Advent and Maturation of Regenerative Medicine

Abstract

The goals for regenerative medicine (RM) are focused on developing innovative tools in modern medicine. Recent progress has led to the development and clinical implementation of newer technologies, ranging from diagnostics to therapeutics for a wide variety of metabolic, degenerative, and infectious diseases.These include specific applications toward age‐ and genetic‐related human and animal dysfunctions and disorders. The focus of this review is to present, in a nutshell, the current status of adult stem cell therapy (CT) and tissue engineering (TE), including the challenges faced, progresses attained, and an optimistic view of the future. We will also provide our views on how the next 20+ years will potentially affect these RM‐driven innovations and how they are applied toward a variety of disease treatments, cures, and diagnostics.

Enhanced human bone marrow mesenchymal stem cell chondrogenic differentiation in electrospun constructs with carbon nanomaterials

“…Although promising results have been achieved, they still exhibit many shortcomings. As the most versatile and promising cell source, stem cells have been studied in tissue engineering and regenerative medicine for over a decade and hold great potential in cartilage regeneration [6][7][8][9]. However, despite their remarkable potential, one of the major challenges in successfully applying stem cells in functional cartilage tissue regeneration is the difficulty in providing the proper environmental cues to regulate their self-renewal and differentiation [10][11][12][13][14][15][16].…”