Adverse changes in tendon–muscle physiology and physical function caused by an isolated acute rheumatoid knee effusion: A case study

Matschke, V.; Thom, Jeanette M.; Lemmey, Andrew; Maddison, Peter J.; Jones, Jeremy

doi:10.1002/acr.20493

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…However, in a case report on unilateral inflammatory knee effusion in a patient with newly diagnosed RA [28], we found reduction of PT stiffness initially only in the leg affected by knee joint effusion, but one year later both PTs were affected despite controlled disease activity and maintenance of regular physical activity. Loss of muscle specific force and muscle CSA in the affected leg in the acute stage of knee effusion was also observed.…”

Section: Discussionmentioning

confidence: 67%

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Patellar Tendon Properties and Lower Limb Function in Rheumatoid Arthritis and Ankylosing Spondylitis versus Healthy Controls: A Cross‐Sectional Study

Matschke

Jones

Lemmey

et al. 2013

The Scientific World Journal

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Objective. Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) lead to inflammation in tendons and peritendinous tissues, but effects on biomechanical tendon function are unknown. This study investigated patellar tendon (PT) properties in stable, established RA and AS patients. Methods. We compared 18 RA patients (13 women, 59.0 ± 2.8 years, mean ± SEM) with 18 age- and sex-matched healthy controls (58.2 ± 3.2 years), and 12 AS patients (4 women, 52.9 ± 3.4 years) with 12 matched controls (54.5 ± 4.7 years). Assessments with electromyography, isokinetic dynamometry, and ultrasound included quadriceps muscle force and cross-sectional area (CSA), PT stiffness, and PT CSA. Additionally, measures of physical function and disease activity were performed. Results. PT stiffness and physical function were lower in RA and AS patients compared to healthy controls, without a significant difference in force production. PT CSA was significantly larger leading to reduction in Young's modulus (YM) in AS, but not in RA. Conclusion. The adverse changes in PT properties in RA and AS may contribute to their impaired physical function. AS, but not RA, leads to PT thickening without increasing PT stiffness, suggesting that PT thickening in AS is a disorganised repair process. Longitudinal studies need to investigate the time course of these changes and their response to exercise training.

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Section: Discussionmentioning

confidence: 67%

“…The Modified Health Assessment Questionnaire (MHAQ) [22] and the 36 questions of the Short-Form Health Survey (SF-36) [23] provided information on subjective physical function and health-related quality of life (QoL), respectively. These questionnaires and physical function tests have been used in RA and AS populations before [24–28]. …”

Section: Methodsmentioning

confidence: 99%

Patellar Tendon Properties and Lower Limb Function in Rheumatoid Arthritis and Ankylosing Spondylitis versus Healthy Controls: A Cross‐Sectional Study

Matschke

Jones

Lemmey

et al. 2013

The Scientific World Journal

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Effects of different local cryotherapies on systemic levels of TNF-α, IL-6, and clinical parameters in active rheumatoid arthritis

et al. 2013

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Cryotherapies are frequently used to supplement the rehabilitation of patients with rheumatoid arthritis (RA) owing to their analgesic and anti-inflammatory effects. Forty patients with active RA were recruited and received 10 days of comprehensive therapy with different local cryotherapies. None of the respondents were subjected to biological treatment. They were divided into two groups according to the therapy received: nitrogen vapour at -160 °C (group I) or cold airflow at -30 °C (group II). Levels of tumour necrosis factor α (TNF-α), interleukin 6 (IL-6), disease activity score (DAS28), and functional variables were used to assess the outcomes. After the therapy, both groups exhibited similar improvements. Significant reduction in TNF-α level (nitrogen: p < 0.01; cold air: p < 0.05) and no change in IL-6 were observed. DAS28, the clinical severity of pain, duration of morning stiffness, degree of self-reported fatigue, and health assessment questionnaire (HAQ) scores improved significantly. In addition, the active range of knee extension, time, and the number of steps in the 50-m walk test also clearly got better in both groups. The 10-day comprehensive therapies including different local cryotherapies for the patients with RA cause significant decrease in TNF-α systemic levels, meaningly improve DAS28, HAQ scores, and some functional parameters, but do not change IL-6 levels. However, there were no differences in the effectiveness of either cryotherapy.

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Tight control of disease activity fails to improve body composition or physical function in rheumatoid arthritis patients

et al. 2016

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Despite marked improvements in disease control (most patients achieving or approaching remission), the relative loss of MM and increased adiposity in RA patients compared with matched HCs was similar to that observed pre-T2T. Additionally, performance of objective function tests was unchanged from that reported by our group for pre-T2T RA patients. Thus T2T, even in responsive RA patients, did not attenuate rheumatoid cachexia or improve objectively assessed function.

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Adverse changes in tendon–muscle physiology and physical function caused by an isolated acute rheumatoid knee effusion: A case study

Cited by 4 publications

References 16 publications

Patellar Tendon Properties and Lower Limb Function in Rheumatoid Arthritis and Ankylosing Spondylitis versus Healthy Controls: A Cross‐Sectional Study

Patellar Tendon Properties and Lower Limb Function in Rheumatoid Arthritis and Ankylosing Spondylitis versus Healthy Controls: A Cross‐Sectional Study

Effects of different local cryotherapies on systemic levels of TNF-α, IL-6, and clinical parameters in active rheumatoid arthritis

Tight control of disease activity fails to improve body composition or physical function in rheumatoid arthritis patients

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