Advantages of nanocarriers for basic research in the field of traumatic brain injury

Song, Xingshuang; Zhang, Yizhi; Tang, Ziyan; Du, Lina

doi:10.4103/1673-5374.379041

Cited by 2 publications

(1 citation statement)

References 126 publications

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“…Several methods have been described for selective drug loading and delivery: bacteria, viruses, cells, polymer-based or synthetic lipid carrier systems as well as extracellular vesicles [ 2 ]. Mesenchymal stromal cells (MSC) represent a family of undifferentiated multipotent adult cells presenting wide self-renewal features and the capacity to differentiate into an assortment of mesenchymal lineage cells [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Stem cell technology for antitumor drug loading and delivery in oncology

PETRELLA,

CASSINA,

LIBRETTI

et al. 2024

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The main aim of antineoplastic treatment is to maximize patient benefit by augmenting the drug accumulation within affected organs and tissues, thus incrementing drug effects and, at the same time, reducing the damage of noninvolved tissues to cytotoxic agents. Mesenchymal stromal cells (MSC) represent a group of undifferentiated multipotent cells presenting wide self-renewal features and the capacity to differentiate into an assortment of mesenchymal family cells. During the last year, they have been proposed as natural carriers for the selective release of antitumor drugs to malignant cells, thus optimizing cytotoxic action on cancer cells, while significantly reducing adverse side effects on healthy cells. MSC chemotherapeutic drug loading and delivery is an encouraging new area of cell therapy for several tumors, especially for those with unsatisfactory prognosis and limited treatment options available. Although some experimental models have been successfully developed, phase I clinical studies are needed to confirm this potential application of cell therapy, in particular in the case of primary and secondary lung cancers.

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Section: Introductionmentioning

confidence: 99%

Stem cell technology for antitumor drug loading and delivery in oncology

PETRELLA,

CASSINA,

LIBRETTI

et al. 2024

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The establishment and application of a dual Nano-PCR detection method for feline calicivirus and feline herpesvirus type I

Yan,

Shang,

Zhang

et al. 2023

Front. Microbiol.

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Feline calicivirus (FCV) and Feline herpesvirus type I (FHV-I) are the main pathogens causing upper respiratory tract infections in cats, and some wild animals. These two viruses always coinfection and cause serious harm to pet industry and wild animals protection. Established a rapid and accurate differential diagnosis method is crucial for prevention and control of disease, however, the current main detection method for these two viruses, either is low sensitivity (immunochromatographic strip), or is time-consuming and cannot differential diagnosis (conventional single PCR). Nanoparticle-assisted polymerase chain reaction (Nano-PCR) is a recently developed technique for rapid detection method of virus and bacteria. In this study, we described a dual Nano-PCR assay through combining the nanotechnology and PCR technology, which for the clinical simultaneous detection of FCV and FHV-I and differential diagnosis of upper respiratory tract infections in cats or other animals. Under optimized conditions, the optimal annealing temperature for dual Nano-PCR was 51.5°C, and specificity test results showed it had no cross reactivity to related virus, such as feline panleukopenia virus (FPV), feline Infectious peritonitis virus (FIPV) and rabies virus (RABV). Furthermore, the detection limit of dual Nano-PCR for FCV and FHV-I both were 1 × 10−8 ng/μL, convert to number of copies of virus DNA was 6.22 × 103copies/μL (FCV) and 2.81 × 103copies/μL (FHV-I), respectively. The dual Nano-PCR detected result of 52 cat clinical samples, including ocular, nasal and faecal swabs, and (3 FCV-positive samples), was consistent with ordinary PCR and the clinical detection results. The dual Nano-PCR method established in this study with strong specificity and high sensitivity can be used for virus nucleic acid (FCV and FHV-I) detection of clinical samples of feline upper respiratory tract infections feline calicivirus and feline herpesvirus while providing support for the early diagnosis of cats that infected by FCV and FHV-I.

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Advantages of nanocarriers for basic research in the field of traumatic brain injury

Cited by 2 publications

References 126 publications

Stem cell technology for antitumor drug loading and delivery in oncology

Stem cell technology for antitumor drug loading and delivery in oncology

The establishment and application of a dual Nano-PCR detection method for feline calicivirus and feline herpesvirus type I

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