Advancing the Science and Technology of Electrospinning and Functional Nanofibers

Persano, Luana; Camposeo, Andrea; Pisignano, Dario

doi:10.1002/mame.201700237

Cited by 11 publications

(13 citation statements)

References 10 publications

(10 reference statements)

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“…Chitosan from crab shells, which is highly viscous (Sigma) in the form of crystals, is characterized by structural viscosity 1267 MPaxs and sulfated ash 0.2%. Poly(ethylene oxide) (PEO), M w 100,000 g mol −1 , powder (Alpha Aesar, Kandel, Germany) with a melting point of 65 • C and a density of 1.4539 g/cm 3 was used. PEO shows good biocompatibility and low toxicity and it is soluble in toluene, tetrahydrofuran, hot water, dimethylformamide, and chloroform, which are solvents generally used in the electrospinning process of biomaterials [32].…”

Section: Methodsmentioning

confidence: 99%

“…PEO shows good biocompatibility and low toxicity and it is soluble in toluene, tetrahydrofuran, hot water, dimethylformamide, and chloroform, which are solvents generally used in the electrospinning process of biomaterials [32]. Glacial acetic acid (Alfa Aesar, Kandel, Germany) with density of 1.05 g/cm 3 and distilled water were used as solvents.…”

Section: Methodsmentioning

confidence: 99%

“…The novelty of this research includes the production of nanofibers from low-molecular weight collagen and keratin hydrolysates with a high content of proteins (13.6% w/v, 25% w/v, and 22% w/v for collagen hydrolysate, rabbit collagen glue, and keratin hydrolysate, respectively) by electrospinning. The objectives of this study were (1) to extract and characterize the collagen hydrolysate (HC10), collagen glue (RCG), and keratin hydrolysate (KH) from bovine tanned leather by-products, pickled rabbit skin, and sheepskin wool, respectively; (2) to characterize the protein-based nanofibers obtained by electrospinning for potential biomedical field application; and (3) to demonstrate that the structure of protein-based nanofibers still preserves the secondary collagen structure without being totally affected by the extraction and electrospinning processing conditions. The nanofibers' surface and mechanical properties have been confirmed using scanning electron microscopy coupled with the energy-dispersive spectroscopy (SEM-EDS) technique, attenuated total reflectance Fourier transform infrared spectroscopy (ATR FT-IR), differential scanning calorimetry (DSC), and indentation tests (Nanoindenter XP).…”

Section: Introductionmentioning

confidence: 99%

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New Nanofibers Based on Protein By-Products with Bioactive Potential for Tissue Engineering

et al. 2020

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Concentrated collagen hydrolysate (HC10CC), rabbit collagen glue (RCG), and keratin hydrolysate (KH) were investigated in terms of their extraction from mammalian by-products and processing by electrospinning. The electrospun nanofibers were characterized by scanning electron microscopy coupled with the energy dispersive X-ray spectroscopy (SEM/EDS), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC), and indentation tests. The cytotoxicity of the electrospun nanofibers was conducted on L929 fibroblast cells using MTT and LDH assays and cell morphology observations. The electrospun RCG and KH nanofibers morphology showed an average size of nanofibers ranging between 44 and 410 nm, while the electrospun HC10CC nanofibers exhibited higher sizes. The ATR-FTIR spectra performed both on extracted proteins and electrospun nanofibers showed that the triple helix structure of collagen is partially preserved. The results were in agreement with the circular dichroism analysis for protein extracts. Furthermore, the viscoelastic properties of electrospun KH nanofibers were superior to those of electrospun RCG nanofibers. Based on both in vitro quantitative and qualitative analysis, the electrospun nanofibers were not cytotoxic, inducing a healthy cellular response. The results of new electrospun protein-based nanofibers may be useful for further research on bioactive properties of these nanofibers for tissue engineering.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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New Nanofibers Based on Protein By-Products with Bioactive Potential for Tissue Engineering

et al. 2020

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“…It is continued by pioneers to the present time . Now, at this time, many procedures associated with various materials are described in literature for specific applications …”

Section: Introductionmentioning

confidence: 99%

Extraction of nanofibers from polymer blends: A brief review

Rabiei

Kish

2018

Polymers for Advanced Techs

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This review is about the naturally formed and intentionally produced nanofibrils or nanofibers (NFs) that have been extracted and utilized or expected to be used for special applications. The diameter of NFs ranges between a few to a few hundred nanometers. Methods to arrange synthetic NFs assembly in yarns or pads forms have been examined. High throughput productions, versatility of various thermoplastics, and less environmental pollution are the advantages of the methods of extraction, which seems to make it as an economical process. It can also be used for the polymers that are difficult to be converted to NFs by electrospinning. The process is challenging and scientifically fascinating to attract the investigators. There are many more polymers to be considered, and there are many more envisioned applications that have to be practiced in the future. A theoretical base is needed for the evaluation of the effects of polymer flow parameters on the extracted NFs properties.

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“…Chemical sensors based on functional nanofibers made by electrospinning (e.g. in wearable sensors) are also a significant area of research [27].…”

Section: Introductionmentioning

confidence: 99%

Customization of Electrospinning for Tissue Engineering

et al. 2018

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This paper deals with two electrospinning technologies: the melt electrospinning with a customized jet head, adapted from the fused deposition modeling (FDM) 3D printer, in comparison with the standard solution electrospinning, aiming at fabrication of tissue engineering scaffolds. The resulting fibers are compared. The influence of the collector properties on those of the fabricated scaffold is investigated. The resulting electrospun fibers exhibit different characteristics such as morphology and thickness, depending on the technology. The micro-fibers are produced by the melt electrospinning with an inbuilt 3D printer jet head, whereas the solution electrospinning has produced nano- and micro-fibers. The scaffolds fabricated on the rotating drum collector exhibit a more ordered structure as well as thinner fibers than those produced on the stationary plate collector. Further investigations should aim at fabrication of porous hollow fibers and tissue engineering scaffolds with controlled porosity and properties.

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Advancing the Science and Technology of Electrospinning and Functional Nanofibers

Cited by 11 publications

References 10 publications

New Nanofibers Based on Protein By-Products with Bioactive Potential for Tissue Engineering

New Nanofibers Based on Protein By-Products with Bioactive Potential for Tissue Engineering

Extraction of nanofibers from polymer blends: A brief review

Customization of Electrospinning for Tissue Engineering

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