2023
DOI: 10.1016/j.phrs.2022.106627
|View full text |Cite
|
Sign up to set email alerts
|

Advancing targeted protein degradation for metabolic diseases therapy

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
11
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 24 publications
(15 citation statements)
references
References 210 publications
0
11
0
Order By: Relevance
“…1,3,6 The advantages of PROTACs have generated enthusiasm among researchers in both chemical biology and drug discovery fields, providing novel treatment options for various diseases including cancers, 7 neurodegenerative disorders, 8 and metabolic syndromes. 9 However, despite the revolutionary role of PROTACs in the drug discovery paradigm by enabling precise and effective degradation of the POI, there are still some limitations that hinder the clinical application of PROTACs. Firstly, due to their unique molecular composition and structural characteristics, PROTACs often exhibit suboptimal water solubility and tissue permeability.…”
Section: Ruiqi Zhaomentioning
confidence: 99%
“…1,3,6 The advantages of PROTACs have generated enthusiasm among researchers in both chemical biology and drug discovery fields, providing novel treatment options for various diseases including cancers, 7 neurodegenerative disorders, 8 and metabolic syndromes. 9 However, despite the revolutionary role of PROTACs in the drug discovery paradigm by enabling precise and effective degradation of the POI, there are still some limitations that hinder the clinical application of PROTACs. Firstly, due to their unique molecular composition and structural characteristics, PROTACs often exhibit suboptimal water solubility and tissue permeability.…”
Section: Ruiqi Zhaomentioning
confidence: 99%
“…Lysosomes are membrane-bound organelles providing approximately 50 different types of acid hydrolases, which play important roles in the degradation of various biomacromolecules such as carbohydrates, nucleic acids, proteins, fats, and cellular components. [1][2][3] Lysosomes are crucial for several cellular processes, including cholesterol in vivo balance, autophagy, plasma membrane repair, bone and tissue remodeling, pathogen defense, cell signaling and death. [4][5][6] Due to the exclusive role of lysosomal transport during tumor invasion and metastasis, the effective monitoring of intracellular lysosome has emerged as a fascinating target for cancer diagnosis and treatment.…”
Section: Introductionmentioning
confidence: 99%
“… 4 As a result, the most recent strategies aimed to discover and seek out certain biological markers crucial for cancerous cells such as aberrant, modified or overstated proteins. 5 In recent times, tubulin polymerization has been recognized as a significant molecular target for the search and development of anticancer drugs. 6 The polymerization of tubulin is necessary to form microtubules that have a crucial role in cellular functions, including the maintenance of cellular structure, intracellular transportation as well as mitotic spindle formation for cell division.…”
Section: Introductionmentioning
confidence: 99%