Advancing Ki67 hotspot detection in breast cancer: a comparative analysis of automated digital image analysis algorithms
Mieke C Zwager,
Shibo Yu,
Henk J Buikema
et al.
Abstract:AimManual detection and scoring of Ki67 hotspots is difficult and prone to variability, limiting its clinical utility. Automated hotspot detection and scoring by digital image analysis (DIA) could improve the assessment of the Ki67 hotspot proliferation index (PI). This study compared the clinical performance of Ki67 hotspot detection and scoring DIA algorithms based on virtual dual staining (VDS) and deep learning (DL) with manual Ki67 hotspot PI assessment.MethodsTissue sections of 135 consecutive invasive b… Show more
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