Advantages of omics technology for evaluating cadmium toxicity in zebrafish

Min, Eun Ki; Lee, Ahn Na; Lee, Ji-Young; Shim, Ilseob; Kim, Pilje; Kim, Tae‐Young; Kim, Ki-Tae; Lee, Sangkyu

doi:10.1007/s43188-020-00082-x

Cited by 8 publications

(9 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Juvenile parrotfish, Oplegnathus fasciatus , were exposed to Cd mixed with a fish diet, and the result displayed that tissue Cd concentrations increased with the Cd content of the diets, and Cd accumulated the most in the liver, followed by the gill and then muscle [ 24 ]. Because zebrafish ( Danio rerio ) share 87% genetic homology with humans, their embryos, larvae, and adult fish are employed as standard models for many toxicity tests, and a summary of the toxic effects of cadmium in zebrafish is shown as Table 2 [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Toxic Effects of Cadmium on Fish

Liu

Chen

et al. 2022

Toxics

View full text Add to dashboard Cite

Large amounts of enriched cadmium (Cd) in the environment seriously threatens the healthy and sustainable development of the aquaculture industry and greatly restricts the development of the food processing industry. Studying the distribution and toxic effects of Cd in fish, as well as the possible toxic effects of Cd on the human body, is very significant. A large number of studies have shown that the accumulation and distribution of Cd in fish are biologically specific, cause tissue differences, and seriously damage the integrity of tissue structure and function, the antioxidant defense system, the reproductive regulation system, and the immune system. The physiological, biochemical, enzyme, molecular, and gene expression levels change with different concentrations and times of Cd exposure, and these changes are closely related to the target sites of Cd action and tissues in fish. Therefore, the toxic effects of Cd on fish occur with multiple tissues, systems, and levels.

show abstract

Section: Introductionmentioning

confidence: 99%

Toxic Effects of Cadmium on Fish

Liu

Chen

et al. 2022

Toxics

View full text Add to dashboard Cite

show abstract

“…Toxicological effects of Cd on zebrafish at different developmental stages. Zebrafish at different developmental stages were used as model organisms to detect the toxic effects of Cd, a common metal pollutant, even in the same organ, and the toxic effects were different at different developmental stages [30,31].…”

Section: Figurementioning

confidence: 99%

Research Progress of Zebrafish Model in Aquatic Ecotoxicology

Liu

Chen

et al. 2023

Water

View full text Add to dashboard Cite

In recent years, with the aggravation of environmental pollution, the study of aquatic ecotoxicology has become a hot topic. Some aquatic organisms, such as large fleas, toads, and zebrafish, have been developed and applied as model organisms. They have been increasingly used to study the bioaccumulation and toxicity of environmental pollutants due to the advantages of their small size, easy reproduction, short life cycle, low maintenance cost, and ability to combine genetic, cellular, and whole organism endpoints. This review summarizes the methods of zebrafish, as a model in aquatic ecotoxicology, using its developmental toxicity, biomarkers, genomics, and phenotype analysis to evaluate the toxicity of environmental pollutants, providing a reference value for researchers to select model animals for aquatic ecotoxicology research.

show abstract

“…Toxicogenomics refers to genome-wide studies (omics) applied to toxicology [1]. There are special omics terms in areas of toxicological research based on a single omic technology, such as toxicogenomics, toxicoproteomics, and toxicometabolomics [5,7,17], and bioinformatics tools used to examine the databases they generate (Fig. 1).…”

Section: Toxicogenomics: What Is In a Name?mentioning

confidence: 99%

“…Zebrafish (Danio rerio) embryos and larva are utilized as standard models for many toxicity tests because they share 71% genetic homology with humans. Toxicogenomic was used to evaluate cadmium toxicity in zebrafish [17]. Cadmium is a toxic heavy metal posing several environmental concerns.…”

Section: Illustrative Case #mentioning

confidence: 99%

See 1 more Smart Citation

Perspectives on the Use of Toxicogenomics to Assess Environmental Risk

Portugal¹,

Mansilla²,

Piña³

2022

Front. Biosci. (Landmark Ed)

View full text Add to dashboard Cite

Environmental toxicogenomics aims to collect, analyze and interpret data on changes in gene expression and protein activity resulting from exposure to toxic substances using high-performance omics technologies. Molecular profiling methods such as genomics, transcriptomics, proteomics, metabolomics, and bioinformatics techniques, permit the simultaneous analysis of a multitude of gene variants in an organism exposed to toxic agents to search for genes prone to damage, detect patterns and mechanisms of toxicity, and identify specific gene expression profiles that can provide biomarkers of exposure and risk. Compared to previous approaches to measuring molecular changes caused by toxicants, toxicogenomic technologies can improve environmental risk assessment while reducing animal studies. We discuss the prospects and limitations of converting omic datasets into valuable information, focusing on assessing the risks of mixed toxic substances to the environment and human health.

show abstract

Advantages of omics technology for evaluating cadmium toxicity in zebrafish

Cited by 8 publications

References 96 publications

Toxic Effects of Cadmium on Fish

Toxic Effects of Cadmium on Fish

Research Progress of Zebrafish Model in Aquatic Ecotoxicology

Perspectives on the Use of Toxicogenomics to Assess Environmental Risk

Contact Info

Product

Resources

About