Adverse Childhood Experiences and Suicidal Behavior

Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy

“…For example, animals in captivity or separated from their master have been reported to starve to death voluntarily (Preti and Miotto 2005;Ramsden and Wilson 2010) or exhibit self-destructive behaviours (Crawley et al 1985); uncontrolled anxiety provoking situations including isolation, separation and confinement have been reported to result in self-endangering behaviours in primates (Kraemer and Clarke 1990;tiefenbacher et al 2005); monkeys in reared isolation showed higher risk of self-endangered behaviour in adulthood (Crawley et al 1985). this latter finding parallels the impact of childhood abuse or neglect on the risk of suicide in humans (Evans et al 2005;Brodsky and Stanley 2008). However, the degree to which such selfendangering behaviours in animals resemble self-harming behaviour in humans is debatable.…”

Creating Suicide Safety in Schools: A public health suicide prevention program in New York State

“…This continuum starts at the individual level, encompassing a person's biology, psychology, and social history. Risk factors on this level might include things like depression, impulsively aggressive responses to stress, poor coping skills, substance abuse, experiences with death and trauma (Fergusson et al, 2000;Bruffaerts et al, 2010;Brodsky and Biggs, 2013;King et al, 2013;Brent, 2001). Additionally, risk is influenced by a person's family and peer relationships.…”

HPA axis genes may modulate the effect of childhood adversities on decision-making in suicide attempters

“…Among the known vulnerability traits specifically associated with suicidal behavior are a history of childhood abuse (Brodsky and Stanley, 2008), impaired decision-making (Jollant et al, 2005) and a dysregulation of the HPA axis (Coryell and Schlesser, 2001). Moreover, stress-regulatory genes, such as CRHR1, may underlie the increased susceptibility of some individuals towards suicidal behavior (Ben-Efraim et al, 2011, Wasserman et al, 2008, Wasserman et al, 2009).…”