Advancing Prostate Cancer Staging: A Single-Step Approach With Bi-parametric and Whole-Body Diffusion MRI in an African Cohort

Asafu Adjaye Frimpong, George; Aboagye, Evans; Asante, Emmanuel; Appiah, Kwaku Addai  A; Owusu-Afriyie, Osei; Asare, Adwoa O; Atuobi, Dorcas; Akpaloo, Bernard D; Antwi, Bright

doi:10.7759/cureus.59470

Cureus

2024

DOI: 10.7759/cureus.59470

|View full text |Cite

Advancing Prostate Cancer Staging: A Single-Step Approach With Bi-parametric and Whole-Body Diffusion MRI in an African Cohort

George Asafu Adjaye Frimpong,

Evans Aboagye,

Emmanuel Asante

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite1

Independent0

Authors

Journals

Cited by 1 publication

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Anatomic Locations and Metastatic Risk in Prostate Cancer in African Men: Insights From an African Cohort

Asafu Adjaye Frimpong,

Aboagye,

Owusu-Afriyie

et al. 2024

Cureus

Self Cite

View full text Add to dashboard Cite

Background: There is significant variability in the pathogenetic characteristics of prostate cancer (PCa) across different anatomical zones. This study aims to understand the metastatic risk associated with these zonal predispositions among African men. Methods: This hospital-based retrospective observational study included 120 biopsy-confirmed PCa patients examined between 2019 and 2023. Data on cancer history, sociodemographic, and clinical characteristics were collected from medical records. A logistic regression model was used to identify predictors of metastasis. Results: The majority of PCa lesions were found in the left (60.0%) and right peripheral zones (55.8%), followed by the left (42.5%) and right transitional zones (41.7%). Lesions in the anterior fibromuscular stroma (crude odds ratio (cOR): 3.27, 95% confidence interval (CI): 1.13-9.47; p = 0.029), central gland (cOR: 5.38, 95% CI: 1.40-20.60; p = 0.014), and diffuse infiltration involving whole gland (cOR: 6.78, 95% CI: 1.17-30.07; p = 0.032) were associated with significantly increased odds of metastasis. Lesions in the anterior fibromuscular stroma were a marginally independent predictor of metastasis (adjusted odds ratio (aOR): 28.14, 95% CI: 0.96-822.46; p = 0.053). Conclusions: This study underscores the variability in metastatic risk of PCa lesions across different anatomical zones in African men. Lesions in the anterior fibromuscular stroma, central gland, and diffuse infiltration involving the whole gland have higher odds of metastasis. These findings highlight the need for targeted diagnostic and therapeutic strategies based on lesion localization to improve PCa management in this population.

show abstract

Anatomic Locations and Metastatic Risk in Prostate Cancer in African Men: Insights From an African Cohort

Asafu Adjaye Frimpong,

Aboagye,

Owusu-Afriyie

et al. 2024

Cureus

Self Cite

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Advancing Prostate Cancer Staging: A Single-Step Approach With Bi-parametric and Whole-Body Diffusion MRI in an African Cohort

Cited by 1 publication

References 28 publications

Anatomic Locations and Metastatic Risk in Prostate Cancer in African Men: Insights From an African Cohort

Anatomic Locations and Metastatic Risk in Prostate Cancer in African Men: Insights From an African Cohort

Contact Info

Product

Resources

About