Advancing targeted protein degradation for metabolic diseases therapy

Nano-PROTACs: state of the art and perspectives

“…1,3,6 The advantages of PROTACs have generated enthusiasm among researchers in both chemical biology and drug discovery fields, providing novel treatment options for various diseases including cancers, 7 neurodegenerative disorders, 8 and metabolic syndromes. 9 However, despite the revolutionary role of PROTACs in the drug discovery paradigm by enabling precise and effective degradation of the POI, there are still some limitations that hinder the clinical application of PROTACs. Firstly, due to their unique molecular composition and structural characteristics, PROTACs often exhibit suboptimal water solubility and tissue permeability.…”

Lysosome-targeting solid state NIR emissive donor–acceptor molecules: a study on photophysical modulation through architectural distinction

“…Lysosomes are membrane-bound organelles providing approximately 50 different types of acid hydrolases, which play important roles in the degradation of various biomacromolecules such as carbohydrates, nucleic acids, proteins, fats, and cellular components. [1][2][3] Lysosomes are crucial for several cellular processes, including cholesterol in vivo balance, autophagy, plasma membrane repair, bone and tissue remodeling, pathogen defense, cell signaling and death. [4][5][6] Due to the exclusive role of lysosomal transport during tumor invasion and metastasis, the effective monitoring of intracellular lysosome has emerged as a fascinating target for cancer diagnosis and treatment.…”

Design, synthesis and cytotoxic activity of molecular hybrids based on quinolin-8-yloxy and cinnamide hybrids and their apoptosis inducing property

“… 4 As a result, the most recent strategies aimed to discover and seek out certain biological markers crucial for cancerous cells such as aberrant, modified or overstated proteins. 5 In recent times, tubulin polymerization has been recognized as a significant molecular target for the search and development of anticancer drugs. 6 The polymerization of tubulin is necessary to form microtubules that have a crucial role in cellular functions, including the maintenance of cellular structure, intracellular transportation as well as mitotic spindle formation for cell division.…”