Advancing the frontiers of silk fibroin protein-based materials for futuristic electronics and clinical wound-healing (Invited review)

Koh, Leng-Duei; Yeo, Jingjie; Lee, Yeong Yuh; Qunya, Ong; Han, Ming‐Yong; Tee, Benjamin C. K.

doi:10.1016/j.msec.2018.01.007

Cited by 113 publications

(90 citation statements)

References 164 publications

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“…9,10 A wide variety of structures and morphologies can be obtained from silk broin, 11 its functional characteristics and processability supporting the selection of silk broin 12 for a wide range of applications in the areas of biomedicine, 13 opticals, photonics and electronics. 14,15 Piezoresistive sensors based on natural polymers are useful for force and deformation measurements, and have a high potential in the scope of Industry 4.0 and Internet of Things paradigms, which increasingly demand a large variety of environmentally friendlier sensors. 16,17 There are different types of piezoresistive sensors; however, taking into account their exibility, easy processability and integrability, the most outstanding are piezoresistive polymer based composites.…”

Section: Introductionmentioning

confidence: 99%

Optimized silk fibroin piezoresistive nanocomposites for pressure sensing applications based on natural polymers

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Optimized silk fibroin piezoresistive nanocomposites for pressure sensing applications based on natural polymers

et al. 2019

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“…These systems would fit into the category of highly biocompatible physical engines capable of sensing and controlling flux. Koh and colleagues specifically reviewed this need as ‘a ‘green’ approach for manufacturing next-generation wearable, implantable, self-resorbable electronics and energy-devices’ ( 103 ). This approach requires natural materials or adapted natural materials that, in this context, can outperform synthetic materials.…”

Section: Introductionmentioning

confidence: 99%

A Review of the Emerging Role of Silk for the Treatment of the Eye

2018

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Silk is a remarkable biopolymer with a long history of medical use. Silk fabrications have a robust track record for load-bearing applications, including surgical threads and meshes, which are clinically approved for use in humans. The progression of top-down and bottom-up engineering approaches using silk as the basis of a drug delivery or cell-loaded matrix helped to re-ignite interest in this ancient material. This review comprehensively summarises the current applications of silk for tissue engineering and drug delivery, with specific reference to the eye. Additionally, the review also covers emerging trends for the use of silk as a biologically active biopolymer for the treatment of eye disorders. The review concludes with future capabilities of silk to contribute to advanced, electronically-enhanced ocular drug delivery concepts.

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“…Silk fibroin proteins obtained from Bombyx mori cocoons display outstanding mechanical properties that stem from a delicate hierarchical structure spanning different length scales . As shown in earlier work, the biocompatibility and biodegradability of silk fibroin proteins provide utility for the manufacturing of materials with applications in biomedicine, flexible electronics, or water purification . Furthermore, adding plasticizers, such as glycerol or CaCl 2 , increases the match of mechanical properties of silk fibroin with biological tissues and enables the development of silk‐based, soft, conformable biomaterials.…”

Section: Mechanical Properties Of Silk Fibroin–biobased Carbon Gaugesmentioning

confidence: 78%

Conductive Silk‐Based Composites Using Biobased Carbon Materials

et al. 2019

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There is great interest in developing conductive biomaterials for the manufacturing of sensors or flexible electronics with applications in healthcare, tracking human motion, or in situ strain measurements. These biomaterials aim to overcome the mismatch in mechanical properties at the interface between typical rigid semiconductor sensors and soft, often uneven biological surfaces or tissues for in vivo and ex vivo applications. Here, the use of biobased carbons to fabricate conductive, highly stretchable, flexible, and biocompatible silk‐based composite biomaterials is demonstrated. Biobased carbons are synthesized via hydrothermal processing, an aqueous thermochemical method that converts biomass into a carbonaceous material that can be applied upon activation as conductive filler in composite biomaterials. Experimental synthesis and full‐atomistic molecular dynamics modeling are combined to synthesize and characterize these conductive composite biomaterials, made entirely from renewable sources and with promising applications in fields like biomedicine, energy, and electronics.

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Advancing the frontiers of silk fibroin protein-based materials for futuristic electronics and clinical wound-healing (Invited review)

Cited by 113 publications

References 164 publications

Optimized silk fibroin piezoresistive nanocomposites for pressure sensing applications based on natural polymers

Optimized silk fibroin piezoresistive nanocomposites for pressure sensing applications based on natural polymers

A Review of the Emerging Role of Silk for the Treatment of the Eye

Conductive Silk‐Based Composites Using Biobased Carbon Materials

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