multidimensional cognitive impairment in unipolar and bipolar depression and the moderator effect of adverse childhood experiences

Poletti

Aggio

Brioschi

et al. 2017

Psychiatry Clin Neurosci

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“…Bipolar patients with adverse childhood experiences compared to healthy individuals exhibited GMV loss in the bilateral orbitofrontal cortex and the thalamus. 22 Similarly, GMV in the right dorsolateral prefrontal cortex and the right thalamus was smaller in BD patients with childhood traumas than patients without them. 19 In familial pediatric BD, there was a significant negative association between the total hippocampal volume and anxiety scores.…”

Section: Original Articlementioning

confidence: 91%

Cortical Volumetric Correlates of Childhood Trauma, Anxiety, and Impulsivity in Bipolar Disorder

Song¹,

Chon²,

Ryu³

et al. 2020

Psychiatry Investig

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Objective More recently, attention has turned to the linkage between childhood trauma and emotional dysregulation, but the evidence in bipolar disorder (BD) is limited. To determine neurobiological relationships between childhood trauma, current anxiety, and impulsivity, we investigated cortical volumetric correlates of these clinical factors in BD.Methods We studied 36 patients with DSM-5 BD and 29 healthy controls. Childhood trauma, coexisting anxiety, and impulsivity were evaluated with the Korean version-Childhood Trauma Questionnaire (CTQ), the Korean version-Beck Anxiety Inventory (BAI), and the Korean version-Barratt Impulsiveness Scale (BIS). Voxel-based morphometry (VBM) was used to assess gray matter volume (GMV) alterations on the brain magnetic resonance imaging (MRI). Partial correlation analyses were conducted to examine associations between the GMV and each scale in the BD group.Results Childhood trauma, anxiety, and impulsivity were interrelated in BD. BD patients revealed significant inverse correlations between the GMV in the right precentral gyrus and CTQ scores (r=-0.609, p<0.0003); between the GMV in the left middle frontal gyrus and BAI scores (r=-0.363, p=0.044). Moreover, patients showed similar tendency of negative correlations between the GMV in the right precentral gyrus and BIS scores; between the GMV in the left middle frontal gyrus and CTQ scores.Conclusion The present study provides evidence for a neural basis between childhood trauma and affect regulations in BD. The GMV alterations in multiple frontal lobe areas may represent neurobiological markers for anticipating the course of BD.

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Adverse childhood experiences influence the detrimental effect of bipolar disorder and schizophrenia on cortico-limbic grey matter volumes

Cited by 41 publications

References 74 publications

Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

Multidimensional cognitive impairment in unipolar and bipolar depression and the moderator effect of adverse childhood experiences

Cortical Volumetric Correlates of Childhood Trauma, Anxiety, and Impulsivity in Bipolar Disorder

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