Adverse airway events during brief nasal inhalations of volatile anaesthetics: the effect of humidity and repeated exposure on incidence in volunteers preselected by response to desflurane*

Wilkes, A. R.; Raj, Nichelle; Hall, Judith Elizabeth

doi:10.1046/j.1365-2044.2003.02965.x

Cited by 9 publications

(9 citation statements)

References 44 publications

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“…Wilkes et al stated that desflurane was the most irritant agent of the upper respiratory tract. [6] Cervin and Lindberg found that NK1 receptors are influenced in airway irritants and atropine does not decrease the early ciliary beat frequency due to desflurane. Use of NK1 antagonists may prevent the elongation of SNTT.…”

Section: Discussionmentioning

confidence: 98%

“…The high standards of the anesthesia machines, the presence of monitors continuously monitoring and analyzing the gas composition and the increased knowledge of pharmacodynamics and pharmacokinetics of inhaled anesthetics has greatly simplified the safe use of low-flow anesthesia. [6] The humidity and heat of anesthetic gases increases greatly in low-flow anesthesia techniques. Low-flow anesthesia, not only improves the environment, but also significantly reduces the consumption of anesthetic gases and volatile agents, thereby providing cost savings and a reduction in operating room and atmospheric pollution.…”

Section: Discussionmentioning

confidence: 99%

“…Thus the physiology of the tracheobronchial environment is better preserved. Although there have been studies of the effect of high-flow desflurane anesthesia on mucociliary clearance, [1,5,6] to the best of our knowledge, there have been no studies of the effect of low-flow desflurane anesthesia. The aim of this study was to evaluate the effect of low-flow desflurane anesthesia on nasal mucociliary clearance.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Low-Flow Desflurane Anesthesia on Mucociliary Clearance

Gamlı¹,

Zengin²,

Ornek³

et al. 2016

Acad. Anesthesiol. Int.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Low-Flow Desflurane Anesthesia on Mucociliary Clearance

Gamlı¹,

Zengin²,

Ornek³

et al. 2016

Acad. Anesthesiol. Int.

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“…The effects of anesthetic gases on mucociliary clearance have also been investigated in studies performed before and after the patients received anesthesia (10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Assessment of nasal mucociliary clearance in anesthetists

Horasanlı¹,

Acar²,

Muslu³

et al. 2015

Turk J Med Sci

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IntroductionWaste anesthetic gases can escape into the air of operating theaters from various components of the anesthesia delivery system during the clinical administration of inhaled anesthetics. In spite of advanced scavenging systems, the amount of waste gases in operating theaters depends on multiple factors, such as the type of anesthesia equipment (closed/open system), the anesthesia techniques (high/low flow rate, use of face masks or laryngeal mask airways, use of uncuffed tracheal tubes), and the methods of anesthetic induction (1-3). Recently, there have been important improvements in taking control of anesthetic gas pollution in health care facilities. Nonetheless, occupational exposure to waste anesthetic gases still occurs (1-3). To date, several studies have investigated the risk of exposure to anesthetic agents. These studies have assessed hematopoiesis, the central nervous system, and behavioral effects, and the effects of anesthetic agents on fertility, carcinogenicity, teratogenicity, and reproduction (1,4-7).Background/aim: To assess mucociliary clearance in anesthetists who were exposed to waste anesthetic gases occupationally. Materials and methods:The first group consisted of 30 anesthetists who had been working at least 2 years. The control group of 30 subjects was selected from hospital staff with no history of occupational exposure to waste anesthetic gases. Mucociliary clearance time was assessed by measuring the saccharine nasal transit time (SNTT).Results: Thirty-six women and 24 men aged between 25 and 60 years were enrolled in the study. There were no differences between the anesthetist and control groups in terms of age, sex, height, or weight. The median SNTT for the anesthetists (10 min) was longer than that for the control group (8.3 min). The difference was significant (P = 0.025). In addition, there was a significant correlation between the SNTT and the working time (P = 0.02). Furthermore, anesthetists who had worked for 4 years or more had prolonged SNTT compared to those who had worked less than 4 years (P < 0.001). Conclusion:The present study demonstrated the impairment of mucociliary clearance in anesthetists. Increasing impairment with increasing working time was also detected.

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“…Wilkes et al demonstrated that humidification of inspired gases did not reduce the incidence of adverse airway events [13]. There was a suggestion from that study that exposure to small concentrations of isoflurane or desflurane may decrease the incidence of adverse airway incidents.…”

mentioning

confidence: 99%

Effect of breathing low concentrations of volatile anaesthetic agents on incidence of adverse airway events

Goodwin¹,

Strong²,

Sudhir³

et al. 2005

Anaesthesia

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SummaryThe effect of breathing 0.1 minimum alveolar concentrations (MAC) of desflurane or isoflurane for three minutes on the incidence of adverse airway events on a subsequent breath of 2 MAC was investigated. Twenty-five volunteers known to develop an adverse airway event to desflurane or isoflurane took part in the study. Each volunteer was exposed to isoflurane and desflurane at least 24 h apart. Volunteers were assessed for adverse airway events while breathing 2 MAC inhalational anaesthetic following breathing 100% O 2 for 3 min. This was repeated with 0.1 MAC inhalational anaesthetic in oxygen instead of 100% O 2 . Adverse airway events decreased from 88% to 40% when tests were conducted with desflurane (p = 0.002). With isoflurane, the reduction from 60% to 52% was not statistically significant (p = 0.774). Breathing low concentrations of desflurane decreases the incidence of adverse airway events on subsequent inhalation of higher concentration of desflurane.

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Adverse airway events during brief nasal inhalations of volatile anaesthetics: the effect of humidity and repeated exposure on incidence in volunteers preselected by response to desflurane*

Cited by 9 publications

References 44 publications

The Effect of Low-Flow Desflurane Anesthesia on Mucociliary Clearance

The Effect of Low-Flow Desflurane Anesthesia on Mucociliary Clearance

Assessment of nasal mucociliary clearance in anesthetists

Effect of breathing low concentrations of volatile anaesthetic agents on incidence of adverse airway events

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