Advancing human disease research with fish evolutionary mutant models

Beck, Emily A.; Healey, Hope M; Small, Clayton M.; Currey, Mark; Desvignes, Thomas; Cresko, William A.; Postlethwait, John H.

doi:10.1016/j.tig.2021.07.002

Cited by 28 publications

(23 citation statements)

References 196 publications

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“…Generally, most analyses did not support the hypothesis that icefish bones have altered bone microstructure compared to closely related notothenioids. As such, these data do not support the hypothesis that icefishes might serve as an evolutionary model for osteoporosis (Albertson et al, 2009 ; Beck et al, 2021 ; Kawalilak et al, 2014 ).…”

Section: Discussionmentioning

confidence: 66%

Bone microstructure and bone mineral density are not systemically different in Antarctic icefishes and related Antarctic notothenioids

et al. 2021

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Section: Discussionmentioning

confidence: 66%

Bone microstructure and bone mineral density are not systemically different in Antarctic icefishes and related Antarctic notothenioids

et al. 2021

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“…Small teleost fish, like zebrafish or medaka, has been recently considered as models to study human neurological disorders including ASD [ 86 ], peripheral neuropathy [ 87 ], and behavioral neuroscience [ 88 ] since they possess several key advantages [ 89 ]. First, they consist of a phylogenetically diverse group with species that have evolved phenotypes naturally mimicking human diseases, called “evolutionary mutant models” [ 90 , 91 , 92 ]. Cross-species comparisons allow for the identification of the best models to study a specific physiological pathway [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Fish as Model Systems to Study Epigenetic Drivers in Human Self-Domestication and Neurodevelopmental Cognitive Disorders

Anastasiadi

Piferrer

Wellenreuther

et al. 2022

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Modern humans exhibit phenotypic traits and molecular events shared with other domesticates that are thought to be by-products of selection for reduced aggression. This is the human self-domestication hypothesis. As one of the first types of responses to a novel environment, epigenetic changes may have also facilitated early self-domestication in humans. Here, we argue that fish species, which have been recently domesticated, can provide model systems to study epigenetic drivers in human self-domestication. To test this, we used in silico approaches to compare genes with epigenetic changes in early domesticates of European sea bass with genes exhibiting methylation changes in anatomically modern humans (comparison 1), and neurodevelopmental cognitive disorders considered to exhibit abnormal self-domestication traits, i.e., schizophrenia, Williams syndrome, and autism spectrum disorders (comparison 2). Overlapping genes in comparison 1 were involved in processes like limb morphogenesis and phenotypes like abnormal jaw morphology and hypopigmentation. Overlapping genes in comparison 2 affected paralogue genes involved in processes such as neural crest differentiation and ectoderm differentiation. These findings pave the way for future studies using fish species as models to investigate epigenetic changes as drivers of human-self domestication and as triggers of cognitive disorders.

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“…Small teleost fish, like zebrafish or medaka, have been recently considered as models to study human neurological disorders including ASD [85], peripheral neuropathy [86] and for behavioral neuroscience [87] since they possess several key advantages [88]. First, they consist of a phylogenetically diverse group with species that have evolved phenotypes naturally mimicking human diseases, called "evolutionary mutant models" [89][90][91]. Cross-species comparisons allow to identify the best models to study a specific physiological pathway [39].…”

Section: Discussionmentioning

confidence: 99%

Fish as model systems to study epigenetic drivers in human self-domestication and neurodevelopmental cognitive disorders

Anastasiadi

Piferrer

Wellenreuther

et al. 2022

Preprint

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Modern humans exhibit phenotypic traits that are shared across independent domestication events, suggesting the human self-domestication hypothesis. Epigenetic changes may facilitate early self-domestication in humans, since they can be the first layer of response to a novel environment. Here, we argue that fish provide model systems to study epigenetic drivers in human self-domestication. To do this, we compare genes that carry epigenetic changes in early domesticates of European sea bass with 1) anatomically modern humans and 2) neurodevelopmental cognitive disorders with abnormal self-domestication traits, i.e., schizophrenia, Williams syndrome and autism spectrum disorders. We found that genes with epigenetic changes in fish and in modern vs ancient humans were shared and were involved in processes like limb morphogenesis and phenotypes like abnormal snout morphology and hypopigmentation. Moreover, early domestication in fish and neurodevelopmental cognitive impairment in humans affected paralogue genes involved in processes such as neural crest differentiation and ectoderm differentiation. We conclude that parallel epigenetic changes may occur at the initial steps of domestication in absence of deliberate selection in phylogenetically distant vertebrates. These findings pave the way for future studies using fish as models to investigate epigenetic changes as drivers of human-self domestication and as triggers of cognitive disorders.

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Advancing human disease research with fish evolutionary mutant models

Cited by 28 publications

References 196 publications

Bone microstructure and bone mineral density are not systemically different in Antarctic icefishes and related Antarctic notothenioids

Bone microstructure and bone mineral density are not systemically different in Antarctic icefishes and related Antarctic notothenioids

Fish as Model Systems to Study Epigenetic Drivers in Human Self-Domestication and Neurodevelopmental Cognitive Disorders

Fish as model systems to study epigenetic drivers in human self-domestication and neurodevelopmental cognitive disorders

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