Adverse and traumatic exposures, posttraumatic stress disorder, telomere length, and hair cortisol – Exploring associations in a high-risk sample of young adult residential care leavers

Bürgin, David; Clemens, Vera; Varghese, Nimmy; Huber, Mara; Bruttin, Evelyne; Boonmann, Cyril; Unternährer, Eva; O’Donovan, Aoife; Schmid, Marc

doi:10.1016/j.bbih.2022.100524

Cited by 7 publications

(6 citation statements)

References 118 publications

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“…Note to mention that telomeric DNA is highly susceptible to oxidative damage and maternal stress altered the telomere dynamic through oxidative stress [ 15 ]. In addition, earlier studies reported that stress shortens the telomere length [ 15 , 16 , 64 ]. Therefore, we examined the telomere length and the regulatory molecules that maintain the telomere length.…”

Section: Discussionmentioning

confidence: 99%

Maternal stress-induced changes in adolescent and adult offspring: Neurobehavioural improvement and telomere maintenance

Sivasangari,

Sivamaruthi,

Chaiyasut

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Maternal stress-induced changes in adolescent and adult offspring: Neurobehavioural improvement and telomere maintenance

Sivasangari,

Sivamaruthi,

Chaiyasut

et al. 2023

Heliyon

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“…The telomere length was measured by quantitative polymerase chain reaction (qPCR) according to approaches described previously [154][155][156][157]. To determine the telomere length, the T/S ratio (telomere repeat copy number (TELO) to single-copy gene number (SCG), which represents a relative measure of the telomere length, was accessed.…”

Section: Telomere Length Determination By Qpcrmentioning

confidence: 99%

Preservation of an Aging-Associated Mitochondrial Signature in Advanced Human Neuronal Models

Varghese,

Szabo,

Cader

et al. 2024

Preprint

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This study investigated whether induced pluripotent stem cell-derived neurons (iPSCsNs) and directly converted neurons (iNs) generated from the same cells of origin (human fibroblasts) represent aging-related characteristics on mitochondrial levels. There is still uncertainty regarding the potential for rejuvenation or preservation of an aging-associated donor signature in aged iPSCsNs upon transition through pluripotent states, while direct conversion retains the aging-associated mitochondrial impairments. Surprisingly, both aged neuronal models exhibited age-associated donor phenotypes, including decreased ATP, mitochondrial membrane potential, mitochondrial respiration, NAD+/NADH ratio, and increased radical levels and mitochondrial mass. Besides, a fragmented mitochondrial network was observed in both aged neuronal models. However, unlike aged iNs, aged iPSCsNs did not show a metabolic shift towards anaerobic glycolysis to compensate for the energy deficit. Moreover, the mRNA expression profile significantly differed between aged iPSCsNs and aged iNs. Our study indicates that aged iPSCsNs may experience rejuvenation in certain parameters, such as transcriptomics and the aging-associated glycolytic shift. Nevertheless, aged iPSCsNs can be a valuable tool for studying neuronal aging of mitochondrial parameters in vitro alongside aged iNs.

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“…For this purpose, data from the "Long-Term Outcomes of Childhood Adversities and Offending Behavior (LOCO)" project was complemented by measuring sBDNF concentration in blood samples collected from these participants [6,54]. All adolescents have been placed in residential youth care.…”

Section: The Current Studymentioning

confidence: 99%

“…This study investigated a vulnerable population accumulating multiple biological and psychosocial risk factors leading to severe mental health impairment later in life [6,73,74].…”

Section: Clinicalmentioning

confidence: 99%

“…The period between early childhood and adolescence is considered one of the most stress-sensitive phases in human development [2,3]. Children in institutional care accumulate multiple biological and psychosocial risk factors towards developing adverse health outcomes, reduced well-being, and psychopathology in adulthood [4][5][6]. Furthermore, children placed in residential care are likely to experience high levels of childhood adversities and potential traumatic exposures [7].…”

Section: Introductionmentioning

confidence: 99%

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Association of Indicators of Stress, Sleep and Brain-Derived Neurotrophic Factor (BDNF) in a High-risk Sample of Young Adults with Previous Youth Residential Care

Varghese¹,

Bürgin²,

Boonmann³

et al. 2023

Preprint

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BackgroundChildren in institutional care have a high risk to experience childhood adversities (CAs), with consequences for physical and mental well-being. The long-term effects of CAs on the brain, including consequences for neuronal plasticity and sleep, are poorly understood. This study examined the interplay between stress (including CAs), sleep, and brain-derived neurotrophic factor (BDNF), a prominent marker for neuronal plasticity. MethodParticipants (N=131, mean age = 26.33.4 years, 40 females) with residential youth-care history completed questionnaires measuring CAs (Childhood Trauma Questionnaire, CTQ), psychological well-being (World Health Organization-Five Well-Being Index, WHO-5), and sleep disturbances (Pittsburgh Sleep Quality Inventory, PSQI). Hair cortisol and serum BDNF concentration were measured using enzyme-linked immunosorbent assays. The analyses were conducted by using bootstrap regression models. ResultsThere was no association of stress parameters or sleep with BDNF concentration. However, we found a significant association of CAs and well-being with sleep disturbances. Last, we found an association between CAs and BDNF in sleep-healthy but not sleep-disturbed participants.ConclusionOur findings emphasize the importance of sleep quality in the association between stress and BDNF. Still, further studies are warranted using vulnerable groups at-risk to understand long-term effects on mental health and sleep.

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Adverse and traumatic exposures, posttraumatic stress disorder, telomere length, and hair cortisol – Exploring associations in a high-risk sample of young adult residential care leavers

Cited by 7 publications

References 118 publications

Maternal stress-induced changes in adolescent and adult offspring: Neurobehavioural improvement and telomere maintenance

Maternal stress-induced changes in adolescent and adult offspring: Neurobehavioural improvement and telomere maintenance

Preservation of an Aging-Associated Mitochondrial Signature in Advanced Human Neuronal Models

Association of Indicators of Stress, Sleep and Brain-Derived Neurotrophic Factor (BDNF) in a High-risk Sample of Young Adults with Previous Youth Residential Care

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